Cited by 209Menopause: Health Impacts and TreatmentsBone health and osteoporosis researchEstrogen and related hormone effects

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Pathophysiological mechanisms of estrogen effect on bone metabolism. Dose-response relationships in early postmenopausal women.

CHRISTIANSEN, CLAUS, CHRISTENSEN, MERETE SANVIG, LARSEN, NIELS-ERIK, TRANSBØL, IB·1982·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-55-6-1124

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Abstract

Dose-response relationships of estrogen (E) on indices of calcium balance and bone activity were studied in normal early postmenopausal women. Calcium balance was estimated by changes in forearm bone mineral content, measured by photon absorptiometry. Bone activity was estimated by serum alkaline phosphatases (S-aPh), indicating bone formation, and by fasting urinary excretion of hydroxyproline (U-HyPro) and calcium (U-Ca), indicating bone resorption. A total of 92 female volunteers were randomized to 12 months' treatment with placebo or one of three different doses (high, medium, or low) of natural estrogens (17 beta-estradiol and estriol, 4/2, 2/1, and 1/0.5 mg, respectively), sequentially combined with the same dose (1 mg) of norethisterone acetate for 10 of the 28 cycle days. The trial was completed by 79 women. Bone mineral content declined by 2% (P less than 0.001) in the placebo group, remained constant in the low hormone group and increased by 0.8% (P less than 0.05) and 1.5% (P less than 0.01), respectively, in the medium and high hormone groups. S-aPh decreased gradually and equally by 20-25% in the three hormone groups and U-HyPro and U-Ca decreased by 30-40% during 1-yr hormone treatment, irrespective of dose. The decrease in these three indices occurred practically without exceptions. Compared to the values found in 48 normal premenopausal women the untreated postmenopausal women had increased values of S-aPh (P less than 0.001), U-HyPro (P less than 0.01), and U-Ca (P less than 0.001), and no pretreatment values were below the normal premenopausal range. After treatment the mean values of S-aPh and U-HyPro were slightly lower than the premenopausal mean values (P less than 0.01). These data strongly support the major importance of E deficiency for early postmenopausal bone loss, which is prevented by even a small substitution dose of E.

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Recker, R. R., Saville, P. D., & Heaney, R. P. (1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-6-649 · Cited by 563
Menopausal changes in calcium balance performance
Heaney, R. P., Recker, R. R., & Omaha, P. D. S. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1983.tb07709.x · Cited by 531
Voluntary Medical Care Insurance in the United States
(1949) · JAMA · doi:10.1001/jama.1949.02900460063032 · Cited by 459
POST-MENOPAUSAL $OElig;STROGENS PROTECT AGAINST FRACTURES OF HIP AND DISTAL RADIUS A Case-control Study
HUTCHINSON, T. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90640-8 · Cited by 452
Menopausal changes in bone remodeling.
Heaney, R. P., Recker, R. R., & Saville, P. D. (1978) · PubMed · Cited by 435
Estrogen replacement therapy I: a 10-year prospective study in the relationship to osteoporosis.
Nachtigall, L. E., Nachtigall, R. H., Nachtigall, R. D., & Beckman, E. M. (1979) · PubMed · Cited by 374
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Melsen, F., & Mosekilde, L. (1978) · Calcified Tissue International · doi:10.1007/bf02013242 · Cited by 232
A unified concept of osteoporosis
Heaney, R. P. (1965) · The American Journal of Medicine · doi:10.1016/0002-9343(65)90109-9 · Cited by 189
Bone remodeling and calcium metabolism: A correlated histomorphometric, calcium kinetic, and biochemical study in patients with osteoporosis and Paget's disease
Lauffenburger, T., Olah, A. J., Dambacher, M. A., Guncaga, J., Lentner, C., & HAAS, H. G. (1977) · Metabolism · doi:10.1016/0026-0495(77)90081-6 · Cited by 120
Long-term reproducibility of bone mineral content measurements
Christiansen, C. B., & Roödbro, P. (1977) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517709092636 · Cited by 113
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Modèles animaux d'ostéoporose post-ménopausique
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Clinical practice guidelines for the diagnosis and management of osteoporosis. Scientific Advisory Board, Osteoporosis Society of Canada.
(1996) · PubMed Central · Cited by 33
Low doses of estradiol in combination with gestodene to prevent early postmenopausal bone loss
Bjarnason, N. H., Byrjalsen, I., Hassager, C., Haarbo, J., & Christiansen, C. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.106595 · Cited by 34
Self-citation
Effects of Foeniculum vulgare ethanol extract on osteogenesis in human mecenchymal stem cells.
Mahmoudi, Z., Soleimani, M., Saidi, A., Khamisipour, G., & Azizsoltani, A. (2013) · Europe PMC (PubMed Central) · Cited by 33
Spironolactone, But Not Flutamide, Administration Prevents Bone Loss in Hyperandrogenic Women Treated with Gonadotropin-Releasing Hormone Agonist1
Moghetti, P., Castello, R., Zamberlan, N., Rossini, M., Gatti, D., Negri, C., Tosi, F., Muggeo, M., & Adámi, S. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.4.5606 · Cited by 33
Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat
Lea, C. K., & Flanagan, A. M. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.2.e328 · Cited by 33
Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats
Sato, F., Ouchi, Y., Masuyama, A., Nakamura, T., Hosoi, T., Okamoto, Y., Sasaki, N., Shiraki, M., & Orimo, H. (1993) · Calcified Tissue International · doi:10.1007/bf01321888 · Cited by 33
Influence of oestrogen and androgen on modelling of the mandibular condylar bone in ovariectomized and orchiectomized growing mice
Fujita, T., Kawata, T., Tokimasa, C., & Tanne, K. (2001) · Archives of Oral Biology · doi:10.1016/s0003-9969(00)00094-7 · Cited by 32
Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats
Takagi, T., Yamamoto, T., Asano, S., & Tamaki, H. (1993) · Calcified Tissue International · doi:10.1007/bf00571334 · Cited by 32
A randomized double blind placebo controlled trial of the effects on bone metabolism of the combination of nafarelin acetate and norethisterone
Eldred, J., Haynes, P. J., & Thomas, E. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02338.x · Cited by 32
Is There Any Association Between the Presence of Bone Disease and Cumulative Exposure to Lead?
Adachi, J. D., Arlen, D. J., Webber, C. E., Chettle, D. R., Beaumont, L. F., & Gordon, C. L. (1998) · Calcified Tissue International · doi:10.1007/s002239900552 · Cited by 31
The Combination of a Novel Selective Estrogen Receptor Modulator with an Estrogen Protects the Mammary Gland and Uterus in a Rodent Model: The Future of Postmenopausal Women’s Health?
Labrie, F., Elalfy, M., Berger, L., Labrie, C., Martel, C., Bélanger, A., Candas, B., & Pelletier, G. (2003) · Endocrinology · doi:10.1210/en.2003-0269 · Cited by 31
Ovarian androgens protect against bone loss in rats made oestrogen deficient by treatment with ICI 182,780
Lea, C. K., & Flanagan, A. M. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600111 · Cited by 31
Renal leak of calcium in post‐menopausal osteoporosis
Nordin, B. E. C., Horowitz, M., Need, A. G., & Morris, H. A. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb03782.x · Cited by 31
Serum Alkaline Phosphatase During Hormone Treatment in Early Postmenopausal Women
Christiansen, C., Rødbro, P., & Tjellesen, L. (1984) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1984.tb03764.x · Cited by 29
Self-citation
Serum bone Gla protein variations during estrogen and calcium prophylaxis of postmenopausal women
Pødenphant, J., Christiansen, C., Catherwood, B. D., & Deftos, L. J. (1984) · Calcified Tissue International · doi:10.1007/bf02405361 · Cited by 29
Self-citation
Oestrogen‐activated autophagy has a negative effect on the anti‐osteoclastogenic function of oestrogen
Cheng, L., Zhu, Y., Xie, D., & Ke, D. (2020) · Cell Proliferation · doi:10.1111/cpr.12789 · Cited by 28
Main endocrine modulators of vitamin D hydroxylases in human pathophysiology
Lorè, A. C., Cairano, G. D., & Nuti, R. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90154-3 · Cited by 28
Sex steroids and osteoporosis: Effects of deficiencies and substitutive treatments
Schot, L. P. C., & Schuurs, A. H. W. M. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90325-f · Cited by 27
Short-Term effects of high dose estrogen on tibiae of growing male rats
Wakley, G. K., Evans, G. L., & Turner, R. T. (1997) · Calcified Tissue International · doi:10.1007/s002239900183 · Cited by 28
Stimulation of bone formation by dynamic mechanical loading of rat caudal vertebrae is not suppressed by 3-amino-1-hydroxypropylidene-1-bisphosphonate (AHPrBP)
Jagger, C., Chambers, T. J., & Chow, J. W. M. (1995) · Bone · doi:10.1016/8756-3282(94)00043-3 · Cited by 27
Bioequivalence assessment of three different estradiol formulations in postmenopausal women in an open, randomized, single-dose, 3-way cross-over study
Timmer, C. J., & Geurts, T. B. P. (1999) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03190010 · Cited by 26
Cimetidine inhibits catechol estrogen metabolism in women
Michnovicz, J. J., & Galbraith, R. A. (1991) · Metabolism · doi:10.1016/0026-0495(91)90169-w · Cited by 26
Estrogen-induced osteogenesis in intact female mice lacking ERβ
McDougall, K. E., Perry, M. J., Gibson, R., Bright, J. M., Colley, S. M., Hodgin, J. B., Smithies, O., & Tobias, J. H. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00071.2002 · Cited by 26

Authors: CHRISTIANSEN, C., CHRISTENSEN, M. S., LARSEN, N.-E., & TRANSBØL, I.
Affiliations: University of Copenhagen (DK)
ORCID: CHRISTIANSEN, CLAUS
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1982-12
Volume: 55
Issue: 6
Pages: 1124-1130
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-55-6-1124
OpenAlex: W2059782675
Cited by: 209
References: 13
Citations by year: 2026: 1 · 2020: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 2
FWCI: 4.88
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: estrogen, bone metabolism, postmenopausal bone loss, estrogen dose-response, estradiol, estriol, norethisterone acetate, calcium balance, bone mineral content, bone formation, bone resorption, alkaline phosphatase, urinary hydroxyproline, urinary calcium, hormone replacement therapy
MeSH terms: Adult, Alkaline Phosphatase, Bone and Bones, Calcium, Dose-Response Relationship, Drug, Estrogens, Female, Humans, Hydroxyproline, Menopause, Middle Aged, Minerals, Phosphates

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Pathophysiological mechanisms of estrogen effect on bone metabolism. Dose-response relationships in early postmenopausal women.

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