Blunted Growth Hormone (GH) Response to GH-Releasing Hormone in Hypothyroidism Resolves in the Euthyroid State*
Abstract
GH secretion is dependent upon thyroid hormone availability. In this study, the GH response to GH-releasing hormone (GHRH) was studied in a group of patients when they were hypothyroid and also when they were euthyroid. Hypothyroidism was associated with a significant reduction in both the peak GH response and the integrated GH secretory response to GHRH compared to those in the euthyroid state [4.7 +/- 1.6 (+/- SEM) vs. 12.2 +/- 3.9 ng/ml (P less than 0.025), and 349 +/- 116 ng vs. 986 +/- 304 ng ml-1 min-1 (P less than 0.025), respectively]. GH responsiveness was impaired within 2 weeks of discontinuation of T3 treatment in athyreotic subjects and was restored within 4 weeks of T4 treatment in one chronically hypothyroid subject. The results imply that a blunted GH response to GHRH in hypothyroidism is attributable to a primary pituitary defect that occurs rapidly and is reversible with attainment of the euthyroid state.
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Hypothyroid individuals demonstrate a blunted GH response to GHRH that is correctable with thyroid hormone replacement.
“Consistently, clinical studies have confirmed that hypothyroid individuals demonstrate a blunted GH response to GHRH that is correctable with thyroid hormone replacement (Williams et al., 1985).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Williams et al., 1985
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- Authors
- WILLIAMS, T., MAXON, H., THORNER, M. O., & FROHMAN, L. A.
- Affiliations
- University of Virginia (US)
- ORCID
- THORNER, MICHAEL O.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1985-09
- Volume
- 61
- Issue
- 3
- Pages
- 454-456
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2021679893
- Cited by
- 72
- References
- 23
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 2 · 2018: 1 · 2016: 1 · 2012: 1
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Virginia
- National Institutes of Health (5r01am030667-05, 5r01am032632-03)
- National Center for Research Resources (RR-0068)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- growth hormone secretion, growth hormone-releasing hormone, hypothyroidism, euthyroidism, thyroid hormones, triiodothyronine, levothyroxine, athyroidism
- MeSH terms
- Adult, Female, Humans, Hypothyroidism, Middle Aged, Growth Hormone, Growth Hormone-Releasing Hormone, Thyrotropin, Thyroxine, Triiodothyronine
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