The DOI matches its Crossref record.
Physiological Concentrations of Growth Hormone Exert Insulin-Like and Insulin Antagonistic Effects on Both Hepatic and Extrahepatic Tissues in Man*
Abstract
To determine whether increments in circulating GH concentrations within the physiological range would exert insulin-like as well as insulin-antagonistic actions in man and, if so, whether both actions would occur in hepatic and extrahepatic tissues, normal volunteers (n = 6) were infused with human GH (hGH; 100 ng/kg . min) for 6 h along with somatostatin (100 micrograms/h) to suppress insulin, glucagon, and hGH secretion and also with sufficient insulin (100 microU/kg . min) to maintain a constant plasma insulin level. During the final 2 h, glucose (2 mg/kg . min) was infused. In control studies, saline was infused instead of hGH. Infusion of hGH increased plasma hGH to 35 ng/ml. Plasma glucose decreased to 60 +/- 2 mg/dl compared to 67 +/- 1 mg/dl observed in control studies (P less than 0.05); this greater hypoglycemia was due to both greater suppression of hepatic glucose production (P less than 0.05) and greater augmentation of glucose clearance (P less than 0.05). These insulin-like effects of hGH were no longer evident after 2 h. Subsequently, when glucose was infused, plasma glucose increased to 133 +/- 4 mg/dl compared to the 104 +/- 6 mg/dl observed in control studies (P less than 0.01). This greater hyperglycemia was due to both impaired suppression of hepatic glucose production (P less than 0.001) and decreased glucose clearance (P less than 0.01). These results indicate that physiological increments in plasma hGH cause both insulin-like and insulin-antagonistic effects in man and that these actions occur in hepatic as well as extrahepatic tissues. The insulin-like actions of hGH are transient.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, the hyperglycemic actions of both growth hormone (2) and cortisol (3) are too slow.”
In the citing paper
“earlier studies indicated that in the basal state, GH administration induces an early insulin-like effect on glucose metabolism [6,7]”
From Effects of growth hormone on insulin sensitivity and forearm metabolism in normal man (1989) · cites this paper as [7]
Citations
Cited by
Sorted by citations
The Somatomedin Hypothesis: 2001
Roith, D. L., Bondy, C. A., Yakar, S., Liu, J., & Butler, A. A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0419 · Cited by 1,272
“Long-term administration of GH inhibits glucose uptake by inducing a state of insulin resistance (180).”
BackgroundAssessment of Insulin Sensitivityin Vivo*
Bergman, R. N., Finegood, D. T., & Ader, M. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-1-45 · Cited by 1,072
Effect of Growth Hormone on Carbohydrate and Lipid Metabolism
Davidson, M. B. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-115 · Cited by 567
Fasting glucose is a risk factor for breast cancer: a prospective study.
Muti, P. C., Quattrin, T., Grant, B. J. B., Krogh, V., Micheli, A., Schünemann, H. J., Ram, M., Freudenheim, J. L., Sieri, S., Trevisan, M., et al. (2002) · PubMed · Cited by 358
The Effect of Growth Hormone on Glucose Metabolism and Insulin Secretion in Man*
BRATUSCH-MARRAIN, P. R., SMITH, D., & DEFRONZO, R. A. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-5-973 · Cited by 321
Metadata
- Authors
- MACGORMAN, L. R., RIZZA, R. A., & GERICH, J. E.
- Affiliations
- Mayo Clinic (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1981-09
- Volume
- 53
- Issue
- 3
- Pages
- 556-559
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1995945960
- Cited by
- 175
- References
- 0
- Citations by year
- 2025: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- growth hormone, insulin-like activity, insulin antagonism, hepatic glucose production, glucose clearance, hypoglycemia, hyperglycemia, somatostatin, insulin infusion, glucose infusion, extrahepatic tissues
- MeSH terms
- Adult, Blood Glucose, Female, Glucagon, Glucose, Humans, Insulin, Kinetics, Liver, Male, Somatostatin, Growth Hormone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
