Cited by 228Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesRegulation of Appetite and Obesity

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Insulin-Like Growth Factors in the Fed and Fasted States*

MERIMEE, THOMAS J., ZAPF, J., FROESCH, E. R.·1982·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-55-5-999

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Abstract

The effect of GH administration (5 mg twice daily for 5 days) on the serum concentration of insulin-like growth factors I and II (IGF I and IGF II) was compared in GH-deficient subjects during a period of fasting and a period of normal food intake. Before treatment with GH, the mean concentration of IGF I was 35.2 +/- 7.5 ng/ml. After 5 days of GH treatment in the fed state, IGF I increased nearly 10-fold to 317.4 +/- 55.9 ng/ml (P less than 0.001 vs. pretreatment value). During fasting, identical treatment of the group resulted in only a modest increase of IGF I to 81 +/- 23 ng/ml (P less than 0.001 vs. fed state response). The serum concentration of IGF II before therapy was reduced to only 174 +/- 37 ng/ml. With GH given in the fed state, IGF II increased to 793 +/- 171 ng/ml. These data suggest that IGF II, like IGF I, is GH dependent and, hence, a somatomedin. GH therapy in the fasted state increased IGF II to 437 +/- 70 ng/ml (P = 0.05 vs. fed state response). In a second study, six normal subjects were fasted for 72 h. The integrated serum IGF I concentration (24 samples/subject) decreased 42% by the third day of fasting; IGF II decreased 27% during the same period. The data from both studies are consistent with the conclusion that the metabolic milieu of fasting inhibits IGF secretion in man. IGF I appears to be affected more than IGF II.

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Authors: MERIMEE, T. J., ZAPF, J., & FROESCH, E. R.
Affiliations: University of Florida Health (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1982-11
Volume: 55
Issue: 5
Pages: 999-1002
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-55-5-999
OpenAlex: W2034387252
Cited by: 228
References: 21
Citations by year: 2025: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 5
FWCI: 4.13
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: insulin-like growth factor I, insulin-like growth factor II, growth hormone, fasting, dietary intake, GH deficiency, insulin-like growth factor
MeSH terms: Adult, Dwarfism, Pituitary, Fasting, Female, Food, Humans, Insulin, Male, Middle Aged, Somatomedins, Growth Hormone

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Insulin-Like Growth Factors in the Fed and Fasted States*

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