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Adrenocortical function in old age: response to acute adrenocorticotropin stimulation.
Abstract
To elucidate the controversial point whether, in analogy with delta 5-steroid secretion, adrenal delta 4-steroid secretion is significantly decreased in elderly persons, we studied the response of plasma levels of both delta 5-steroids (dehydroepiandrosterone, 17-hydroxypregnenolone, and pregnenolone) and delta 4-steroids (cortisol, androstenedione, 17-hydroxyprogesterone, and progesterone) to acute ACTH stimulation in four groups of young and elderly males and females, respectively. To study the possible influence of sex hormones on adrenocortical function in elderly persons, we performed the same study in male with prostatic carcinoma treated with estrogens. The data show that in elderly persons, the response of plasma delta 4-steroids to ACTH stimulation is comparable or higher than that in young subjects, whereas the response of delta 5-steroids is significantly decreased; estrogen treatment does not change this pattern. It is concluded that in elderly persons adrenal delta 4-steroid secretory capacity is unimpaired, whereas delta 5-steroid secretion is significantly decreased. The responsible mechanism remains to be elucidated.
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From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [18]
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Metadata
- Authors
- VERMEULEN, A., DESLYPERE, J. P., SCHELFHOUT, W., VERDONCK, L., & RUBENS, R.
- Affiliations
- Ghent University Hospital (BE)
- ORCID
- VERMEULEN, A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1982-01
- Volume
- 54
- Issue
- 1
- Pages
- 187-191
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2062452627
- Cited by
- 135
- References
- 0
- Citations by year
- 2025: 2 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- adrenocortical function, aging, older adults, ACTH stimulation test, adrenal steroid secretion, dehydroepiandrosterone, pregnenolone, cortisol, sex hormones, estrogen therapy, prostate cancer, age-related decline
- MeSH terms
- Adolescent, Adrenal Cortex, Adrenocorticotropic Hormone, Adult, Aged, Aging, Androstenedione, Dehydroepiandrosterone, Female, Humans, Hydrocortisone, 17-alpha-Hydroxypregnenolone, Hydroxyprogesterones, Male, Middle Aged, Pregnenolone, Progesterone
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