Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina and endometrium in postmenopausal women.
Abstract
The effect of 12-month dehydroepiandrosterone (DHEA) replacement therapy has been evaluated in 14 60- to 70-yr-old women who received daily applications of a 10% DHEA cream. Vaginal epithelium maturation was stimulated by DHEA administration in 8 of 10 women who had a maturation value of zero at the onset of therapy, whereas a stimulatory effect was also seen in all three women who had an intermediate vaginal maturation index before therapy. The estrogenic effect of DHEA observed in the vagina was not observed in the endometrium, which remained atrophic in all women. Most interesting, the bone mineral density significantly increased at the hip from 0.744 +/- 0.021 to 0.759 +/- 0.025 g/cm2 after 12 months of treatment (P < 0.05). These changes in bone mineral density were associated with a significant 20.0% decrease (P < 0.01) in plasma bone alkaline phosphatase and a 28% decrease in the urinary hydroxyproline/creatinine ratio. A 2.1-fold increase over the control value (P < 0.01) in plasma osteocalcin was concomitantly observed. The present data describe for the first time a series of medically important beneficial effects of DHEA therapy in postmenopausal women through transformation of the precursor steroid DHEA into androgens and/or estrogens in specific peripheral intracrine tissues without significant adverse effects. The stimulatory effect on the vaginal epithelium in the absence of stimulation of the endometrium is of particular interest because it eliminates the need for progestin replacement therapy. On the other hand, the stimulatory effect on bone mineral density accompanied by an increase in serum osteocalcin, a marker of bone formation, suggests stimulation of bone formation by the androgenic action of DHEA, a finding of particular interest for both the prevention and treatment of osteoporosis.
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Other studies of DHEA therapy in postmenopausal women or aging have also shown selective improvement in BMD at the femoral neck.
“second, other studies of DHEA therapy in postmenopausal women (9) or aging (40,47) have also shown selective improvement in BMD at this site.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [9]
The Bone density section (page unavailable) reports a significant BMD increase at the total hip after DHEA treatment, but not at the femoral neck specifically. Ward’s triangle, an area near the femoral neck, increased without reaching statistical significance. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPositive effects of DHEA replacement have been described on psychological well-being, body composition, and bone mineral density in older, normal adults.
“positive effects of DHEA replacement have been described on psychological well-being (6), body composition (7,8), and bone mineral density (BMD) (9) in older, normal adults.”
From Long-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial (2008) · cites this paper as [9]
Absence of a stimulatory effect of DHEA on human endometrium eliminates the need to administer a progestin to neutralize the stimulatory effect of estrogens in this tissue.
“the absence of a stimulatory effect of DHEA on the human endometrium (73, 280) eliminates the need to administer a progestin to neutralize the stimulatory effect of estrogens in this tissue.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
Bone mass density was increased by 2.3% at the hip, 3.75% at the hip Ward's triangle, and 2.2% at the lumbar spine level in 60- to 70-yr-old women after 12 months of DHEA.
“Bone mass density was increased by 2.3% at the hip, 3.75% at the hip Ward's triangle, and 2.2% at the lumbar spine level (all P Ͻ 0.05; Ref. 280).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
Women at menopause are not only deprived from estrogens because of rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of progressive decrease of serum DHEA levels starting years before menopause.
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
The estrogenic stimulatory effect observed in the vagina was not found in the endometrium, which remained completely atrophic in all women after 12 months of DHEA treatment.
“the estrogenic stimulatory effect observed in the vagina was not found in the endometrium, which remained completely atrophic in all women after 12 months of DHEA treatment (280).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
Serum levels of DHEA using a 10% cream were comparable to those obtained after daily oral administration of 100 mg of DHEA.
“We have also determined that the serum levels of DHEA using a 10% cream (280) were comparable to the ones obtained after daily oral administration of 100 mg of DHEA (our unpublished data).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [280]
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Cites
The use of estrogens and progestins and the risk of breast cancer in postmenopausal women.
Colditz, G. A., Hankinson, S. E., Hunter, D. J., Willett, W. C., Manson, J. E., Stampfer, M. J., Hennekens, C., Rosner, B., & Speizer, F. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506153322401 · Cited by 1,487 · see citing works
ORENTREICH, N., BRIND, J. L., RIZER, R. L., & VOGELMAN, J. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-3-551 · Cited by 1,349 · see citing works
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841 · see citing works
Determination of serum creatinine by a direct colorimetric method
Heinegård, D. K., & Tiderström, G. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90466-x · Cited by 724 · see citing works
Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713 · see citing works
Self-citationA prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease.
Barrett-Connor, E., Khaw, K.-T., & Yen, S. S. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612113152405 · Cited by 681 · see citing works
The Functions of Corticosteroid-Binding Globulin and Sex Hormone-Binding Globulin: Recent Advances*
Rosner, W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-1-80 · Cited by 560 · see citing works
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553 · see citing works
Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality
Davis, S. R., McCloud, P., Strauss, B. J., & Burger, H. (1995) · Maturitas · doi:10.1016/0378-5122(94)00898-h · Cited by 534 · see citing works
The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00174-2 · Cited by 480 · see citing works
Self-citationChanges in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men
Bèlanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.-L., & Labrie, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962278 · Cited by 437 · see citing works
Self-citationNESTLER, J. E., BARLASCINI, C. O., CLORE, J. N., & BLACKARD, W. G. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-57 · Cited by 414 · see citing works
The epidemiology of endometrial cancer
Parazzini, F., Vecchia, C. L., Bocciolone, L., & Franceschi, S. (1991) · Gynecologic Oncology · doi:10.1016/0090-8258(91)90246-2 · Cited by 398 · see citing works
The role of androgen in the maintenance of sexual functioning in oophorectomized women.
Sherwin, B. B., & Gelfand, M. M. (1987) · Psychosomatic Medicine · doi:10.1097/00006842-198707000-00009 · Cited by 394 · see citing works
Labrie, F., Bélanger, A., Cusan, L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4161 · Cited by 350 · see citing works
Self-citationTherapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.
Coleman, D. L., Leiter, E. H., & Schwizer, R. W. (1982) · Diabetes · doi:10.2337/diab.31.9.830 · Cited by 317 · see citing works
Comparison of pharmacodynamic properties of various estrogen formulations
Mashchak, C. A., Lobo, R. A., Dozono-Takano, R., Eggena, P., Nakamura, R. M., Brenner, P. F., & Mishell, D. R. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(82)90218-6 · Cited by 316 · see citing works
Complete androgen blockade for the treatment of prostate cancer.
Labrie, F., Dupont, A., & Bèlanger, A. (1985) · PubMed · Cited by 285 · see citing works
Self-citationDHEA and peripheral androgen and estrogen formation: intracrinology
LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17369.x · Cited by 280 · see citing works
Self-citationDehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells.
Suzuki, T., Suzuki, N., Daynes, R. A., & Engleman, E. G. (1991) · Clinical Immunology and Immunopathology · doi:10.1016/s0090-1229(05)80024-8 · Cited by 277 · see citing works
Sherwin, B. B., & Gelfand, M. M. (1985) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(85)90001-8 · Cited by 261 · see citing works
MIGEON, C. J., KELLER, A. R., LAWRENCE, B., & SHEPARD, T. H. (1957) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-17-9-1051 · Cited by 260 · see citing works
Affective changes with estrogen and androgen replacement theraphy in surgically menopausal women
Sherwin, B. B. (1988) · Journal of Affective Disorders · doi:10.1016/0165-0327(88)90061-4 · Cited by 258 · see citing works
Effect of testosterone on abdominal adipose tissue in men.
Rebuffé-Scrive, M., Mårin, P., & Björntorp, P. A. (1991) · PubMed · Cited by 227 · see citing works
Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women
Casson, P. R., Andersen, R. N., Herrod, H. G., Stentz, F. B., Straughn, A. B., Abraham, G. E., & Buster, J. E. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90431-h · Cited by 211 · see citing works
CHRISTIANSEN, C., CHRISTENSEN, M. S., LARSEN, N.-E., & TRANSBØL, I. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-6-1124 · Cited by 209 · see citing works
The short-term effects of conjugated estrogen on bone turnover in older women.
Prestwood, K. M., Pilbeam, C. C., Burleson, J., Woodiel, F. N., Delmas, P. D., Deftos, L. J., & Raisz, L. G. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.2.8045949 · Cited by 196 · see citing works
Burger, H., Hailes, J., Menelaus, M., Nelson, J., Hudson, B., & Balazs, N. D. H. (1984) · Maturitas · doi:10.1016/0378-5122(84)90008-2 · Cited by 187 · see citing works
Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women.
Burger, H., Hailes, J., Nelson, J., & Menelaus, M. (1987) · BMJ · doi:10.1136/bmj.294.6577.936 · Cited by 178 · see citing works
Cusan, L., Dupont, A., Gomez, J., Tremblay, R. R., & Labrie, F. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56518-2 · Cited by 177 · see citing works
Self-citationReduced testosterone and adrenal C19 steroid levels in obese men
Tchernof, A., Després, J.-P., Bélanger, A., Dupont, A., Prud'homme, D., Moorjani, S., Lupien, P. J., & Labrie, F. (1995) · Metabolism · doi:10.1016/0026-0495(95)90060-8 · Cited by 175 · see citing works
Self-citationAndrogenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate.
LABRIE, C., BELANGER, A., & LABRIE, F. (1988) · Endocrinology · doi:10.1210/endo-123-3-1412 · Cited by 167 · see citing works
Self-citationModulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone.
Gordon, G. B., Shantz, L. M., & Talalay, P. (1987) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(87)90023-9 · Cited by 159 · see citing works
NATURAL ŒSTROGEN AS AN EFFECTIVE TREATMENT FOR TYPE-II HYPERLIPOPROTEINÆMIA IN POSTMENOPAUSAL WOMEN
Tikkanen, M., Nikkilä, E., & Vartiainen, E. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92216-x · Cited by 149 · see citing works
BARDON, S., VIGKPN, F., CHALBOS, D., & ROCHEFORT, H. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-4-692 · Cited by 143 · see citing works
Treatment of hirsutism with the pure antiandrogen flutamide
Cusan, L., Dupont, A., Bélanger, A., Tremblay, R. R., Manhès, G., & Labrie, F. (1990) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(90)70241-9 · Cited by 140 · see citing works
Self-citationAdrenocortical function in old age: response to acute adrenocorticotropin stimulation.
VERMEULEN, A., DESLYPERE, J. P., SCHELFHOUT, W., VERDONCK, L., & RUBENS, R. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-1-187 · Cited by 135 · see citing works
An easy and reliable method for determination of urinary hydroxyproline
Pødenphant, J., Larsen, N., & Christiansen, C. (1984) · Clinica Chimica Acta · doi:10.1016/0009-8981(84)90110-4 · Cited by 135 · see citing works
Zumoff, B., Levin, J., Rosenfeld, R. S., Markham, M. J., Strain, G. W., & Fukushima, D. K. (1981) · PubMed · Cited by 123 · see citing works
A Review of the Prolonged Use of Estrogens and Androgens in Postmenopausal and Senile Osteoporosis
Henneman, P. H. (1957) · Archives of Internal Medicine · doi:10.1001/archinte.1957.00260110031005 · Cited by 122 · see citing works
Pochi, P. E., & Strauss, J. S. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.4 · Cited by 120 · see citing works
Weinstein, L., Bewtra, C., & Gallagher, J. C. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90917-v · Cited by 119 · see citing works
Characterization, Expression, and Immunohistochemical Localization of 5α-Reductase in Human Skin
Luu-The, V., Sugimoto, Y., Puy, L., Labrie, Y., Solache, I. L., Singh, M., & Labrie, F. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371766 · Cited by 118 · see citing works
Self-citationSchriock, E. D., Buffington, C. K., Hubert, G. D., Kurtz, B. R., Kitabchi, A. E., Buster, J. E., & Givens, J. R. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-6-1329 · Cited by 115 · see citing works
Plasma lipids and lipoprotein cholesterol concentrations in people with different diets in Britain.
Thorogood, M., Carter, R., Benfield, L., McPherson, K., & Mann, J. I. (1987) · BMJ · doi:10.1136/bmj.295.6594.351 · Cited by 107 · see citing works
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice
Coleman, D., Leiter, E. H., & Schwizer, R. W. (1982) · Diabetes · doi:10.2337/diabetes.31.9.830 · Cited by 103 · see citing works
Inhibition of tumor development by dehydroepiandrosterone and related steroids.
Schwartz, A. G., Pashko, L., & Whitcomb, J. M. (1986) · Toxicologic Pathology · doi:10.1177/019262338601400312 · Cited by 101 · see citing works
Studd, J. W. W., Collins, W. P., Chakravarti, S., Newton, R., Oram, D. H., & Parsons, A. (1977) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1977.tb12586.x · Cited by 99 · see citing works
Dumont, M., Luu-The, V., Dupont, É., Pelletier, G., & Labrie, F. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12616131 · Cited by 95 · see citing works
Self-citationSavvas, M., Studd, J. W. W., Fogelman, I., Dooley, M., Montgomery, J., & Murby, B. (1988) · BMJ · doi:10.1136/bmj.297.6644.331 · Cited by 91 · see citing works
The short-term effects of conjugated estrogen on bone turnover in older women
Prestwood, K. M. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.2.366 · Cited by 88 · see citing works
Need, A. G. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390010075007 · Cited by 85 · see citing works
Parker, C. R., Simpson, E. R., Bilheimer, D. W., Leveno, K. J., Carr, B. R., & MacDonald, P. C. (1980) · Science · doi:10.1126/science.6445079 · Cited by 75 · see citing works
The use of Estrogens and Progestins and the Risk of Breast Cancer in Postmenopausal Women
Colditz, G. A., Hankinson, S. E., Hunter, D. J., Willett, W. C., Manson, J. E., Stampfer, M. J., Hennekens, C. H., ROSNER, B. A., & Speizer, F. E. (1995) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199511000-00017 · Cited by 70 · see citing works
Li, S., Yan, X., B�langer, A., & Labrie, F. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00665681 · Cited by 70 · see citing works
Self-citationClinical, Biochemical, Radiographic, Epidemiologic, and Economic Features of Osteoporosis
Johnston, C. C., & Epstein, S. (1981) · Orthopedic Clinics of North America · doi:10.1016/s0030-5898(20)31371-7 · Cited by 66 · see citing works
Absorption and Metabolic Effects of Different Types of Estrogens and Progestogens
Løbo, R. A. (1987) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(21)00577-5 · Cited by 58 · see citing works
Sherwin, B. B., & Gelfand, M. M. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90746-4 · Cited by 55 · see citing works
Dupont, A., Dupont, P., Cusan, L., Tremblay, M., Rioux, J., Cloutier, D., Mailloux, J. R., Lignieres, B. D., Gutkowska, J., Boucher, H., et al. (1991) · Maturitas · doi:10.1016/0378-5122(91)90238-l · Cited by 50 · see citing works
Self-citationObesity in the dog: role of the adrenal steroid dehydroepiandrosterone (DHEA).
MacEwen, E. G., & Kurzman, I. D. (1991) · The Journal of Nutrition · doi:10.1093/jn/121.suppl_11.s51 · Cited by 49 · see citing works
Stahl, F., Schnorr, D., Pilz, C., & Dörner, G. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211136 · Cited by 47 · see citing works
Postmenopausal estrogen and androgen replacement and lipoprotein lipid concentrations
Sherwin, B. B., Gelfand, M. M., Schucher, R., & Gabor, J. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(87)90295-x · Cited by 44 · see citing works
What do we know and what don't we know about tamoxifen in the human uterus
Friedl, A., & Jordan, V. C. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00689674 · Cited by 44 · see citing works
THE DISTRIBUTION OF HYDROXYSTEROID DEHYDROGENASE IN HUMAN SEBACEOUS GLANDS.
Baillie, A. H., THOMSON, J., & MILNE, J. A. (1966) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1966.tb12248.x · Cited by 38 · see citing works
Labrie, F., Simard, J., Luu-The, V., Bèlanger, A., Pelletier, G., Morel, Y., Mébarki, F., Sánchez, R., Durocher, F., Turgeon, C., et al. (1996) · Springer eBooks · doi:10.1007/978-3-662-03230-5_10 · Cited by 34 · see citing works
Self-citationRasmussen, K. R., Arrowood, M. J., & Healey, M. C. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.1.220 · Cited by 33 · see citing works
Need, A. G. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.1.57 · Cited by 29 · see citing works
Direct action of androgen on hot flushes in the human male
DEFAZIO, J., Meldrum, D. R., Winer, J. H., & Judd, H. L. (1984) · Maturitas · doi:10.1016/0378-5122(84)90060-4 · Cited by 23 · see citing works
Chen, C., Bèlanger, A., & Labrie, F. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612511 · Cited by 11 · see citing works
Self-citationEffect of combined implants of oestradiol and testosterone on libido in postmenopausal women
Appleby, L., & Montgomery, J. (1987) · BMJ · doi:10.1136/bmj.294.6584.1417-c · Cited by 8 · see citing works
Chen, C., Li, X., Singh, S. K., Bèlanger, A., & Labrie, F. (1996) · Endocrine Related Cancer · doi:10.1677/erc.0.0030217 · Cited by 6 · see citing works
Self-citationTikkanen, M. J., Nikkilä, E. A., & Vartiainen, E. (1979) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-197902000-00021 · Cited by 3 · see citing works
Weinstein, L., Bewtra, C., & Gallagher, J. C. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90651-k · Cited by 2 · see citing works
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Knop, E., Knop, N., Millar, T., Obata, H., & Sullivan, D. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6997c · Cited by 1,079 · see citing works
Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.11.002 · Cited by 769 · see citing works
Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency
Arlt, W., Callies, F., van Vlijmen, J. C., Koehler, I., Reincke, M., Bidlingmaier, M., Huebler, D., Oettel, M., Ernst, M., Schulte, H. M., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909303411401 · Cited by 644 · see citing works
DHEA in elderly women and DHEA or testosterone in elderly men.
Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054629 · Cited by 566 · see citing works
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
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Labrie, F., Luu-The, V., Bèlanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06264 · Cited by 454 · see citing works
Self-citationBachmann, G., Bancroft, J., Braunstein, G., Burger, H., Davis, S., Dennerstein, L., Goldstein, I., Guay, A., Leiblum, S., Lobo, R., et al. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02969-2 · Cited by 444 · see citing works
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Sullivan, D. A., Rocha, E. M., Aragona, P., Clayton, J. A., Ding, J., Golebiowski, B., Hampel, U., McDermott, A. M., Schaumberg, D. A., Srinivasan, S., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.04.001 · Cited by 451 · see citing works
Hunt, P. J., Gurnell, E. M., Huppert, F. A., Richards, C., Prevost, A. T., Wass, J. A. H., Herbert, J., & Chatterjee, V. K. K. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7022 · Cited by 386 · see citing works
Labrie, F., Luu-The, V., Labrie, C., & Simard, J. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0216 · Cited by 366 · see citing works
Self-citationLabrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L., Gomez, J.-L., & Candas, B. (1998) · Steroids · doi:10.1016/s0039-128x(98)00007-5 · Cited by 347 · see citing works
Self-citationLabrie, F., Archer, D. F., Koltun, W. D., Vachon, A., Young, D. G., Frenette, L., Portman, D. J., Montesino, M., Côté, I., Parent, J., et al. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000571 · Cited by 247 · see citing works
Self-citationGordon, C. M., Grace, E., Emans, S. J., Feldman, H. A., Goodman, E., Becker, K. A., Rosen, C. J., Gundberg, C. M., & LeBoff, M. S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020545 · Cited by 235 · see citing works
Dehydroepiandrosterone (DHEA)—A Precursor Steroid or an Active Hormone in Human Physiology (CME)
Traish, A. M., Kang, H. P., Saad, F., & Guay, A. T. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02523.x · Cited by 237 · see citing works
Alternative and complementary therapies for the menopause
Borrelli, F., & Ernst, E. K. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.05.010 · Cited by 222 · see citing works
Labrie, F., Archer, D., Bouchard, C., Fortier, M., Cusan, L., Gomez, J., Girard, G., Baron, M., Ayotte, N., Moreau, M., et al. (2009) · Menopause · doi:10.1097/gme.0b013e31819e85c6 · Cited by 192 · see citing works
Self-citationLong-Term DHEA Replacement in Primary Adrenal Insufficiency: A Randomized, Controlled Trial
Gurnell, E. M., Hunt, P. J., Curran, S. E., Conway, C. L., Pullenayegum, E. M., Huppert, F. A., Compston, J. E., Herbert, J., & Chatterjee, V. K. K. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1134 · Cited by 189 · see citing works
Labrie, F., Archer, D. F., Bouchard, C., Fortier, M. P., Cusan, L., Gomez, J., Girard, G., Baron, M., Ayotte, N. J., Moreau, M., et al. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31819e8e2d · Cited by 189 · see citing works
Self-citationDHEA, Important Source of Sex Steroids in Men and Even More in Women
Labrie, F. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)82004-7 · Cited by 183 · see citing works
Self-citationTestosterone influences libido and well being in women
Davis, S. R., & Tran, J. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00333-7 · Cited by 184 · see citing works
Johannsson, G., Burman, P., Wirén, L., Engström, B. E., Nilsson, A. G., Ottosson, M., Jonsson, B., Bengtsson, B.-Å., & Karlsson, F. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8494 · Cited by 175 · see citing works
Casson, P. R., Santoro, N. F., Elkind-Hirsch, K. E., Carson, S. A., Hornsby, P. J., Abraham, G. E., & Buster, J. E. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00121-6 · Cited by 174 · see citing works
Effects of DHEA replacement on bone mineral density and body composition in elderly women and men
Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01131.x · Cited by 169 · see citing works
The association of testosterone, sleep, and sexual function in men and women
Andersen, M. L., Alvarenga, T. A., Mazaro‐Costa, R., Hachul, H., & Tufik, S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.060 · Cited by 156 · see citing works
DHEA treatment: myth or reality?
Allolio, B., & Arlt, W. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00617-3 · Cited by 153 · see citing works
Stress Hormone-Related Psychopathology: Pathophysiological and Treatment Implications
Wolkowitz, O. M., Epel, E. S., & Reus, V. I. (2001) · The World Journal of Biological Psychiatry · doi:10.3109/15622970109026799 · Cited by 149 · see citing works
van Vollenhoven, R. F., Park, J. L., Genovese, M. C., West, J. P., & McGuire, J. L. (1999) · Lupus · doi:10.1191/096120399678847588 · Cited by 144 · see citing works
Effect of Smoking on Breast Cancer in Carriers of Mutant BRCA1 or BRCA2 Genes
Brunet, J., Ghadirian, P., Rebbeck, T. R., Lerman, C., Garber, J. E., Tonin, P. N., Abrahamson, J., Foulkes, W. D., Daly, M., Costalas, J. W., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.10.761 · Cited by 141 · see citing works
Arlt, W., Callies, F., Koehler, I., van Vlijmen, J. C., Faßnacht, M., Strasburger, C. J., Seibel, M. J., Huebler, D., Ernst, M. E., Oettel, M., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7974 · Cited by 139 · see citing works
Androgens in Postmenopausal Women: Production, Possible Role, and Replacement Options
Lobo, R. A. (2001) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200106000-00022 · Cited by 141 · see citing works
DHEA Replacement for Postmenopausal Women
Davis, S. R., Panjari, M., & Stanczyk, F. Z. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2888 · Cited by 139 · see citing works
Androgen effects on bone metabolism: recent progress and controversies
Hofbauer, L. C., & Khosla, S. (1999) · European Journal of Endocrinology · doi:10.1530/eje.0.1400271 · Cited by 135 · see citing works
Tearful Relationships? Sex, Hormones, the Lacrimal Gland, and Aqueous-Deficient Dry Eye
Sullivan, D. A. (2004) · The Ocular Surface · doi:10.1016/s1542-0124(12)70147-7 · Cited by 132 · see citing works
Labrie, F., Luu-The, V., Labrie, C., Pelletier, G., & El-Alfy, M. (2000) · Hormone Research in Paediatrics · doi:10.1159/000053264 · Cited by 128 · see citing works
Self-citationEndogenous Anabolic Hormone Responses to Endurance Versus Resistance Exercise and Training in Women
Consitt, L. A., Copeland, J. L., & Tremblay, M. S. (2002) · Sports Medicine · doi:10.2165/00007256-200232010-00001 · Cited by 124 · see citing works
Physiologic regulators of bone turnover in young women with anorexia nervosa
Gordon, C. M., Goodman, E., Emans, S. J., Grace, E., Becker, K. A., Rosen, C. J., Gundberg, C. M., & LeBoff, M. S. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.125003 · Cited by 126 · see citing works
Gordon, C. M., Grace, E., Emans, S. J., Goodman, E., CRAWFORD, M. H., & LeBoff, M. S. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.1.136 · Cited by 123 · see citing works
DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis
Dutheil, F., Vincent, S. D. S., Pereira, B., Schmidt, J., Moustafa, F., Charkhabi, M., Bouillon‐Minois, J., & Clinchamps, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.688367 · Cited by 124 · see citing works
Role of androgens in female genital sexual arousal: receptor expression, structure, and function
Traish, A. M., Kim, N. N., Min, K. S., Munarriz, R. M., & Goldstein, I. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)02978-3 · Cited by 121 · see citing works
Samaras, N., Samaras, D., Frangos, E., Forster, A., & Philippe, J. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1425 · Cited by 120 · see citing works
Labrie, F., Cusan, L., Gomez, J. L., Martel, C., Bérubé, R., Bélanger, P., Bélanger, A., Vandenput, L., Mellström, D., & Ohlsson, C. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.11.004 · Cited by 115 · see citing works
Self-citationLabrie, F., Archer, D. F., Koltun, W. D., Vachon, A., Young, D. G., Frenette, L., Portman, D. J., Montesino, M., Côté, I., Parent, J., et al. (2018) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001238 · Cited by 117 · see citing works
Self-citationAre women with Sjögren's syndrome androgen-deficient?
Sullivan, D. A., Bélanger, A., Cermak, J. M., Bérubé, R., Papas, A., Sullivan, R. M., Yamagami, H., Dana, M. R., & Labrie, F. (2003) · PubMed · Cited by 108 · see citing works
Self-citationJankowski, C. M., Gozansky, W. S., Schwartz, R. S., Dahl, D. J., Kittelson, J. M., Scott, S., Pelt, R. E. V., & Kohrt, W. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2484 · Cited by 109 · see citing works
Dehydroepiandrosterone and ageing.
Arlt, W. (2004) · Best practice & research. Clinical endocrinology & metabolism · doi:10.1016/j.beem.2004.02.006 · Cited by 121 · see citing works
Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing?s syndrome
Minetto, M. A., Reimondo, G., Osella, G., Ventura, M., Angeli, A., & Terzolo, M. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1616-3 · Cited by 108 · see citing works
Hartkamp, A., Geenen, R., Godaert, G. L. R., Bootsma, H., Kruize, A. A., Bijlsma, J. W. J., & Derksen, R. H. W. M. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.071563 · Cited by 104 · see citing works
Dehydroepiandrosterone sulfate and longevity: New clues for an old friend
Yen, S. S. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161278698 · Cited by 102 · see citing works
Kistner's Gynecology and Women's Health
Ryan, K. J. (1999) · Cited by 104 · see citing works
Serum steroid levels during 12-week intravaginal dehydroepiandrosterone administration
Labrie, F., Archer, D. F., Bouchard, C., Fortier, M. P., Cusan, L., Gomez, J., Girard, G., Baron, M., Ayotte, N. J., Moreau, M., et al. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31819e8930 · Cited by 101 · see citing works
Self-citationvon Mühlen, D. V., Laughlin, G., Kritz-Silverstein, D., Bergstrom, J., & Bettencourt, R. (2008) · Osteoporosis International · doi:10.1007/s00198-007-0520-z · Cited by 98 · see citing works
Aizawa, K., Iemitsu, M., Maeda, S., Jesmin, S., Otsuki, T., Mowa, C. N., Miyauchi, T., & Mesaki, N. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00367.2006 · Cited by 95 · see citing works
Androgens and Women at the Menopause and Beyond
Morley, J. E., & Perry, H. M. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.5.m409 · Cited by 98 · see citing works
Effect of intravaginal DHEA on serum DHEA and eleven of its metabolites in postmenopausal women
Labrie, F., Cusan, L., Gomez, J. L., Côté, I., Bérubé, R., Bélanger, P., Martel, C., & Labrie, C. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.06.003 · Cited by 98 · see citing works
Self-citationHormone replacement therapy: current controversies
Davison, S. L., & Davis, S. R. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01774.x · Cited by 94 · see citing works
Portman, D. J., Labrie, F., Archer, D. F., Bouchard, C., Cusan, L., Girard, G., Ayotte, N. J., Koltun, W. D., Blouin, F., Young, D. G., et al. (2015) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000470 · Cited by 93 · see citing works
Self-citationDHEA for postmenopausal women: A review of the evidence
Panjari, M., & Davis, S. R. (2010) · Maturitas · doi:10.1016/j.maturitas.2009.12.017 · Cited by 91 · see citing works
Yen, S. S. C., & Laughlin, G. A. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00046-1 · Cited by 92 · see citing works
DiVasta, A. D., Feldman, H. A., Giancaterino, C., Rosen, C. J., LeBoff, M. S., & Gordon, C. M. (2012) · Metabolism · doi:10.1016/j.metabol.2011.11.016 · Cited by 90 · see citing works
Androgen therapy with dehydroepiandrosterone
Buvat, J. (2003) · World Journal of Urology · doi:10.1007/s00345-003-0367-7 · Cited by 87 · see citing works
Intravaginal dehydroepiandrosterone (prasterone), a highly efficient treatment of dyspareunia
Labrie, F., Archer, D. F., Bouchard, C., Fortier, M. P., Cusan, L., Gomez, J.-L., Girard, G., Baron, M., Ayotte, N. J., Moreau, M., et al. (2011) · Climacteric · doi:10.3109/13697137.2010.535226 · Cited by 88 · see citing works
Self-citationSix-month oral dehydroepiandrosterone supplementation in early and late postmenopause
Stomati, M., Monteleone, P., Casarosa, E., Quirici, B., Puccetti, S., Bernardi, F., Genazzani, A. D., Rovati, L., Luisi, M., & Genazzani, A. R. (2000) · Gynecological Endocrinology · doi:10.3109/09513590009167703 · Cited by 86 · see citing works
DHEA and intracrinology at menopause, a positive choice for evolution of the human species
Labrie, F., & Labrie, C. (2012) · Climacteric · doi:10.3109/13697137.2012.733983 · Cited by 82 · see citing works
Self-citationOsteoporosis Is More Prevalent in Adrenal than in Pituitary Cushing's Syndrome.
OHMORI, N., NOMURA, K., OHMORI, K., KATO, Y., ITOH, T., & TAKANO, K. (2003) · Endocrine Journal · doi:10.1507/endocrj.50.1 · Cited by 81 · see citing works
Off-label use of hormones as an antiaging strategy: a review
Samaras, N., Papadopoulou, M.-A., Samaras, D., & Ongaro, F. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s48918 · Cited by 81 · see citing works
Modulation of Collagen Metabolism by the Topical Application of Dehydroepiandrosterone to Human Skin
Shin, M. H., Rhie, G., Park, C., Kim, K. H., Cho, K. H., Eun, H. C., & Chung, J. H. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23588.x · Cited by 78 · see citing works
Acute Dehydroepiandrosterone (DHEA) Effects on Sexual Arousal in Postmenopausal Women
Hackbert, L., & Heiman, J. R. (2002) · Journal of Women s Health & Gender-Based Medicine · doi:10.1089/152460902753645290 · Cited by 79 · see citing works
Sex steroids in Sjögren’s syndrome
Konttinen, Y. T., Fuellen, G., Bing, Y., Porola, P., Stegaev, V., Trokovic, N., Falk, S. S. I., Liu, Y., Szodoray, P., & Takakubo, Y. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.01.004 · Cited by 78 · see citing works
Mechanism of action of anti-aging DHEA-S and the replacement of DHEA-S
Nawata, H., Yanase, T., Goto, K., Okabe, T., & Ashida, K. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00393-1 · Cited by 77 · see citing works
Gingras, S., Moriggl, R., Groner, B., & Simard, J. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.1.0221 · Cited by 76 · see citing works
Hormonal effects on skin aging
Phillips, T. J., Demirçay, Z., & Sahu, M. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70092-6 · Cited by 74 · see citing works
Martel, C., Labrie, F., Archer, D. F., Ke, Y., Gonthier, R., Simard, J.-N., Lavoie, L., Vaillancourt, M., Montesino, M., Balser, J., et al. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.016 · Cited by 72 · see citing works
Self-citationIdentifying and Treating Sexual Dysfunction in Postmenopausal Women: The Role of Estrogen
Simon, J. A. (2011) · Journal of Women s Health · doi:10.1089/jwh.2010.2151 · Cited by 74 · see citing works
Fatigue in progressive multiple sclerosis is associated with low levels of dehydroepiandrosterone
Téllez, N., Comabella, M., Julià, E., Río, J., Tintoré, M., Brieva, L., Nos, C., & Montalbán, X. (2006) · Multiple Sclerosis Journal · doi:10.1191/135248505ms1322oa · Cited by 71 · see citing works
Tagawa, N., Tamanaka, J., Fujinami, A., Kobayashi, Y., Takano, T., Fukata, S., Kuma, K., Tada, H., & Amino, N. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.4.523 · Cited by 70 · see citing works
Dehydroepiandrosterone: Is There a Role for Replacement?
Dhatariya, K., & Nair, K. S. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.10.1257 · Cited by 71 · see citing works
Might DHEA be Considered a Beneficial Replacement Therapy in the Elderly?
Genazzani, A. D., Lanzoni, C., & Genazzani, A. R. (2007) · Drugs & Aging · doi:10.2165/00002512-200724030-00001 · Cited by 69 · see citing works
Androgen insufficiency in women: diagnostic and therapeutic implications
Rivera‐Woll, L., Papalia, M.-A., Davis, S. R., & Burger, H. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh037 · Cited by 66 · see citing works
Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone
Weiss, E. P., Shah, K. N., Fontana, L., Lambert, C. P., Holloszy, J. O., & Villareal, D. T. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27265 · Cited by 66 · see citing works
Straub, R. H., Lehle, K., Herfarth, H. H., Weber, M., Falk, W., Preuner, J. G., & Schölmerich, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460365 · Cited by 67 · see citing works
Uses of DHEA in aging and other disease states
JOHNSON, M., Bebb, R. A., & Sirrs, S. M. (2002) · Ageing Research Reviews · doi:10.1016/s0047-6374(01)00369-4 · Cited by 66 · see citing works
Schirra, F., Suzuki, T., Dickinson, D. P., Townsend, D. J., Gipson, I. K., & Sullivan, D. A. (2006) · Cornea · doi:10.1097/01.ico.0000183664.80004.44 · Cited by 65 · see citing works
Vaginal DHEA to treat menopause related atrophy: A review of the evidence
Panjari, M., & Davis, S. R. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.06.005 · Cited by 65 · see citing works
Aromatase in bone: roles of Vitamin D3 and androgens
Yanase, T., Suzuki, S., Goto, K., Nomura, M., Okabe, T., Takayanagi, R., & Nawata, H. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00349-2 · Cited by 65 · see citing works
ADRENAL AND GONADAL STEROIDS INHIBIT IL-6 SECRETION BY HUMAN MARROW CELLS
Gordon, C. M., LeBoff, M. S., & Glowacki, J. (2001) · Cytokine · doi:10.1006/cyto.2001.0962 · Cited by 64 · see citing works
Does Hormone Replacement Normalize Bone Geometry in Adolescents With Anorexia Nervosa?
DiVasta, A. D., Feldman, H. A., Beck, T., LeBoff, M. S., & Gordon, C. M. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2005 · Cited by 63 · see citing works
Berger, L., Elalfy, M., Martel, C., & Labrie, F. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.02.018 · Cited by 62 · see citing works
Self-citationDehydroepiandrosterone for women in the peri- or postmenopausal phase
Scheffers, C. S., Armstrong, S., Cantineau, A. E., Farquhar, C. M., & Jordan, V. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011066.pub2 · Cited by 61 · see citing works
Yeung, T. W. Y., Li, R., Lee, V. C. Y., Ho, P. C., & Ng, E. H. Y. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3071 · Cited by 60 · see citing works
Oral dehydroepiandrosterone (DHEA) replacement therapy in women with Addison's disease
Gebre‐Medhin, G., Husebye, E. S., Mallmin, H., Helström, L., Berne, C., Karlsson, F. A., & Kämpe, O. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01017.x · Cited by 59 · see citing works
The safety of 52 weeks of oral DHEA therapy for postmenopausal women
Panjari, M., Bell, R. J., Jane, F., Adams, J., Morrow, C., & Davis, S. R. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.03.020 · Cited by 57 · see citing works
DHEA deficiency syndrome: a new term for old age?
Hinson, J., & Raven, P. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1630001 · Cited by 56 · see citing works
Dehydroepiandrosterone for the treatment of systemic lupus erythematosus
van Vollenhoven, R. (2002) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.3.1.23 · Cited by 54 · see citing works
Pharmacology And Therapeutic Effects of Dehydroepiandrosterone In Older Subjects
Legrain, S., & Girard, L. (2003) · Drugs & Aging · doi:10.2165/00002512-200320130-00001 · Cited by 54 · see citing works
Bouchard, C., Labrie, F., Derogatis, L. R., Girard, G., Ayotte, N. J., Gallagher, J. C., Cusan, L., Archer, D. F., Portman, D. J., Lavoie, L., et al. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0044 · Cited by 54 · see citing works
Self-citationDrug Insight: breast cancer prevention and tissue-targeted hormone replacement therapy
Labrie, F. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0559 · Cited by 52 · see citing works
Self-citationWang, L., Wang, Y., Wang, W., Zhu, Y., & Li, D. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.02173 · Cited by 52 · see citing works
Coles, A. J., Thompson, S. A. J., Cox, A., Curran, S., Gurnell, E. M., & Chatterjee, V. K. (2005) · European Journal of Immunology · doi:10.1002/eji.200526128 · Cited by 51 · see citing works
Dehydroepiandrosterone replacement therapy.
Gurnell, E. M., & Chatterjee, V. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450103 · Cited by 78 · see citing works
Endometrium and steroids, a pathologic overview
Plaza-Parrochia, F., Romero, C., Valladares, L., & Vega, M. (2017) · Steroids · doi:10.1016/j.steroids.2017.08.007 · Cited by 49 · see citing works
- Authors
- Labrie, F., Diamond, P., Cusan, L., Gomez, J.-L., Bélanger, A., & Candas, B.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Corresponding author
- Labrie, Fernand
- ORCID
- Candas, Bernard
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-10
- Volume
- 82
- Issue
- 10
- Pages
- 3498-3505
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1970025509
- Cited by
- 292
- References
- 71
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 10
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- dehydroepiandrosterone, DHEA replacement therapy, postmenopausal women, bone mineral density, endometrial atrophy, osteocalcin, bone-specific alkaline phosphatase, urinary hydroxyproline, osteoporosis prevention, androgenic effects, estrogenic effects
- MeSH terms
- Aged, Atrophy, Bone and Bones, Bone Resorption, Dehydroepiandrosterone, Endometrium, Female, Humans, Middle Aged, Osteogenesis, Sebum, Sex Hormone-Binding Globulin, Vagina, Biomarkers, Bone Density, Bone Remodeling, Postmenopause
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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