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Cited by 11Hypothalamic control of reproductive hormonesPituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

α-Subunit and Gonadotropin Responses to Luteinizing Hormone-Releasing Hormone in Hyperprolactinemic Women before and after Bromocriptine*

Klibanski, Anne, Beitins, Inese Z., Zervas, Nicholas T., McArthur, Janet W., Ridgway, E. Chester·1983·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-56-4-774
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Abstract

alpha-Subunit and gonadotropin responses to a LHRH infusion (0.2 micrograms/min) for 4 h were studied in eight hyperprolactinemic amenorrheic women, ages 23-40, and in five normal women in the early follicular phase of the menstrual cycle. Basal alpha-subunit and LH concentrations were comparable to normal women; however, basal FSH concentrations were significantly (P less than 0.05) lower. Peak serum alpha, LH, and FSH concentrations during the LHRH infusion were significantly higher than controls (P less than 0.01, P less than 0.05, and P less than 0.01, respectively). Gel chromatography of serum confirmed the presence of both free alpha-subunit and intact LH which had normal biological activity. Six of the women were restudied in the early follicular phase of the cycle after return of normal ovulatory function and normalization of serum PRL concentrations. During bromocriptine therapy, peak serum alpha, LH, and FSH concentrations decreased significantly (P less than 0.02, P less than 0.05, and P less than 0.001, respectively) and were comparable to control subjects. The changes in serum alpha and gonadotropin responses to the LHRH infusion during bromocriptine therapy occurred independently of the serum estradiol concentrations. Abnormalities in the regulation of alpha-subunit and gonadotropin secretion are present in hyperprolactinemia. These abnormalities reverse with bromocriptine therapy and may occur independently of changes in gonadal steroids.

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Crossref · 10.1210/jcem-56-4-774

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25 of 25 references verified0 citation errors · 0 not checkable

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  • Hyperprolactinemia inhibits the pulsatile release of GnRH, which in turn inhibits the release of both LH and FSH from the pituitary.

    “Hyperprolactinemia inhibits the pulsatile release of gonadotropin-releasing hormone (GnRH), which in turn inhibits the release of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary (5-10).”

    From Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans (2022) · cites this paper as [10]

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Authors
Klibanski, A., Beitins, I. Z., Zervas, N. T., McArthur, J. W., & Ridgway, E. C.
Affiliations
Massachusetts General Hospital (US)
ORCID
Klibanski, Anne
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1983-04
Volume
56
Issue
4
Pages
774-780
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-56-4-774
OpenAlex
W2083070474
Cited by
11
References
25
Citations by year
2022: 1 · 2019: 1 · 2013: 1
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
hyperprolactinemia, gonadotropin-releasing hormone, gonadotropin secretion, follicle-stimulating hormone, bromocriptine, amenorrhea, prolactin, gonadotropin regulation, estradiol
MeSH terms
Adult, Amenorrhea, Bromocriptine, Chromatography, Gel, Female, Follicle Stimulating Hormone, Glycoproteins, Gonadotropins, Pituitary, Humans, Kinetics, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Peptide Fragments, Prolactin, Glycoprotein Hormones, alpha Subunit

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