CoChat
Sign Up
Cited by 76Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentAdrenal Hormones and Disorders

Acute Effects of Propylthiouracil (PTU) on Thyroidal Iodide Organification and Peripheral Iodothyronine Deiodination: Correlation with Serum PTU Levels Measured by Radioimmunoassay*

COOPER, DAVID S., SAXE, VELIA C., MESKELL, MICHAEL, MALOOF, FARAHE, RIDGWAY, E. CHESTER·1982·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-54-1-101
Open this paper in CoChat — free account

Abstract

Propylthiouracil (PTU) levels in serum have been measured by RIA in five normal volunteers and four patients with untreated Graves' disease. Peak PTU levels after 50, 200, and 300 mg PTU were 0.91 ± 0.13, 2.9 ± 0.6, and 4.0 ± 0.6 jug/ml in the normal subjects and 1.04 ± 0.1, 4.5 ± 0.7, and 7.1 ± 0.4 jug/ml in the hyperthyroid patients, respectively. Peak PTU levels and PTU area under the curve were significantly greater at the 300-mg dose (P < 0.01) in the hyperthyroid patients compared to the normal subjects. The effect of PTU on iodide organification was assessed by perchlorate discharge testing. Both the normals and the hyperthyroid patients had normal basal perchlorate-dischargeable 123I. Four hours after an oral dose of PTU, the hyperthyroid patients had a greater percentage of perchlorate-dischargeable 123I than the euthyroid controls (+38 ± 5% vs. +13 ± 2% P < 0.02). There was a highly significant correlation between serum PTU levels and perchlorate-dischargeable iodide in both normals (r = 0.86; P < 0.001) and hyperthyroid patients (r =0.83; P < 0.001). T3 and rT3 were measured serially over 24 h after single oral doses of 50, 200, and 300 mg PTU. In normal volunteers, serum T3 declined slightly but significantly after the 200– and 300-mg doses; an increase in rT3 was also noted, but the changes did not attain statistical significance. In the hyperthyroid patients, serum T3 fell from 501 ± 29 to 379 ± 27 ng/dl after 50 mg PTU (P < 0.001), from 433 ± 40 to 264 ± 18 ng/dl after 200 mg PTU (P < 0.001), and from 463 ± 40 to 335 ± 18 ng/dl after 300 mg PTU (P < 0.05). Serum rT3 rose after each dose: from 119 ± 12 to 131 ± 11 ng/dl (P % NS) after 50 mg PTU, from 113 ± 11 to 146 ± 12 ng/dl (P < 0.02) after 200 mg PTU, and from 111 ± 14 to 154 ± 20 ng/dl (P < 0.02) after 300 mg PTU. These data suggest that PTU dosage correlates with measurable effects of the drug on both intrathyroidal iodide organification and peripheral iodothyronine deiodination. The determination of serum PTU levels by RIA may be useful in optimizing antithyroid drug therapy in selected cases.

Integrity signals

Registry

Crossref · 10.1210/jcem-54-1-101

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Therapeutic measures specifically intended to decrease T4-to-T3 conversion include preferential use of PTU over MMI, glucocorticoid therapy, and beta-adrenergic blocking agents such as propranolol with selective ability to inhibit type 1 deiodinase.

    “A number of therapeutic measures are specifically intended to decrease T 4 -to-T 3 conversion, such as the preferential use of PTU over MMI (229,230), glucocorticoid therapy (231), and the use of b-adrenergic blocking agents such as propranolol, with selective ability to inhibit type 1 deiodinase (232).”

    From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [230]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
COOPER, D. S., SAXE, V. C., MESKELL, M., MALOOF, F., & RIDGWAY, E. C.
Affiliations
Harvard University (US)
ORCID
COOPER, DAVID S.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1982-01
Volume
54
Issue
1
Pages
101-107
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-54-1-101
OpenAlex
W2082395479
Cited by
76
References
41
Citations by year
2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 1
FWCI
4.75
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
propylthiouracil, Graves' disease, hyperthyroidism, serum drug concentration, triiodothyronine, reverse T3, dose-response relationship, thyroid hormone synthesis inhibition
MeSH terms
Adult, Female, Graves Disease, Humans, Iodine, Iodine Radioisotopes, Kinetics, Male, Perchlorates, Potassium, Propylthiouracil, Thyroid Gland, Thyroxine, Triiodothyronine, Triiodothyronine, Reverse, Potassium Compounds

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review