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Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*
Abstract
We have assessed the effect of fasting for 10 days on plasma concentrations of immunoreactive somatomedin C and urinary urea excretion in seven obese male volunteers. From a mean prefast value of 0.83 U/ml, plasma somatomedin C fell to 0.21 U/ml after 10 days of fasting. A prompt increase was observed with refeeding. The change in somatomedin C during fasting showed a highly significant correlation with the change in urinary urea nitrogen excretion (r = 0.74; P less than 0.001). It also was shown that inhibitors which interfere with quantitation in somatomedin bioassays are not observed in the RIA for somatomedin C. The results of this study suggest that measurement of plasma somatomedin C provides a sensitive indicator of nitrogen loss and may be useful in monitoring the changes in protein metabolism that occur during alterations in nutritional status.
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Citations
Cited by
Ho, K. Y., Veldhuis, J. D., Johnson, M. L., Furlanetto, R., Evans, W. S., Alberti, K. G., & Thorner, M. O. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113450 · Cited by 503
Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00417.x · Cited by 393
Nam, S., Lee, E., Kim, K., Cha, B., Song, Y., Lim, S., Lee, H., & Huh, K. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800412 · Cited by 388
Plank, L. D., Gane, E. J., Peng, S., Muthu, C., Mathur, S., Gillanders, L., McIlroy, K., Donaghy, A. J., & McCall, J. L. (2008) · Hepatology · doi:10.1002/hep.22367 · Cited by 325
Binnerts, A., Swart, G. R., Wilson, J. H. P., Hoogerbrugge, N., Pois, H. A. P., Birkenhager, J. C., & Lamberts, S. W. J. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02287.x · Cited by 315
Metadata
- Authors
- CLEMMONS, D. R., KLIBANSKI, A., UNDERWOOD, L. E., McARTHUR, J. W., RIDGWAY, E. C., BEITINS, I. Z., & VAN WYK, J. J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1981-12
- Volume
- 53
- Issue
- 6
- Pages
- 1247-1250
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2134581787
- Cited by
- 364
- References
- 0
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*. https://app.cochat.ai/papers/10.1210/jcem-53-6-1247
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- CLEMMONS, D. R., KLIBANSKI, A., UNDERWOOD, L. E., McARTHUR, J. W., RIDGWAY, E. C., BEITINS, I. Z., & VAN WYK, J. J. (1981). Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-53-6-1247
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
