The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Progesterone Modulation of Pulsatile Luteinizing Hormone Secretion in Normal Women*
Abstract
Recent studies show that the frequency and amplitude of pulsatile LH secretion change during the normal human menstrual cycle; however, the neuroendocrine mechanisms underlying these changes are poorly understood. To assess the role of progesterone (P) in regulating LH secretion patterns, we treated normal women (n = 5) with im P in oil during the follicular phase of their cycle and compared LH pulse frequency, amplitude, and mean plasma level during treatment to those in normal cycling women. Normal women were studied five times in five menstrual cycles. Each study lasted 24 h, with a sampling interval of 20 min. The cycle phases studied were early follicular (twice), late follicular (LF), midluteal, and LF with P therapy to simulate luteal phase plasma P levels. LH pulse frequency was slower (P less than or equal to 0.001) in the midluteal phase than in either the early follicular phase or LF, and furthermore, P, administered in the normal follicular phase, slowed LH pulse frequency, augmented pulse amplitude, and reduced mean plasma LH levels compared to those in untreated women studied at the same cycle phase (P less than or equal to 0.02). We infer that P secretion by the ovary mediates the change in the LH secretory pattern during the luteal phase of the normal menstrual cycle, and that at least part of this effect is mediated by the central nervous system.
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“Normal women have been shown to have reproducible and stable LH pulse frequencies in the early follicular phase of the menstrual cycle [32] when frequent sampling (every 10 min) is performed [33].”
From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [32]
Citations
Cites
The Neuroendocrine Control of the Menstrual Cycle
Knobil, E. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-571136-4.50008-5 · Cited by 1,285
Clarke, I. J., & Cummins, J. T. (1982) · Endocrinology · doi:10.1210/endo-111-5-1737 · Cited by 921
Radioimmunoassay: A Method for Human Chorionic Gonadotropin and Human Luteinizing Hormone1
MIDGLEY, A. R. (1966) · Endocrinology · doi:10.1210/endo-79-1-10 · Cited by 760
Wildt, L., Häusler, A., Marshall, G. R., HUTCHISON, J. S., Plant, T. M., Belchetz, P. E., & Knobil, E. (1981) · Endocrinology · doi:10.1210/endo-109-2-376 · Cited by 678
Pulsatile Patterns of Gonadotropin Release in Subjects with and without Ovarian Function
Yen, S. S. C., TSAI, C. C., Naftolin, F. N., VANDENBERG, G., & Ajabor, L. N. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-4-671 · Cited by 459
LEVINE, J. E., PAU, K.-Y. F., RAMIREZ, V. D., & JACKSON, G. L. (1982) · Endocrinology · doi:10.1210/endo-111-5-1449 · Cited by 384
Damme, M. ‐. V., Robertson, D. M., & Diczfalusy, E. R. (1974) · European Journal of Endocrinology · doi:10.1530/acta.0.0770655 · Cited by 378
THE ROLE OF ENDOGENOUS OPIATES ON LH SECRETION DURING THE MENSTRUAL CYCLE
QUIGLEY, M. E., & Yen, S. S. C. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-1-179 · Cited by 355
Circhoral Oscillations of Plasma LH Levels in the Ovariectomized Rhesus Monkey 1 , 2
Dierschke, D. J., Bhattacharya, A. N., Atkinson, L. E., & Knobil, E. (1970) · Endocrinology · doi:10.1210/endo-87-5-850 · Cited by 343
Endogenous Opiates Modulate Pulsatile Luteinizing Hormone Release in Humans*
ROPERT, J. F., QUIGLEY, M. E., & Yen, S. S. C. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-3-583 · Cited by 228
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Molecular Biology of the Pituitary Gonadotropins
GHARIB, S. D., Wierman, M. E., Shupnik, M. A., & Chin, W. W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-1-177 · Cited by 697
Kuang, Y., Chen, Q., Fu, Y., Wang, Y., Hong, Q., Lyu, Q., Ai, A., & Shoham, Z. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.03.022 · Cited by 412
Waldstreicher, J., Santoro, N. F., Hall, J. E., Filicori, M., & Crowley, W. F. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-1-165 · Cited by 400
Eagleson, C. A., Gingrich, M. B., Pastor, C. L., Arora, T. K., Solorzano, C. M. B., Evans, W. S., & Marshall, J. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6992 · Cited by 413
The Hypothalamic Control of the Menstrual Cycle and the Role of Endogenous Opioid Peptides
Ferin, M., Vugt, D. V., & Wardlaw, S. L. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-571140-1.50015-3 · Cited by 311
Metadata
- Authors
- SOULES, M. R., STEINER, R. A., CLIFTON, D. K., COHEN, N. L., AKSEL, S., & BREMNER, W. J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1984-02
- Volume
- 58
- Issue
- 2
- Pages
- 378-383
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2127309304
- Cited by
- 319
- References
- 23
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 3 · 2023: 11 · 2022: 13 · 2021: 8 · 2020: 10 · 2019: 13 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 2
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD012629)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- progesterone, luteinizing hormone secretion, pulsatile LH secretion, LH pulse frequency, LH pulse amplitude, menstrual cycle, luteal phase, follicular phase, progesterone therapy, neuroendocrine regulation, hypothalamic-pituitary-gonadal axis
- MeSH terms
- Adult, Estradiol, Female, Follicular Phase, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Menstruation, Progesterone
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