The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Dynamics of serum thyrotropin and thyroid hormone changes in fasting
Abstract
This study was designed to address the question of whether decreased hypothalamic TRH secretion was responsible for the transient decline in serum TSH levels characteristic of the early phase of fasting in man. Changes in serum TSH, total T4 (TT4), free T4 (FT4), and total T3 (TT3)/TT4 and total rT3(TrT3)/TT4 ratio values together with plasma TRH levels were evaluated before, during, and after a constant 48-h infusion of either TRH (75 ng/min), or saline, initiated at 10 h into a 6-day fast, in groups of six ambulating, mildly obese female subjects. On the first day of the fast, no change in serum TSH levels was seen with saline infusion relative to control, whereas mean TSH levels rose 2 1/2-fold with TRH infusion. On the second day of the fast, serum TSH levels simultaneously declined in both the saline- (43%, P less than 0.005) and TRH- (52%, P less than 0.005)-infused groups relative to the previous day. On the third day of the fast, after stopping the infusions, mean serum TSH levels fell below control in both the saline- and TRH-treated groups, but subsequently returned to prefasting levels. A distinct circadian pattern of TSH release was present throughout the study. Plasma TRH values were unaffected by fasting in the saline-infused group, but rose 2 1/2-fold in the TRH-infused group. The sequence of changes in the serum thyroid hormone indices were similar for the two groups: a rapid rise in FT4 was followed by a gradual fall in TT3/TT4 ratios during the first 24 h of fast, which was followed by a rise in TrT3/TT4 ratios after 48 h of fast. This study in fasting, mildly obese females suggests that: 1) The transient suppression of serum TSH during early fasting is not TRH mediated. 2) Fasting does not alter plasma TRH levels. 3) A temporal sequence of changes in serum thyroid hormone indices occurs in fasting, this being an initial rise in FT4 (10 h) followed by a fall in both serum TT3/TT4 (12-14 h) and TSH (30-36 h) and finally by a rise in TrT3/TT4 levels (48 h). This sequence of events suggests that the initial inhibition of serum TSH levels in early fasting results from the acute elevation in FT4 levels, and that the reestablishment of normal serum TSH levels with continued fasting is associated with declining serum TT3 levels.
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In the citing paper
“A complex sequence of alterations in serum TSH and thyroid hormone levels has been observed in humans undergoing a short-term fast (37, 38).”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [37]
In the citing paper
“Free T4 levels may be transiently increased or normal, while TSH levels may be normal or decreased (12, 13).”
From Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism? (2019) · cites this paper as [12]
In the citing paper
“A simultaneous increase in rT3 occurs in the first 2 weeks after caloric restriction, followed by normalization.”
From Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism? (2019) · cites this paper as [12]
In the citing paper
“During fasting or relative caloric deprivation, for instance, serum T3 is decreased as a homeostatic response to conserve energy and protein.”
From Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism? (2019) · cites this paper as [12]
Citations
Cites
Fasting, Feeding and Regulation of the Sympathetic Nervous System
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Effect of dietary composition on fasting-induced changes in serum thyroid hormones and thyrotropin
Azizi, F. (1978) · Metabolism · doi:10.1016/0026-0495(78)90137-3 · Cited by 156
Palmblad, J. E. W., Levi, L. D., Burger, A., Melander, A., Westgren, U., von Schenck, H., & Skude, G. (1977) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1977.tb15648.x · Cited by 153
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Free Thyroxine Estimates in Nonthyroidal Illness: Comparison of Eight Methods *
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Valensi, P. E., Attali, J. R., Darnis, D., & Sebaoun, J. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5260-0_54
Impaired TSH Secretion during Sustained Hyperglucagonemia in Anesthetized Dogs
Kabadi, U. M., & FRAGSTEDT, L. (1995) · Thyroid · doi:10.1089/thy.1995.5.389
Metabolism in Response to Propylthiouracil, Dexamethasone, and Thyroxine Administration in Man
LoPresti, J. S., Eigen, A., Kaptein, E. M., Anderson, K. P., Spencer, C. A., & Nicoloff, J. T. (1989)
Self-citationAtwood, E. M. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0105190
Triiodothyronine in Cultured Rat Anterior Pituitary Cells and Their Effects on Thyrotropin Secretion
Everts, M. E., Visser, T. J., Moerings, E. P. C. M., Tempelaars, A. M., van Toor, H., Docter, R., de Jong, M., Krenning, E. P., HENNEMANN, G., & Netherlands, T. (1995)
CARMEN ROSA MORALES GARCÍA Estudio clínico y evolutivo de la anorexia nerviosa
Tecnologías, C. Y. (1996)
Endocrine Testing in Acute and Critical Illness
Morovat, R. (2018) · Wiley eBooks · doi:10.1002/9781119374800.ch2
The Thyroid Hormone Axis: Its Roles in Body Weight Regulation, Obesity, and Weight Loss
Vella, K. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_10
Sadoughi, B. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10248
STUDY OF IMPACT OF BIRTH ASPHYXIA ON THYROID HORMONE IN NEWBORN.
Pradhan, S., Mahar, J., Hembram, G., & Mishra, P. (2023) · Student s Journal of Health Research Africa · doi:10.51168/sjhrafrica.v4i12.871
Metadata
- Authors
- Spencer, C. A., Lum, S. M. C., Wilber, J. F., Kaptein, E. M., & Nicoloff, J. T.
- Affiliations
- University of Southern California (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1983-05
- Volume
- 56
- Issue
- 5
- Pages
- 883-888
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2081853649
- Cited by
- 111
- References
- 31
- Citations by year
- 2024: 1 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- fasting, thyroid-stimulating hormone, thyrotropin-releasing hormone, thyroid hormones, free thyroxine, triiodothyronine, reverse T3, hypothalamic-pituitary-thyroid axis, circadian rhythm, obesity, women
- MeSH terms
- Adult, Circadian Rhythm, Fasting, Female, Humans, Kinetics, Middle Aged, Thyroid Hormones, Thyrotropin, Thyrotropin-Releasing Hormone, Thyroxine, Triiodothyronine, Triiodothyronine, Reverse
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