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Adrenocortical function in old age: response to acute adrenocorticotropin stimulation.
Abstract
To elucidate the controversial point whether, in analogy with delta 5-steroid secretion, adrenal delta 4-steroid secretion is significantly decreased in elderly persons, we studied the response of plasma levels of both delta 5-steroids (dehydroepiandrosterone, 17-hydroxypregnenolone, and pregnenolone) and delta 4-steroids (cortisol, androstenedione, 17-hydroxyprogesterone, and progesterone) to acute ACTH stimulation in four groups of young and elderly males and females, respectively. To study the possible influence of sex hormones on adrenocortical function in elderly persons, we performed the same study in male with prostatic carcinoma treated with estrogens. The data show that in elderly persons, the response of plasma delta 4-steroids to ACTH stimulation is comparable or higher than that in young subjects, whereas the response of delta 5-steroids is significantly decreased; estrogen treatment does not change this pattern. It is concluded that in elderly persons adrenal delta 4-steroid secretory capacity is unimpaired, whereas delta 5-steroid secretion is significantly decreased. The responsible mechanism remains to be elucidated.
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“Serum androgens as well as their precursors and metabolites decrease from the age of 30 -40 yr in women”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [18]
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The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
“It has been observed that after acute stimulation with ACTH, the serum DHEA response is manifestly diminished in the elderly, whereas the cortisol response is similar to that in young men (113, 114).”
ResultSelf-citationKudielka, B. M., Hellhammer, D. H., & Wüst, S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.004 · Cited by 963
“…synthetic or extracted ACTH does not point to a generally altered adrenal cortex capacity or sensitivity with progressive age (Kley et al., 1975; Parker et al., 1981, 2000; Vermeulen et al., 1982; Ohashi et al., 1986b; Roberts et al., 1990; Rasmuson et al., 1998; Martinez-Taboada et al., 2002).”
BackgroundA prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease.
Barrett-Connor, E., Khaw, K.-T., & Yen, S. S. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612113152405 · Cited by 681
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544
Vermeulen, A. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.5.1821 · Cited by 455
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Metadata
- Authors
- VERMEULEN, A., DESLYPERE, J. P., SCHELFHOUT, W., VERDONCK, L., & RUBENS, R.
- Affiliations
- Ghent University Hospital (BE)
- ORCID
- VERMEULEN, A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1982-01
- Volume
- 54
- Issue
- 1
- Pages
- 187-191
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2062452627
- Cited by
- 135
- References
- 0
- Citations by year
- 2025: 2 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- adrenocortical function, aging, older adults, ACTH stimulation test, adrenal steroid secretion, dehydroepiandrosterone, pregnenolone, cortisol, sex hormones, estrogen therapy, prostate cancer, age-related decline
- MeSH terms
- Adolescent, Adrenal Cortex, Adrenocorticotropic Hormone, Adult, Aged, Aging, Androstenedione, Dehydroepiandrosterone, Female, Humans, Hydrocortisone, 17-alpha-Hydroxypregnenolone, Hydroxyprogesterones, Male, Middle Aged, Pregnenolone, Progesterone
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