Effects of suramin on the function and structure of the adrenal cortex in the cynomolgus monkey
Abstract
There have been reports of adrenal failure in patients treated with suramin, an agent that has recently been used as therapy for acquired immune deficiency syndrome. We conducted this study to assess the effect of suramin on adrenal function and structure in a primate, the cynomolgus monkey. Five male monkeys were treated with suramin (800 mg/m2, im) once a week, for 5 weeks. Five other animals (controls) received saline. The treated animals had progressive elevations of plasma ACTH (P less than 0.05) and PRA (P less than 0.02) and decreased serum cortisol responses 30 min after the administration of synthetic ACTH (P less than 0.05) compared to controls. There was disruption of the architecture of the adrenal cortex, a diffuse inflammatory cell infiltrate, and thinning of the zona glomerulosa and zona fasciculata in the suramin-treated animals. We conclude that suramin is toxic to adrenal cortical tissue and might be useful in treating conditions with adrenal cortical hyperfunction, such as adrenal cortical carcinoma and Cushing's syndrome.
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Suramin had been found to induce adrenal insufficiency in humans and to have adrenolytic activity in animal experiments, where it led to inflammatory changes of the adrenal cortex.
“Suramin, a compound used traditionally for the treatment of sleeping sickness, had been found to induce adrenal insufficiency in humans and to have adrenolytic activity in animal experiments, where it led to inflammatory changes of the adrenal cortex (310, 311).”
From Adrenocortical carcinoma (2014) · cites this paper as [310]
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- Authors
- FEUILLAN, P., RAFFELD, M., STEIN, C. A., LIPFORD, N., REHNQUIST, D., MEYERS, C. E., LAROCCA, R. V., & CHROUSOS, G. P.
- Affiliations
- National Institutes of Health (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1987-07
- Volume
- 65
- Issue
- 1
- Pages
- 153-158
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2146858631
- Cited by
- 40
- References
- 16
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2017: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- suramin, adrenal cortex, adrenal insufficiency, ACTH, renin-angiotensin system, cortisol, zona glomerulosa, zona fasciculata, Cushing's syndrome, adrenocortical carcinoma, Macaca fascicularis
- MeSH terms
- Adrenal Cortex, Adrenocorticotropic Hormone, Alanine Transaminase, Animals, Blood Urea Nitrogen, Creatinine, Hematocrit, Hydrocortisone, Macaca fascicularis, Male, Renin, Suramin
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