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Immunoassay of 6-Hydroxymelatonin Sulfate in Human Plasma and Urine: Abolition of the Urinary 24-Hour Rhythm with Atenolol*
Abstract
An assessment of the rhythmic characteristics of melatonin secretion in man and other species requires the determination of 24-h secretion profiles. Measurement of a major excreted metabolite would allow noninvasive study of pineal function, applicable in particular to pediatric and long term circadian rhythm studies. This report describes a simple and rapid RIA for 6-hydroxymelatonin sulfate in human plasma and urine. Physiological studies revealed that both plasma and urinary levels of 6-hydroxymelatonin sulfate were closely related to plasma melatonin, and that the urinary 24-h rhythm was abolished by the beta 1-adrenergic anagonist atenolol.
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Cited by
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Lewy, A. J., Cutler, N. L., & Sack, R. L. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000641 · Cited by 391
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Tordjman, S., Anderson, G. M., Pichard, N., Charbuy, H., & Touitou, Y. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.003 · Cited by 296
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Metadata
- Authors
- ARENDT, J., BOJKOWSKI, C., FRANEY, C., WRIGHT, J., & MARKS, V.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1985-06
- Volume
- 60
- Issue
- 6
- Pages
- 1166-1173
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2044341392
- Cited by
- 341
- References
- 0
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunoassay of 6-Hydroxymelatonin Sulfate in Human Plasma and Urine: Abolition of the Urinary 24-Hour Rhythm with Atenolol*. https://app.cochat.ai/papers/10.1210/jcem-60-6-1166
- The paper
- ARENDT, J., BOJKOWSKI, C., FRANEY, C., WRIGHT, J., & MARKS, V. (1985). Immunoassay of 6-Hydroxymelatonin Sulfate in Human Plasma and Urine: Abolition of the Urinary 24-Hour Rhythm with Atenolol*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-60-6-1166
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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