HORMONAL INFLUENCES ON THE SECRETION OF STEROID-BINDING PROTEINS BY A HUMAN HEPATOMA-DERIVED CELL LINE
Abstract
We examined the influence of numerous substances on the secretion of corticosteroid-binding globulin (CBG) and testosterone-estradiol binding globulin (TeBG) by a human hepatoma-derived cell line. Thyroxine, at physiologic concentrations, resulted in an increased secretion of TeBG but not CBG. Estrogens, antiestrogens, and androgens were without effect on either of these binding proteins.
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Biosynthesis of SHBG is mainly situated in hepatocytes and transcriptional control of the SHBG gene is influenced by various factors.
“Biosynthesis of SHBG is mainly situated in hepatocytes and transcriptional control of the SHBG gene is, as discussed in the previous section, influenced by various factors [83, 84].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [83]
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PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693 · see citing works
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ABALOVICH, M., LEVALLE, O., HERMES, R., SCAGLIA, H., ARANDA, C., ZYLBERSZTEIN, C., ONETO, A., AQUILANO, D., & GUTIERREZ, S. (1999) · Thyroid · doi:10.1089/thy.1999.9.857 · Cited by 122 · see citing works
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Narinx, N., David, K., Walravens, J., Vermeersch, P., Claessens, F., Fiers, T., Lapauw, B., Antonio, L., & Vanderschueren, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04562-1 · Cited by 96 · see citing works
DIETARY LIPIDS : AN ADDITIONAL REGULATOR OF PLASMA LEVELS OF SEX HORMONE BINDING GLOBULIN
REED, M. J., CHENG, R. W., SIMMONDS, M., RICHMOND, W., & JAMES, V. H. T. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-5-1083 · Cited by 96 · see citing works
Hamilton‐Fairley, D., Kiddy, D., Anyaoku, V., Koistinen, R., Seppälä, M., & Franks, S. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02378.x · Cited by 75 · see citing works
CODACCIONI, J. L., ORGIAZZI, J., BLANC, P., PUGEAT, M., ROULIER, R., & CARAYON, P. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-4-656 · Cited by 76 · see citing works
Vanbillemont, G., Bogaert, V., De Bacquer, D., Lapauw, B., Goemaere, S., Toye, K., Van Steen, K., Taes, Y., & Kaufman, J. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03365.x · Cited by 46 · see citing works
- Authors
- ROSNER, W., ADEN, D. P., & KHAN, M. S.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- The Wistar Institute (US)
- ORCID
- KHAN, M. SAEED
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1984-10
- Volume
- 59
- Issue
- 4
- Pages
- 806-808
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2079354608
- Cited by
- 115
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 3 · 2017: 1 · 2015: 1 · 2012: 2
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- corticosteroid-binding globulin, testosterone-estradiol-binding globulin, hepatoma cell lines, thyroxine, estrogen, antiestrogens, androgens, hormonal regulation
- MeSH terms
- Animals, Cell Line, Cytosol, Estradiol, Carcinoma, Hepatocellular, Humans, Liver, Liver Neoplasms, Sex Hormone-Binding Globulin, Thyroxine, Transcortin, Rats
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