Cited by 278Adrenal Hormones and DisordersStress Responses and CortisolCancer, Stress, Anesthesia, and Immune Response

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Responses of the Hypothalamic-Pituitary-Adrenal and Renin-Angiotensin Axes and the Sympathetic System During Controlled Surgical and Anesthetic Stress

UDELSMAN, ROBERT, NORTON, JEFFREY A., JELENICH, SANDRA E., GOLDSTEIN, DAVID S., LINEHAN, W. MARSTON, LORIAUX, D. LYNN, CHROUSOS, GEORGE P.·1987·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-64-5-986

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Abstract

We studied the responses of plasma CRH, ACTH, cortisol, norepinephrine, epinephrine, and renin activity in 11 patients undergoing parathyroid or thyroid surgery after identical preoperative sedation and during isoflurane (Forane) anesthesia. During surgical exploration, plasma CRH levels [10 +/- 2 (+/- SEM) pg/mL] remained at basal (unstimulated) levels, and plasma ACTH (11.5 +/- 1.4 pg/mL), cortisol (24 +/- 4 micrograms/dL), and epinephrine (35 +/- 10 pg/mL) concentrations remained within their normal morning ranges. The majority of the patients had no evidence of pulsatile ACTH secretion during the operation, but, rather, secreted ACTH and cortisol continuously. There was a small elevation of plasma norepinephrine and PRA which was associated with a small increase in heart rate and decrease in blood pressure. Anesthesia reversal, endotrachial extubation, and the early recovery period were associated with marked mean peak increases in plasma ACTH (173 +/- 45 pg/mL), cortisol (35 +/- 6 micrograms/dL), and epinephrine (220 +/- 56 pg/mL) and the return of plasma norepinephrine and PRA to basal levels. All hormones returned to basal levels by the first post-operative day. The data suggest that with modern anesthetic techniques patients undergoing neck surgery had mildly elevated plasma ACTH, cortisol, and epinephrine levels. Glucocorticoid secretion during the operation was maintained primarily by continuous rather than pulsatile ACTH secretion. The immediate postoperative perio…

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Some statistical methods useful in circulation research.
Wallenstein, S., Zucker, C. L., & Fleiss, J. L. (1980) · Circulation Research · doi:10.1161/01.res.47.1.1 · Cited by 3,867
Algorithms for the study of episodic hormone secretion
Merriam, G. R., & Wachter, K. W. (1982) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1982.243.4.e310 · Cited by 1,221
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965
Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms
Santen, R. J., & Bardin, C. W. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107454 · Cited by 706
Corticotropin-Releasing Activity of Monokines
Woloski, B. M. R. N. J., Smith, E. M., Meyer, W. J., Fuller, G. M., & Blalock, J. E. (1985) · Science · doi:10.1126/science.2997929 · Cited by 486
II. Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in man
Goldstein, D. S., Feuerstein, G., Izzo, J. L., Kopin, I. J., & Keiser, H. R. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90139-9 · Cited by 467
Self-citation
Measurement of Renin Activity, Concentration and Substrate in Rat Plasma by Radioimmunoassay of Angiotensin I
Ménard, J., & Catt, K. J. (1972) · Endocrinology · doi:10.1210/endo-90-2-422 · Cited by 454
Regulation of the in vitro antibody response by neuroendocrine hormones
Johnson, H. M., Smith, E. M., Torres, B. A., & Blalock, J. E. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.13.4171 · Cited by 402
Relationship between plasma norepinephrine and sympathetic neural activity.
Goldstein, D. S., McCarty, R. C., Polinsky, R. J., & Kopin, I. J. (1983) · Hypertension · doi:10.1161/01.hyp.5.4.552 · Cited by 352
Self-citation
The Corticotropin-Releasing Factor Stimulation Test
Chrousos, G. P., Schulte, H. M., Oldfield, E. H., Gold, P. W., Cutler, G. B., & Loriaux, D. L. (1984) · New England Journal of Medicine · doi:10.1056/nejm198403083101004 · Cited by 350
Self-citation

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Bornstein, S. R., Allolio, B., Arlt, W., Barthel, A., Don-Wauchope, A., Hammer, G. D., Husebye, E. S., Merke, D. P., Murad, M. H., Stratakis, C. A., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1710 · Cited by 1,769
Association of Perioperative Myocardial Ischemia with Cardiac Morbidity and Mortality in Men Undergoing Noncardiac Surgery
Mangano, D. T., Browner, W. S., Hollenberg, M., London, M. J., Tubau, J. F., & Tateo, I. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012273232601 · Cited by 986
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Devereaux, P. J., Goldman, L., Cook, D. J., Gilbert, K., Leslie, K., & Guyatt, G. H. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.050011 · Cited by 648
ATUALIZAÇÃO DA DIRETRIZ BRASILEIRA DE DISLIPIDEMIAS E PREVENÇÃO DA ATEROSCLEROSE - 2017
Faludi, A., Izar, M. C. D. O., Saraiva, J., Chacra, A., Bianco, H. T., Neto, A. A., Bertolami, A., Pereira, A., Lottenberg, A., Sposito, A. C., et al. (2017) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20170121 · Cited by 690
Intraadrenal interactions in the regulation of adrenocortical steroidogenesis.
Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., & Vinson, G. P. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0326 · Cited by 600
Acute Hypothalamic–Pituitary–Adrenal Responses to the Stress of Treadmill Exercise
Luger, A., Deuster, P. A., Kyle, S. B., Gallucci, W. T., Montgomery, L. C., Gold, P. W., Loriaux, D. L., & Chrousos, G. P. (1987) · New England Journal of Medicine · doi:10.1056/nejm198705213162105 · Cited by 516
Self-citation
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Devereaux, P. J., & Sessler, D. I. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1502824 · Cited by 481
Catecholamines and Stress
Goldstein, D. S. (1976) · Elsevier eBooks · doi:10.1016/c2013-0-05741-6 · Cited by 392
Self-citation
Clonidine in Patients Undergoing Noncardiac Surgery
Devereaux, P. J., Sessler, D. I., Leslie, K., Kurz, A. M., Mrkobrada, M., Alonso‐Coello, P., Villar, J. C., Sigamani, A., Biccard, B. M., Meyhoff, C. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401106 · Cited by 381
Perioperative myocardial ischemia in patients undergoing noncardiac surgery—I: Incidence and severity during the 4 Day perioperative period
Mangano, D. T., Hollenberg, M., Fegert, G., Meyer, M., London, M. J., Tubau, J. F., & Krupski, W. C. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90863-5 · Cited by 330
The Role of Epidural Anesthesia and Analgesia in Surgical Practice
Moraca, R. J., Sheldon, D. G., & Thirlby, R. C. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000094300.36689.ad · Cited by 320
Long-term Cardiac Prognosis Following Noncardiac Surgery
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Heterogeneous neurochemical responses to different stressors: a test of Selye’s doctrine of nonspecificity
Pacák, K., Palkovits, M., Yadid, G., Květňanský, R., Kopin, I. J., & Goldstein, D. S. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.4.r1247 · Cited by 292
Self-citation
Sympathetic system activity in obesity and metabolic syndrome
TENTOLOURIS, N., LIATIS, S., & KATSILAMBROS, N. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.010 · Cited by 260
Hormones, brain and stress.
de Kloet, E. R. (2003) · PubMed · Cited by 256
Dipyridamole thallium-201 scintigraphy as a preoperative screening test. A reexamination of its predictive potential. Study of Perioperative Ischemia Research Group.
Mangano, D. T., London, M. J., Tubau, J. F., Browner, W. S., Hollenberg, M., Krupski, W. C., Layug, E. L., & Massie, B. M. (1991) · Circulation · doi:10.1161/01.cir.84.2.493 · Cited by 238
Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome.
Fassbender, K. C., Schmidt, R., Mößner, R., Daffertshofer, M., & Hennerici, M. G. (1994) · Stroke · doi:10.1161/01.str.25.6.1105 · Cited by 236
Effects of Perioperative Dexmedetomidine Infusion in Patients Undergoing Vascular Surgery
Talke, P. O., Li, J., Jain, U., Leung, J. M., Drasner, K., Hollenberg, M., & Mangano, D. T. (1995) · Anesthesiology · doi:10.1097/00000542-199503000-00003 · Cited by 227
Cortisol Response in Relation to the Severity of Stress and Illness
Widmer, I. E., Puder, J. J., König, C., Pargger, H., Zerkowski, H. R., Girard, J., & Müller, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0354 · Cited by 225
The stress hormone copeptin: a new prognostic biomarker in acute illness
Christ‐Crain, M. (2010) · Swiss Medical Weekly · doi:10.4414/smw.2010.13101 · Cited by 216
Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level.
Mira, K., Morgenthaler, N. G., Suter‐Widmer, I., Puder, J. J., König, C., Müller-Stich, B. P., & Christ‐Crain, M. (2008) · PubMed · Cited by 202
Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vitro.
Calogero, A. E., Gallucci, W. T., Chrousos, G. P., & Gold, P. W. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113687 · Cited by 188
Self-citation
Perioperative myocardial ischemia in patients undergoing noncardiac surgery—II: Incidence and severity during the 1st week after surgery
Mangano, D. T., Wong, M. G., London, M. J., Tubau, J. F., & Rapp, J. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90864-6 · Cited by 188
Regulation and Dysregulation of the Hypothalamic-Pituitary-Adrenal Axis: The Corticotropin-Releasing Hormone Perspective
Chrousos, G. P. (1992) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30191-9 · Cited by 184
Self-citation
Effect of Mivazerol on Perioperative Cardiac Complications during Non-cardiac Surgery in Patients with Coronary Heart Disease
Oliver, M. F., Goldman, L., Julian, D. G., & Holme, I. (1999) · Anesthesiology · doi:10.1097/00000542-199910000-00014 · Cited by 181
Corticotropin-Releasing Hormone
Taylor, A. L., & Fishman, L. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190405 · Cited by 175
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Adrenomedullary, adrenocortical, and sympathoneural responses to stressors: a meta-analysis.
Goldstein, D. S., & Kopin, I. J. (2008) · PubMed · Cited by 164
Self-citation
Angiographic correlates of cardiac death and myocardial infarction complicating major nonthoracic vascular surgery
Ellis, S. G., HERTZER, N. R., Young, J. R., & Brener, S. J. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00130-0 · Cited by 163
Acute Effects of Intraoperative Multisite Ventricular Pacing on Left Ventricular Function and Activation/Contraction Sequence in Patients with Depressed Ventricular Function
Saxon, L. A., Kerwin, W. F., Cahalan, M. K., Kalman, J. M., OLGIN, J. E., Foster, E., Schiller, N. B., Shinbane, J. S., Lesh, M. D., & Merrick, S. H. (1998) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1998.tb00862.x · Cited by 162
Biphasic Changes in Hypothalamo-Pituitary-Adrenal Function during the Early Recovery Period after Major Abdominal Surgery*
NAITO, Y., Fukata, J., Tamai, S., Seo, N., Nakai, Y., Mori, K., & Imura, H. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-1-111 · Cited by 158
Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state
Taittonen, M. T., Kirvelä, O., Aantaa, R., & Kanto, J. (1997) · British Journal of Anaesthesia · doi:10.1093/bja/78.4.400 · Cited by 153
A double-blind study of perioperative steroid requirements in secondary adrenal insufficiency
Glowniak, J. V., & Loriaux, D. L. (1997) · Surgery · doi:10.1016/s0039-6060(97)90280-4 · Cited by 148
Self-citation
Hormonal and metabolic responses of untrained, moderately trained, and highly trained men to three exercise intensities
Deuster, P. A., Chrousos, G. P., Luger, A., Debolt, J. E., Bernier, L. L., Trostmann, U. H., Kyle, S. B., Montgomery, L. C., & Loriaux, D. L. (1989) · Metabolism · doi:10.1016/0026-0495(89)90253-9 · Cited by 148
Self-citation
The hypothalamic-pituitary-adrenal axis in critical illness: response to dexamethasone and corticotropin-releasing hormone
Reincke, M., Allolio, B., Würth, G., & Winkelmann, W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.1.8392081 · Cited by 147
The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity
Lockett, J., Inder, W. J., & Clifton, V. L. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae008 · Cited by 135
Endocrine and molecular responses to surgical stress
Udelsman, R., & Holbrook, N. J. (1994) · Current Problems in Surgery · doi:10.1016/0011-3840(94)90057-4 · Cited by 120
Self-citation
Patients with Rheumatoid Arthritis Undergoing Surgery: How Should We Deal with Antirheumatic Treatment?
Pieringer, H., Stuby, U., & Biesenbach, G. (2007) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2006.10.003 · Cited by 118
Perioperative medicine: NHLBI working group deliberations and recommendations
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Ventricular Arrhythmias in Patients Undergoing Noncardiac Surgery
O'Kelly, B. F. (1992) · JAMA · doi:10.1001/jama.1992.03490020065032 · Cited by 114
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Li, R., Liu, H., Dilger, J. P., & Lin, J. (2018) · BMC Anesthesiology · doi:10.1186/s12871-018-0543-3 · Cited by 110
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Donald, R. A., Perry, E. G., Wittert, G., Chapman, M., Livesey, J., Ellis, M. J., Evans, M. J., Yandle, T. G., & Espiner, E. A. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02142.x · Cited by 110
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Filos, K. S., & Lehmann, K. A. (1999) · European Surgical Research · doi:10.1159/000008627 · Cited by 109
Diagnosis and treatment of adrenal insufficiency including adrenal crisis: a Japan Endocrine Society clinical practice guideline [Opinion]
Yanase, T., Tajima, T., Katabami, T., Iwasaki, Y., Tanahashi, Y., Sugawara, A., Hasegawa, T., Mune, T., Oki, Y., Nakagawa, Y., et al. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0242 · Cited by 108
Stress and Reproduction: Physiologic and Pathophysiologic Interactions between the Stress and Reproductive Axes
Rabin, D. S., Gold, P. W., Margioris, A. N., & Chrousos, G. P. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2064-5_29 · Cited by 99
Self-citation
Applications of Steroid in Clinical Practice: A Review
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Use of supplemental steroids in patients having orthopaedic operations.
Friedman, R. J., Schiff, C., & Bromberg, J. S. (1995) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199512000-00002 · Cited by 91
The endocrine response to critical illness
Rolih, C. A., & Ober, K. P. (1995) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30093-1 · Cited by 90
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Winzeler, B. F., Zweifel, C., Nigro, N., Arici, B., Bally, M. R., Schüetz, P., Blum, C. A., Kelly, C., Berkmann, S., Huber, A., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4527 · Cited by 83
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Mellor, D. J., Stafford, K., Todd, S., Lowe, T., Gregory, N., BRUCE, R., & WARD, R. (2002) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.2002.tb10820.x · Cited by 83
Perioperative Management of Drug Therapy
Stafford‐Smith, M., Muir, H. A., & Hall, R. (1996) · Drugs · doi:10.2165/00003495-199651020-00005 · Cited by 80
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Perioperative evaluation and management of the patient with endocrine dysfunction
Schiff, R. L., & Welsh, G. A. (2003) · Medical Clinics of North America · doi:10.1016/s0025-7125(02)00150-5 · Cited by 75
Diagnostic Evaluation of Cushing’s Syndrome
Carpenter, P. C. (1988) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30412-2 · Cited by 76
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Perioperative Dexmedetomidine Improves Mortality in Patients Undergoing Coronary Artery Bypass Surgery
Ji, F., Li, Z., Young, N. J., Moore, P., & Liu, H. (2013) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2013.06.022 · Cited by 75
Evaluation of the Hypothalamic-Pituitary-Adrenal Axis Immediately After Pituitary Adenomectomy: Is Perioperative Steroid Therapy Necessary?*
HOUT, W. M., Arafah, B. M., Salazar, R., & Selman, W. R. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-6-1208 · Cited by 72
Perioperative catecholamine changes in cardiac risk patients
Sametz, Metzler, Gries, Porta, Sadjak, Supanz, & Juan (1999) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1999.00509.x · Cited by 72
Management of adrenal insufficiency during the stress of medical illness and surgery
Jung, C., & Inder, W. (2008) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2008.tb01686.x · Cited by 4
STEROIDS AND THE SURGICAL PATIENT
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Steroid cover for dental patients on long-term steroid medication: proposed clinical guidelines based upon a critical review of the literature
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Christ‐Crain, M., Jutla, S., Suter‐Widmer, I., Couppis, O., König, C., Pargger, H., Puder, J. J., Edwards, R., Müller-Stich, B. P., & Grossman, A. B. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2361 · Cited by 68
Catecholamine-glucocorticoid interactions during surgical stress
Udelsman, R., Goldstein, D. S., Loriaux, D. L., & Chrousos, G. P. (1987) · Journal of Surgical Research · doi:10.1016/0022-4804(87)90128-4 · Cited by 68
Self-citation
MANAGEMENT OF COMPLICATIONS OF GLUCOCORTICOID THERAPY
Keenan, G. F. (1997) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70398-1 · Cited by 65
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Ezhevskaya, A. A., Mlyavykh, S. G., & Anderson, D. G. (2013) · Spine · doi:10.1097/brs.0b013e318290ff26 · Cited by 62
Pulsatile activation of the hypothalamic-pituitary-adrenal axis during major surgery
Calogero, A. E., Norton, J. A., Sheppard, B. C., Listwak, S. J., Cromack, D. T., Wall, R. T., Jensen, R. T., & Chrousos, G. P. (1992) · Metabolism · doi:10.1016/0026-0495(92)90164-6 · Cited by 65
Self-citation
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Woolf, P. D., Cox, C., Kelly, M., Nichols, D., McDonald, J. V., & Hamill, R. W. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb01838.x · Cited by 60
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Darmon, P., Dadoun, F., Boullu-Ciocca, S., Grino, M., Alessi, M.-C., & Dutour, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00654.2005 · Cited by 59
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Koch, K. L., Stern, R. M., Vasey, M. W., Seaton, J. F., Demers, L. M., & Harrison, T. S. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.2.e304 · Cited by 60
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Roth-Isigkeit, A., Brechmann, J., DIBBELT, L., Sievers, H. H., Raasch, W., & Schmucker, P. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03347280 · Cited by 57
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Adrenal insufficiency
Kumar, R., & Wassif, W. (2022) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2021-207895 · Cited by 58
Characterization of an Adrenocorticotropin (ACTH) Receptor Promoter Polymorphism Leading to Decreased Adrenal Responsiveness to ACTH
Slawik, M., Reisch, N., Zwermann, O., Maser‐Gluth, C., Stahl, M., Klink, A., Reincke, M., & Beuschlein, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032010 · Cited by 54
Con: Early extubation is not preferable to late extubation in patients undergoing coronary artery surgery
Siliciano, D. (1992) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1016/1053-0770(92)90020-8 · Cited by 54
Acute Postoperative Pain Is Associated With Myocardial Injury After Noncardiac Surgery
Turan, A., Leung, S. M., Bajracharya, G. R., Babazade, R., Barnes, T., Schacham, Y. N., Mao, G., Zimmerman, N., Ruetzler, K., Maheshwari, K. K., et al. (2020) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005033 · Cited by 53
Inflammatory Bowel Disease: Perioperative Pharmacological Considerations
Kumar, A., Aurón, M., Aneja, A., Mohr, F., Jain, A. K., & Shen, B. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2011.0074 · Cited by 52
Hyperreninemic hypoaldosteronism after chronic stress in the rat.
Aguilera, G., Kiss, A., & Akbaşak, B. S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118189 · Cited by 52
Psychological factors in surgical stress: Implications for management
Salmon, P. (1992) · Clinical Psychology Review · doi:10.1016/0272-7358(92)90020-9 · Cited by 52
II Diretriz de Avaliação Perioperatória da Sociedade Brasileira de Cardiologia
Feitosa, A. C. R., Marques, A. C., Caramelli, B., Ferreira, B. M. A., Polanczyk, C. A., Jardim, C., Vieira, C. L. Z., Pinho, C., Calderaro, D., Gualandro, D. M., et al. (2011) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2011000800001 · Cited by 51
The Adrenal Cortex and its Disorders
Miller, W. L. (2009) · Wiley eBooks · doi:10.1002/9781444316728.ch13 · Cited by 51
Management of adrenal insufficiency in different clinical settings
Hahner, S., & Allolio, B. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.14.2407 · Cited by 49
Supplemental corticosteroids for dental patients with adrenal insufficiency
Miller, C. S., Little, J. W., & Falace, D. A. (2001) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2001.0092 · Cited by 51
Critical Care Issues in the Patient After Major Joint Replacement
Memtsoudis, S. G., Rosenberger, P., & Walz, J. M. (2007) · Journal of Intensive Care Medicine · doi:10.1177/0885066606297692 · Cited by 47
Preoperative inhibition of angiotensin-converting enzyme improves systemic and renal haemodynamic changes during aortic abdominal surgery
Licker, M. J., Bednarkiewicz, M., Neidhart, P., Prêtre, R., Montessuit, M., Favre, H., & Morel, D. R. (1996) · British Journal of Anaesthesia · doi:10.1093/bja/76.5.632 · Cited by 47
Hormonal Responses to the Stress of Exercise
Luger, A., Deuster, P. A., Gold, P. W., Loriaux, D. L., & Chrousos, G. P. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2064-5_22 · Cited by 48
Self-citation
Comparison of Patient-Controlled Analgesia and Nurse-Controlled Infusion Analgesia after Cardiac Surgery
Myles, P. S., Buckland, M., Cannon, G. B., Bujor, M. A., Langley, M., Breaden, A., Salamonsen, R. F., & Davis, B. B. (1994) · Anaesthesia and Intensive Care · doi:10.1177/0310057x9402200605 · Cited by 47
The Hypothalamic-Pituitary-Adrenal Axis in Critical Illness
Schüetz, P., & Müller-Stich, B. P. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.09.013 · Cited by 45
Stress hormone responses to major intra-abdominal surgery during and immediately after sevoflurane-nitrous oxide anaesthesia in elderly patients
Furuya, K., Shimizu, R., Hirabayashi, Y., Ishii, R., & Fukuda, H. (1993) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03009513 · Cited by 45
Cortisol response to operative stress with anesthesia in healthy children
Taylor, L. K., Auchus, R. J., Baskin, L. S., & Miller, W. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2148 · Cited by 44
The hypothalamic–pituitary–adrenal axis in critical illness
Venkataraman, S. T., Munoz, R. A., Cândido, C., & Witchel, S. F. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-007-9058-9 · Cited by 45
The Adrenal Cortex
Stewart, P. M., & Krone, N. P. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00015-8 · Cited by 45
Adrenal cortex and its disorders
Miller, W. L., & Flück, C. E. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00022-6 · Cited by 45
Equine pleuropneumonia
Raidal, S. L. (1995) · British Veterinary Journal · doi:10.1016/s0007-1935(95)80175-8 · Cited by 43
Regulation of Rat Hypothalamic Corticotropin-Releasing Hormone Secretion in vitro: Potential Clinical Implications
Calogero, A. E., Bernardini, R., Gold, P. W., & Chrousos, G. P. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2064-5_13 · Cited by 43
Self-citation
Light Versus Heavy Sedation After Cardiac Surgery
Hall, R. I., MacLaren, C., Stafford‐Smith, M., McIntyre, A. J., Allen, C. T. B., Murphy, J. T., Sullivan, J. A., Wood, J. R., Ali, I., & Kinley, E. C. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199711000-00004 · Cited by 42
Normalized Early Postoperative Cortisol and ACTH Values Predict Nonremission After Surgery for Cushing Disease
Asuzu, D. T., Chatain, G. P., Hayes, C. P., Benzo, S., McGlotten, R., Keil, M. F., Beri, A., Sharma, S. T., Nieman, L. K., Lodish, M. B., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3908 · Cited by 41
Evaluation of the effect of stress on the blood–brain barrier: critical role of the brain perfusion time
Ovadia, H., Abramsky, O., Feldman, S., & Weidenfeld, J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02361-7 · Cited by 41

Authors: UDELSMAN, R., NORTON, J. A., JELENICH, S. E., GOLDSTEIN, D. S., LINEHAN, W. M., LORIAUX, D. L., & CHROUSOS, G. P.
Affiliations: National Institutes of Health (US)
Johns Hopkins University (US)
ORCID: NORTON, JEFFREY A.
GOLDSTEIN, DAVID S.
LINEHAN, W. MARSTON
CHROUSOS, GEORGE P.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1987-05
Volume: 64
Issue: 5
Pages: 986-994
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-64-5-986
OpenAlex: W1971663522
Cited by: 278
References: 27
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 4 · 2019: 8 · 2018: 13 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 10 · 2012: 5
FWCI: 8.10
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Keywords: hypothalamic-pituitary-adrenal axis, renin-angiotensin system, sympathetic nervous system, surgical stress, parathyroidectomy, thyroid surgery, isoflurane anesthesia, ACTH secretion, cortisol, epinephrine, norepinephrine, plasma renin activity, postoperative recovery, anesthesia reversal, extubation
MeSH terms: Adrenocorticotropic Hormone, Adult, Aged, Anesthesia, Corticotropin-Releasing Hormone, Epinephrine, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Norepinephrine, Parathyroid Glands, Pituitary-Adrenal System, Renin, Renin-Angiotensin System, Stress, Physiological, Surgical Procedures, Operative, Sympathetic Nervous System, Thyroid Gland

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Responses of the Hypothalamic-Pituitary-Adrenal and Renin-Angiotensin Axes and the Sympathetic System During Controlled Surgical and Anesthetic Stress

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