Pituitary nuclear 3,5,3’-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine
Abstract
An excellent correlation was observed between nuclear triiodothyronine (T 3 ) and the ensuing suppression of thyrotropin (TSH) after a single intravenous injection of T 3 to thyroidectomized (hypothyroid) rats. At 1 and 2 hours after injection of thyroxine (T 4 ), in amounts equally potent to the administered T 3 in terms of acute suppression of TSH, the same quantities of T 3 were found in the pituitary nuclei. Virtually no nuclear T 4 was present, and plasma T 3 was negligible at these short intervals after T 4 injection. These results suggest that suppression of TSH release in hypothyroid rats occurs by interaction of T 3 with the nuclear receptor of the thyrotroph. After T 4 injection, the T 3 found in the nucleus is derived from rapid intrapituitary monodeiodination.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TH homeostasis is maintained globally and locally through multiple mechanisms that coordinately regulate the production, secretion, distribution, and metabolism of THs.
“TH homeostasis is maintained both globally and locally through multiple mechanisms that coordinately regulate the production, secretion, distribution, and metabolism of THs.”
From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [6]
Cites
Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine
Oppenheimer, J. H., Schwartz, H. L., & Surks, M. I. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107063 · Cited by 258 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bianco, A. C., Salvatore, D., Gereben, B., Berry, M. J., & Larsen, P. R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0455 · Cited by 1,853 · see citing works
Deiodinases: implications of the local control of thyroid hormone action
Bianco, A. C., & Kim, B. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29812 · Cited by 845 · see citing works
Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans
Luiza Maia, A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25083 · Cited by 360 · see citing works
Thyroid-Pituitary Interaction: Feedback Regulation of Thyrotropin Secretion by Thyroid Hormones
Bleich, H. L., Moore, M. J., & Larsen, P. R. (1982) · New England Journal of Medicine · doi:10.1056/nejm198201073060107 · Cited by 357 · see citing works
Self-citationParadigms of dynamic control of thyroid hormone signaling
Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M. L. C. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00275 · Cited by 293 · see citing works
Escobar-Morreale, H. F., Obregón, M. J., Escobar del Rey, F., & Morreale de Escobar, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118353 · Cited by 287 · see citing works
Molecular biological and biochemical characterization of the human type 2 selenodeiodinase.
Salvatore, D., Bartha, T., Harney, J. W., & Larsen, P. R. (1996) · Endocrinology · doi:10.1210/endo.137.8.8754756 · Cited by 284 · see citing works
Self-citationGereben, B., Zeöld, A., Dentice, M., Salvatore, D., & Bianco, A. C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7396-0 · Cited by 207 · see citing works
Type 2 iodothyronine deiodinase is highly expressed in human thyroid.
Salvatore, D., Tu, H., Harney, J. W., & Larsen, P. R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118880 · Cited by 196 · see citing works
Self-citationSILVA, J. E., DICK, T. E., & LARSEN, P. R. (1978) · Endocrinology · doi:10.1210/endo-103-4-1196 · Cited by 189 · see citing works
Self-citationDYESS, E. M., SEGERSON, T. P., LIPOSITS, Z., PAULL, W. K., KAPLAN, M. M., WU, P., JACKSON, I. M. D., & LECHAN, R. M. (1988) · Endocrinology · doi:10.1210/endo-123-5-2291 · Cited by 127 · see citing works
Christoffolete, M. A., Ribeiro, R., Singru, P., Fekete, C., da Silva, W. S., Gordon, D. F., Huang, S. A., Crescenzi, A., Harney, J. W., Ridgway, E. C., et al. (2006) · Endocrinology · doi:10.1210/en.2005-1300 · Cited by 118 · see citing works
Self-citationDynamics of serum thyrotropin and thyroid hormone changes in fasting
Spencer, C. A., Lum, S. M. C., Wilber, J. F., Kaptein, E. M., & Nicoloff, J. T. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-5-883 · Cited by 111 · see citing works
Kakucska, I., Rand, W., & Lechan, R. M. (1992) · Endocrinology · doi:10.1210/endo.130.5.1572297 · Cited by 113 · see citing works
Reawakened interest in type III iodothyronine deiodinase in critical illness and injury
Huang, S. A., & Bianco, A. C. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0727 · Cited by 95 · see citing works
Torlontano, M., Durante, C., Torrente, I., Crocetti, U., Augello, G., Ronga, G., Montesano, T., Travascio, L., Verrienti, A., Bruno, R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1067 · Cited by 92 · see citing works
Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism
Chao, M., Jiawei, X., Xia, H., Guoming, W., Yangang, W., Xufu, W., & Shuyao, Z. (2009) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e32832c79e0 · Cited by 93 · see citing works
Coppola, A., Meli, R., & Diano, S. (2005) · Endocrinology · doi:10.1210/en.2004-1361 · Cited by 81 · see citing works
Treatment for congenital hypothyroidism: thyroxine alone or thyroxine plus triiodothyronine?
Cassio, A., Cacciari, E., Cicognani, A., Damiani, G., Missiroli, G., Corbelli, E., Balsamo, A., Bal, M., & Gualandi, S. (2003) · PEDIATRICS · doi:10.1542/peds.111.5.1055 · Cited by 71 · see citing works
Eisenberg, M., Samuels, M., & DiStefano, J. J. (2008) · Thyroid · doi:10.1089/thy.2007.0388 · Cited by 65 · see citing works
Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion
Jing, L., & Zhang, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992883 · Cited by 61 · see citing works
Altered thyroid hormone levels in bacterial sepsis: The role of nutritional adequacy
Richmand, D. A., Molitch, M. E., & O'Donnell, T. F. (1980) · Metabolism · doi:10.1016/0026-0495(80)90036-0 · Cited by 44 · see citing works
DUSSAULT, J. H., COULOMBE, P., & WALKER, P. (1982) · Endocrinology · doi:10.1210/endo-110-3-1037 · Cited by 40 · see citing works
- Authors
- Silva, J. E., & Larsen, P. R.
- Affiliations
- Thyroid Unit, Peter Bent Brigham Hospital, Boston, Massachusetts 02115
- Venue
- Science
- Published
- 1977-11-11
- Volume
- 198
- Issue
- 4317
- Pages
- 617-620
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038357159
- Cited by
- 198
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- triiodothyronine, thyroxine, thyrotropin secretion, thyrotrophs, nuclear receptors, TSH suppression, hypothyroidism, thyroidectomy, thyroid hormone action
- MeSH terms
- Animals, Cell Nucleus, Male, Pituitary Gland, Anterior, Receptors, Cell Surface, Thyroidectomy, Thyrotropin, Thyroxine, Triiodothyronine, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
