The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone
Open accessAbstract
OBJECTIVES: We investigated the effect of obesity on the serum levels of total and free IGF-1 and their relationship to the circulating levels of insulin and IGF binding proteins (IGFBPs) in age and sex-matched groups. SUBJECTS: The study included 43 obese subjects (ideal body weight; IBW>120%) and 45 controls (IBW<100%). All of the subjects were male. MEASUREMENT: Total IGF-1, free IGF-1, IGFBP-1, IGFBP-2, IGFBP-3, and insulin were measured in obese subjects and normal control subjects. RESULTS: No significant differences in the circulating levels of total and IGFBP-3 were observed between the obese and control groups. In contrast to total IGF-1, free IGF-1 in obese subjects was significantly increased compared to normal controls (P<0.05). Serum total and free IGF-1 were inversely correlated with age (r=−0.42, P=0.001, and −0.44, P=0.001). Fasting serum insulin concentrations were elevated in all the obese subjects (P<0.05) and positively correlated with IBW (r=0.57, P=0.001). The levels of serum GH and IGFBP-1 were suppressed in all the obese subjects (P<0.05). IGFBP-1 was inversely correlated with IBW (r=−0.51, P=0.001) and serum insulin concentrations (r=minus;0.48, P=0.001). The IGFBP-2 concentrations were also suppressed in obese subjects and inversely related to free IGF-1 (r=−0.48, P=0.001). Using multiple linear regression analysis, total IGF-1 and insulin concentrations were positively correlated (r=0.58, P=0.001) and free IGF-1 and IGFBP-1 concentrations were negatively correlated (r=−0.57, P=0.001). CONCLUSION: We confirmed that total IGF-1 and IGFBP-3 concentrations were not significantly different between the obese and control groups, despite GH hyposecretion in obesity. We also found that free IGF-1 concentrations were higher in obese subjects than in normal controls. It seems likely that overnutrition and chronic hyperinsulinaemia in obesity may alter this regulated growth response by insulin stimulation of IGF-1 production and suppression of hepatic IGFBP-1 and IGFBP-2 production, which may inhibit IGF-1 bioactivity.
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Cites
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Free insulin-like growth factors in human obesity
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Energy balance and cancer: the role of insulin and insulin-like growth factor-I
Kaaks, R., & Lukanova, A. (2001) · Proceedings of the Nutrition Society · doi:10.1079/pns200070 · Cited by 615
Acne vulgaris: a disease of Western civilization
Cordain, L., Lindeberg, S., Hurtado, M., Hill, K., Eaton, S. B., & Brand-Miller, J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.12.1584 · Cited by 500
Sandhu, M. S., Heald, A. H., Gibson, J. M., Cruickshank, J. K., Dunger, D. B., & Wareham, N. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08655-5 · Cited by 470
Obesity and cancer: existing and new hypotheses for a causal connection
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Metadata
- Authors
- Nam, S., Lee, E., Kim, K., Cha, B., Song, Y., Lim, S., Lee, H., & Huh, K.
- Venue
- International Journal of Obesity
- Published
- 1997-05
- Volume
- 21
- Issue
- 5
- Pages
- 355-359
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W1982836278
- Cited by
- 388
- References
- 13
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Nam, S., Lee, E., Kim, K., Cha, B., Song, Y., Lim, S., Lee, H., & Huh, K. (1997). Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. International Journal of Obesity. https://doi.org/10.1038/sj.ijo.0800412
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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