The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Insulin-Like Growth Factors in the Fed and Fasted States*
Abstract
The effect of GH administration (5 mg twice daily for 5 days) on the serum concentration of insulin-like growth factors I and II (IGF I and IGF II) was compared in GH-deficient subjects during a period of fasting and a period of normal food intake. Before treatment with GH, the mean concentration of IGF I was 35.2 +/- 7.5 ng/ml. After 5 days of GH treatment in the fed state, IGF I increased nearly 10-fold to 317.4 +/- 55.9 ng/ml (P less than 0.001 vs. pretreatment value). During fasting, identical treatment of the group resulted in only a modest increase of IGF I to 81 +/- 23 ng/ml (P less than 0.001 vs. fed state response). The serum concentration of IGF II before therapy was reduced to only 174 +/- 37 ng/ml. With GH given in the fed state, IGF II increased to 793 +/- 171 ng/ml. These data suggest that IGF II, like IGF I, is GH dependent and, hence, a somatomedin. GH therapy in the fasted state increased IGF II to 437 +/- 70 ng/ml (P = 0.05 vs. fed state response). In a second study, six normal subjects were fasted for 72 h. The integrated serum IGF I concentration (24 samples/subject) decreased 42% by the third day of fasting; IGF II decreased 27% during the same period. The data from both studies are consistent with the conclusion that the metabolic milieu of fasting inhibits IGF secretion in man. IGF I appears to be affected more than IGF II.
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“fasting decreases IGF-1 levels despite elevated GH levels, most likely because of changes in other determinants of its secretion, such as hormones (insulin) and nutritional status per se as well as GH resistance in the liver (18, 45).”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [45]
Citations
Cites
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Self-citationReduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*
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Items 201–228 of 228
Insulin-like Growth Factor-I et dénutrition aiguë ou chronique
Wolf, S. E., Ramirez, R. J., & Herndon, D. N. (1996) · Nutrition Clinique et Métabolisme · doi:10.1016/s0985-0562(96)80006-9 · Cited by 1
Jeevanandam, M. (1996) · Nutrition Clinique et Métabolisme · doi:10.1016/s0985-0562(96)80005-7 · Cited by 1
Somatomedins: Biochemical and Physiological Aspects
D’Ercole, A. J. (1991) · Springer eBooks · doi:10.1007/978-1-4684-0400-5_7 · Cited by 1
Nakago, S., Morikawa, H., Mochizuki, M., & Ueda, Y. (1994) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.70.2_85 · Cited by 1
Regulation of Insulin-like Growth Factor-I by Nutrition
Ketelslegers, J. M., Thissen, J. P., Maiter, D. M., Fliesen, T., Mauerhoff, T., Triest, S., Moats‐Staats, B. M., Maes, M., & Underwood, L. E. (1993) · Springer eBooks · doi:10.1007/978-3-642-78217-6_8 · Cited by 1
Cimino, R. L. (2013) · University of North Florida Digital Commons (University of North Florida) · Cited by 1
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Caju, M. V. L. D. (1989) · Springer eBooks · doi:10.1007/978-1-4613-0753-2_56 · Cited by 1
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Snyder, D. K. (1995) · Springer eBooks · doi:10.1007/978-1-4612-0807-5_19 · Cited by 1
Regulation of Insulin-Like Growth Factor-I and its Role in Controlling Growth and Metabolism
Clemmons, D. R. (1999) · Endocrine updates · doi:10.1007/978-1-4615-5163-8_4
The utility of resting levels of IGF-I and IGFBP-3 as markers of training status in elite athletes
Bischler, T. K. (2007) · Open ULeth Scholarship (OPUS) (University of Lethbridge)
The Somatomedin Hypothesis of Growth Hormone Action
Hintz, R. L. (1999) · Comprehensive physiology · doi:10.1002/cphy.cp070515
Targeting the GH/IGF-1 axis with novel, small molecule inhibitors
Rosengren, L. (2007) · Figshare
Schmidt, K. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-5597
Identification and evaluation of growth hormone antagonists
Rosengren, L. (2005) · Figshare
Growth Hormone And Nutritional Status
Scacchi, M., Pincelli, A. I., & Cavagnini, F. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1579-1_15
Endocrine Testing in Acute and Critical Illness
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Lee, C. D., Safdie, F. M., Raffaghello, L., Wei, M., Madia, F., Parrella, E., Hwang, D., Cohen, P., Bianchi, G., & Longo, V. D. (2023) · doi:10.1158/0008-5472.c.6500778
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The Regulation of Growth by Insulinlike Growth Factor II
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Self-citationThe Regulation of Amino Acid and Protein Metabolism by Growth Hormone
Fryburg, D. A., & Barrett, E. J. (1998) · Comprehensive physiology · doi:10.1002/j.2040-4603.1998.tb01547.x
The Somatomedin Hypothesis of Growth Hormone Action
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Liver Receptors for Regulatory Peptides
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Chen, Z. (1996) · UA Campus Repository (The University of Arizona)
Metadata
- Authors
- MERIMEE, T. J., ZAPF, J., & FROESCH, E. R.
- Affiliations
- University of Florida Health (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1982-11
- Volume
- 55
- Issue
- 5
- Pages
- 999-1002
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2034387252
- Cited by
- 228
- References
- 21
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 5
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- insulin-like growth factor I, insulin-like growth factor II, growth hormone, fasting, dietary intake, GH deficiency, insulin-like growth factor
- MeSH terms
- Adult, Dwarfism, Pituitary, Fasting, Female, Food, Humans, Insulin, Male, Middle Aged, Somatomedins, Growth Hormone
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