Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.

PLYMATE, STEPHEN R.; MATEJ, LOUIS A.; JONES, ROBERT E.; FRIEDL, KARL E.

doi:10.1210/jcem-67-3-460

Cited by 693Hormonal and reproductive studiesEstrogen and related hormone effectsGrowth Hormone and Insulin-like Growth Factors

Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.

PLYMATE, STEPHEN R., MATEJ, LOUIS A., JONES, ROBERT E., FRIEDL, KARL E.·1988·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-67-3-460

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Abstract

Sex hormone-binding globulin (SHBG) production in humans has been thought to be stimulated by estrogens and thyroid hormone and inhibited by androgens. However, recent data indicate that SHBG production in vitro is stimulated by both androgens and estrogens. This study was designed to determine what other hormonal factors regulate SHBG production. Since hyperinsulinemia and hyperprolactinemia both occur in disease states in which low serum SHBG levels are found, the effects of insulin and PRL were compared to and/or studied in combination with estradiol (E2), T4, and testosterone (T) in a human hepatoma cell line (Hep G2). Hep G2 cells were grown to near confluence in medium including 10% fetal calf serum, and then 72-h experimental incubations were carried out which used only fetal calf serum-free medium. Compared to control incubations, both insulin (10(-8) mol/L) and PRL (10(-8) mol/L) decreased SHBG production from 65.0 +/- 0.6 (+/- SE) to 46.8 +/- 1.1 and 46.8 +/- 1.2 nmol/10(6) cells, respectively (P less than 0.01). Insulin also inhibited both E2 and T4-stimulated SHBG production. T stimulated SHBG production to the same degree as E2. Finally, both E2 and insulin significantly increased cell number, an important consideration when expressing the effect of a hormone on SHBG production in cultured cells. We conclude that insulin and PRL inhibit SHBG production and confirm that T4, T, and E2 stimulate SHBG production in vitro. These findings suggest that insulin and PRL may be important factors in the regulation of SHBG production in vivo.

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Insulin inhibits hepatic production of SHBG.
“Insulin is known to inhibit hepatic production of SHBG (31), and SHBG levels fall acutely during hyperglycemic-euglycemic clamp studies (32).”
From Low testosterone levels are common and associated with insulin resistance in men with diabetes (2008) · cites this paper as [31]

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Authors: PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E.
Affiliations: Madigan Army Medical Center (US)
ORCID: PLYMATE, STEPHEN R.
FRIEDL, KARL E.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1988-09
Volume: 67
Issue: 3
Pages: 460-464
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-67-3-460
OpenAlex: W2036203117
Cited by: 693
References: 24
Citations by year: 2026: 11 · 2025: 13 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 24 · 2020: 18 · 2019: 10 · 2018: 24 · 2017: 16 · 2016: 5 · 2015: 25 · 2014: 20 · 2013: 20 · 2012: 28
FWCI: 12.14
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: sex hormone-binding globulin, insulin, prolactin, HepG2 cells, hepatocellular carcinoma, estradiol, thyroxine, testosterone, hyperinsulinemia, hyperprolactinemia, cell proliferation
MeSH terms: Cell Line, Depression, Chemical, Estradiol, Carcinoma, Hepatocellular, Humans, Insulin, Liver Neoplasms, Prolactin, Sex Hormone-Binding Globulin, Testosterone, Thyroxine, Time Factors

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Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.

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