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Cited by 260Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityDiabetes, Cardiovascular Risks, and Lipoproteins

Sympathetic system activity in obesity and metabolic syndrome

TENTOLOURIS, N., LIATIS, S., KATSILAMBROS, N.·2006·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1367.010
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Abstract

Abstract: Obesity is a very common disease worldwide, resulting from a disturbance in the energy balance. The metabolic syndrome is also a cluster of abnormalities with basic characteristics being insulin resistance and visceral obesity. The major concerns of obesity and metabolic syndrome are the comorbidities, such as type 2 diabetes, cardiovascular disease, stroke, and certain types of cancers. Sympathetic nervous system (SNS) activity is associated with both energy balance and metabolic syndrome. Sympathomimetic medications decrease food intake, increase resting metabolic rate (RMR), and thermogenic responses, whereas blockage of the SNS exerts opposite effects. The contribution of the SNS to the daily energy expenditure, however, is small (∼5%) in normal subjects consuming a weight maintenance diet. Fasting suppresses, whereas meal ingestion induces SNS activity. Most of the data agree that obesity is characterized by SNS predominance in the basal state and reduced SNS responsiveness after various sympathetic stimuli. Weight loss reduces SNS overactivity in obesity. Metabolic syndrome is characterized by enhanced SNS activity. Most of the indices used for the assessment of its activity are better associated with visceral fat than with total fat mass. Visceral fat is prone to lipolysis: this effect is mediated by catecholamine action on the sensitive β 3‐adrenoceptors found in the intraabdominal fat. In addition, central fat distribution is associated with disturbances in the hypothalamo‐pituitary‐adrenal axis, suggesting that a disturbed axis may be implicated in the development of the metabolic syndrome. Furthermore, SNS activity induces a proinflammatory state by IL‐6 production, which in turn results in an acute phase response. The increased levels of inflammatory markers seen in the metabolic syndrome may be elicited, at least in part, by SNS overactivity. Intervention studies showed that the disturbances of the autonomic nervous system seen in the metabolic syndrome are reversible.

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  • SNS dysfunction is closely associated with metabolic syndrome, oncogenic activation, neoplastic growth and tumor initiation.

    “SNS dysfunction is closely associated with metabolic syndrome, oncogenic activation, neoplastic growth and tumor initiation (Lee et al., 2010; Magnon et al., 2013; Tentolouris et al., 2006).”

    From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Tentolouris et al., 2006

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Authors
TENTOLOURIS, N., LIATIS, S., & KATSILAMBROS, N.
Affiliations
National and Kapodistrian University of Athens (GR)
Corresponding author
TENTOLOURIS, N.
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2006-11
Volume
1083
Issue
1
Pages
129-152
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1367.010
OpenAlex
W2095951402
Cited by
260
References
137
Citations by year
2026: 6 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 22 · 2016: 10 · 2015: 24 · 2014: 16 · 2013: 23 · 2012: 14
FWCI
1.84
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 16 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
sympathetic nervous system, obesity, metabolic syndrome, energy balance, visceral fat, beta3-adrenergic receptor, lipolysis, hypothalamic-pituitary-adrenal axis, inflammation, interleukin-6, weight loss, sympathomimetic drugs, thermogenesis, autonomic nervous system
MeSH terms
Eating, Energy Metabolism, Humans, Obesity, Sympathetic Nervous System, Weight Gain, Weight Loss, Leptin, Metabolic Syndrome

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