Cited by 108Growth Hormone and Insulin-like Growth FactorsThyroid Disorders and TreatmentsHormonal and reproductive studies

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

The Acute Effects of Human Growth Hormone Administration on Thyroid Function in Normal Men*

GRUNFELD, CARL, SHERMAN, BARRY M., CAVALIERI, RALPH R.·1988·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-67-5-1111

Open this paper in CoChat — free account

Abstract

GH replacement therapy may lead to alterations in serum TSH and/or thyroid hormone values in GH-deficient patients, but there is no consensus on the explanation for these changes. We examined the effect of GH administration (0.125 mg, sc, daily for 4 days) on thyroid function in 20 normal men. Serum T4 levels decreased by 8%, and serum free T4 index values decreased by 5%. In contrast, serum T3 levels increased by 21%; serum rT3 did not change. These changes were accompanied by a 54% decrease in the mean serum TSH level. While it is not possible to draw conclusions about hormone production and disposal rates from changes in serum levels, these data are most consistent with enhanced extrathyroidal (including intrapituitary) conversion of T4 to T3 and a compensatory decrease in TSH secretion.

Integrity signals

Registry

Crossref · 10.1210/jcem-67-5-1111

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Induction of Immunoreactive Somatomedin C in Human Serum by Growth Hormone: Dose-Response Relationships and Effect on Chromatographic Profiles*
Copeland, K. C., Underwood, L. E., & Wyk, J. J. V. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-50-4-690 · Cited by 354
Reversible Hypothyroidism in Growth Hormone-Deficient Children Treated with Human Growth Hormone
Lippe, B. M., Herle, A. J. V., LAFRANCHI, S. H., Uller, R. P., Lavin, N., & Kaplan, S. A. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-40-4-612 · Cited by 133
Enhanced Peripheral Conversion of Thyroxine to Triiodothyronine During hGH Therapy in GH Deficient Children
Sato, T., Suzuki, Y., Taketani, T., ISHICURO, K., MASUYAMA, T., Takata, I., Sano, M., KAWASHIMA, H., Koizumi, S., & Nakajima, H. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-2-324 · Cited by 105
Inhibition of Thyrotropin-Releasing Hormone-Mediated Secretion of Thyrotropin by Human Growth Hormone
Root, A. W., Snyder, P. J., Rezvani, I., DiGeorge, A. M., & Utiger, R. D. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-1-103 · Cited by 90
Evaluation of a Simplified Technique for the Specific Measurement of Serum Thyroxine Concentration
Braverman, L. E., Vagenakis, A. G., Foster, A. E., & Ingbar, S. H. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-32-4-497 · Cited by 82
ABNORMAL THYROXINE METABOLISM IN HYPOSOMATOTROPHIC DWARFISM AND INHIBITION OF RESPONSIVENESS TO TRH DURING GH THERAPY
Porter, B. A., Refetoff, S., Rosenfield, R. L., DeGroot, L. J., Fang, V. S., & Stark, V. J. (1973) · PEDIATRICS · doi:10.1542/peds.51.4.668 · Cited by 74
Action of Human Growth Hormone (hGH) on Extrathyroidal Conversion of Thyroxine (T4) to Triiodothyronine (T3) in Children with Hypopituitarism
Rezvani, I., DiGeorge, A. M., Dowshen, S. A., & Bourdony, C. J. (1981) · Pediatric Research · doi:10.1203/00006450-198101000-00002 · Cited by 66
Effect of Human Growth Hormone on Thyroidal Secretion, Radiothyroxine Turnover and Transport in Man
Oliner, L., & BALLANTINE, J. J. (1968) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-28-5-603 · Cited by 30
Parameters of thyroid function in patients with active acromegaly
Corrigan, D. F., Wartofsky, L., Dimond, R. C., Schaaf, M., Earll, J. M., Rogers, J. E., WRIGHT, F. D., & Burman, K. D. (1978) · Metabolism · doi:10.1016/0026-0495(78)90166-x · Cited by 10

Show all 9 references

Sorted by citations

Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“Growth hormone (GH) replacement therapy in GH-deficient subjects decreases serum T4 and rT3 levels, with a concomitant rise in serum T3 levels (196, 197).”
The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency
Salomon, F., Cuneo, R. C., Hesp, R., & Sönksen, P. H. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912283212605 · Cited by 1,326
Treatment of adults with growth hormone (GH) deficiency with recombinant human GH.
Bengtsson, B. Å., Edén, S., Lönn, L., Kvist, H., Stokland, A. M., Lindstedt, G., Bosaeus, I. G., Tölli, J., Sjöström, L., & Isaksson, O. G. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432773 · Cited by 780
Selenium, the Thyroid, and the Endocrine System
Köhrle, J., Jakob, F. J., Contempré, B., & Dumont, J. E. (2005) · Endocrine Reviews · doi:10.1210/er.2001-0034 · Cited by 535
The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition
Binnerts, A., Swart, G. R., Wilson, J. H. P., Hoogerbrugge, N., Pois, H. A. P., Birkenhager, J. C., & Lamberts, S. W. J. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02287.x · Cited by 315
Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy
Smith, T. J., & Janssen, J. A. M. J. L. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00066 · Cited by 235
Serum lipid levels in growth hormone-deficient men
de Boer, H., Blok, G. J., Voerman, H. J., Phillips, M., & Schouten, J. A. (1994) · Metabolism · doi:10.1016/0026-0495(94)90245-3 · Cited by 198
Effects of Growth Hormone Therapy on Thyroid Function of Growth Hormone-Deficient Adults with and without Concomitant Thyroxine-Substituted Central Hypothyroidism*
JøRGENSEN, J. O. L., PEDERSEN, S. A., LAURBERG, P., WEEKE, J., SKAKKEBÆK, N. E., & CHRISTIANSEN, J. S. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-6-1127 · Cited by 192
Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults
Jørgensen, J. O. L., Møller, J., Laursen, T., Ørskov, H., Christiansen, J. S., & Weeke, J. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb01826.x · Cited by 162
Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow-up in adult patients
Alexopoulou, O., Beguin, C., De Nayer, P., & Maiter, D. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500001 · Cited by 135
The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults
Weaver, J. U., Theventhiran, L., Noonan, K., Burrin, J. M., Taylor, N., Norman, M. R., & Monson, J. P. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb01830.x · Cited by 120
Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients
Agha, A., Walker, D., Perry, L., Drake, W. M., Chew, S. L., Jenkins, P. J., Grossman, A. B., & Monson, J. P. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02688.x · Cited by 113
Recombinant Human GH Replacement Therapy and Thyroid Function in a Large Group of Adult GH-Deficient Patients: When Does L-T4 Therapy Become Mandatory?
Porretti, S., Giavoli, C., Ronchi, C. L., Lombardi, G., Zaccaria, M., Valle, D., Arosio, M., & Beck‐Peccoz, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8479 · Cited by 112
Human Growth
Roche, A. F., & Sun, S. S. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525681 · Cited by 110
The GH/IGF-1 Axis and Heart Failure
Castellano, G., Affuso, F., Conza, P. D., & Fazio, S. (2009) · Current Cardiology Reviews · doi:10.2174/157340309788970306 · Cited by 91
Central hypothyroidism
Lania, A., Persani, L., & Beck-Peccoz, P. (2008) · Pituitary · doi:10.1007/s11102-008-0122-6 · Cited by 85
Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver
Darras, V. M., Berghman, L., Vanderpooten, A., & Kuhn, E. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81133-7 · Cited by 72
Applications for non-invasive thyroid hormone measurements in mammalian ecology, growth, and maintenance
Behringer, V., Deimel, C., Hohmann, G., Negrey, J. D., Schaebs, F. S., & Deschner, T. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.07.011 · Cited by 75
Effects of growth hormone administration on fuel oxidation and thyroid function in normal man
Møller, J., Jørgensen, J. O. L., Møller, N., Christiansen, J. S., & Weeke, J. (1992) · Metabolism · doi:10.1016/0026-0495(92)90312-x · Cited by 69
Efficacy of a Long-Acting Growth Hormone (GH) Preparation in Patients with Adult GH Deficiency
Hoffman, A. R., Biller, B. M. K., Cook, D. M., Baptista, J., Silverman, B. L., Dao, L. N., Attie, K. M., Fielder, P. J., Maneatis, T. J., & Lippe, B. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0928 · Cited by 68
Recombinant hGH replacement therapy and the hypothalamus–pituitary–thyroid axis in children with GH deficiency: when should we be concerned about the occurrence of central hypothyroidism?
Giavoli, C., Porretti, S., Ferrante, E., Cappiello, V., Ronchi, C. L., TRAVAGLINI, P., Epaminonda, P., Arosio, M., & Beck‐Peccoz, P. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01892.x · Cited by 61
Acute pretranslational regulation of type III iodothyronine deiodinase by growth hormone and dexamethasone in chicken embryos
der Geyten, S. V., Buys, N., Sanders, J. P., Decuypere, E. M. P., Visser, T. J., Kühn, E. R., & Darras, V. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00218-4 · Cited by 61
The interaction between growth hormone and the thyroid axis in hypopituitary patients: Interaction between growth hormone and thyroid axis
Behan, L. A., Monson, J. P., & Agha, A. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03815.x · Cited by 53
Long-term effects of growth hormone replacement therapy on thyroid function in adults with growth hormone deficiency
Losa, M., Scavini, M., Gatti, E., Rossini, A., Madaschi, S., Formenti, I., Caumo, A., Stidley, C. A., & Lanzi, R. (2008) · Thyroid · doi:10.1089/thy.2008.0266 · Cited by 53
Growth and thyroid function in children treated with growth hormone
Pirazzoli, P., Cacciarl, E., Mandini, M., Sganga, T., Capelli, M., Cicognani, A., & Gualandi, S. C. (1992) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81190-4 · Cited by 53
Repeated Administration of Recombinant Human Insulin-Like Growth Factor-I in Patients After Gastric Surgery
Goeters, C., Mertes, N., Tacke, R., Bolder, U., Kuhmann, M., Lawin, P., & Löhlein, D. (1995) · Annals of Surgery · doi:10.1097/00000658-199511000-00007 · Cited by 53
Thyroid hormones and growth hormone secretion
Valcavi, R., Zini, M., & Portioli, I. (1992) · Journal of Endocrinological Investigation · doi:10.1007/bf03348744 · Cited by 52
Changes in Thyroid Hormone Levels during Growth Hormone Therapy in Initially Euthyroid Patients: Lack of Need for Thyroxine Supplementation
Wyatt, D. T., Gesundheit, N., & Sherman, B. M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5202 · Cited by 52
Self-citation
Growth hormone stimulates hepatic thyroxine 5′-monodeiodinase activity and 3,5,3′-triiodothyronine levels in rainbow trout (Salmo gairdneri)
MacLatchy, D. L., & Eales, J. G. (1990) · General and Comparative Endocrinology · doi:10.1016/0016-6480(90)90002-4 · Cited by 48
Growth hormone does not increase thyroid size in the absence of thyrotropin: a study in adults with hypopituitarism
Cheung, N. W., Lou, J. C., & Boyages, S. C. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.3.1179 · Cited by 45
Metabolic Consequences of 5-Year Growth Hormone (GH) Therapy in Children Treated with GH for Idiopathic Short Stature
Saenger, P. H., Attie, K. M., DiMartino-Nardi, J., Hintz, R. L., Frahm, L., & Frane, J. W. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5089 · Cited by 41
Low dose continuously infused growth hormone results in increased lipoprotein(a) and decreased low density lipoprotein cholesterol concentrations in middle‐aged men
Oscarsson, J., Ottosson, M., Wiklund, O., Mårin, P., Vikman, K., Björntorp, P. A., & Edén, S. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb03791.x · Cited by 41
Endogenous growth hormone controls high plasma levels of 3,3′,5-triiodothyronine (T3) in growing chickens by decreasing the T3-degrading type III deiodinase activity
Darras, V., Rudas, P., Visser, T. J., Hall, T. R., HUYBRECHTS, L. M., Vanderpooten, A., Berghman, L. R., Decuypere, E. M. P., & Kühn, E. R. (1993) · Domestic Animal Endocrinology · doi:10.1016/0739-7240(93)90008-y · Cited by 40
State of the art paper Thyroid diseases in patients with acromegaly
Dąbrowska, A. M., Tarach, J. S., Kurowska, M., & Nowakowski, A. M. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.36924 · Cited by 34
Thyroid function in non-growth hormone-deficient short children during a placebo-controlled double blind trial of recombinant growth hormone therapy
Rose, S. R., Leong, G. M., Yanovski, J. A., Blum, D., Heavner, G., Barnes, K. M., Chipman, J. J., Dichek, H. L., Jacobsen, J., & Klein, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829634 · Cited by 31
Effects of growth hormone replacement therapy on levels of cortisol and cortisol-binding globulin in hypopituitary adults
Tschöp, M., Lahner, H., Feldmeier, H., Grasberger, H., Morrison, K. M., Janssen, O. E., Attanasio, A., & Strasburger, C. J. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430769 · Cited by 31
Evidence for a negative feedback in the control of eel growth hormone by thyroid hormones
Rousseau, K., Belle, N. L., Sbaihi, M., Marchelidon, J., Schmitz, M., & Dufour, S. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1750605 · Cited by 31
Performance, plasma hormones, histochemical and biochemical muscle traits, and meat quality of pigs administered exogenous somatotropin between 30 or 60 kilograms and 100 kilograms body weight1
Lafaucheur, L., Missohou, A., Ecolan, P., Monin, G., & Bonneau, M. (1992) · Journal of Animal Science · doi:10.2527/1992.70113401x · Cited by 31
Hormonal Regulation of Growth and Metabolic Effects of Growth Hormone
Kaplan, S. L. (1999) · Comprehensive physiology · doi:10.1002/cphy.cp070505 · Cited by 29
Effects of recombinant human growth hormone on basal metabolic rate in adults with pituitary deficiency
Stenlöf, K., Sjöström, L., Lönn, L., Bosaeus, I. G., Kvist, H., Tölli, J., Lindstedt, G., & Bengtsson, B. (1995) · Metabolism · doi:10.1016/0026-0495(95)90291-0 · Cited by 27
GH Deficiency and Replacement Therapy in Hypopituitarism: Insight Into the Relationships With Other Hypothalamic-Pituitary Axes
Profka, E., Rodari, G., Giacchetti, F., & Giavoli, C. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.678778 · Cited by 26
Proteolytic Cleavage of Human Growth Hormone (hGH) by Rat Tissuesin Vitro: Influence on the Kinetics of Exogenously Administered hGH*
Wroblewski, V. J., Masnyk, M., & Becker, G. W. (1991) · Endocrinology · doi:10.1210/endo-129-1-465 · Cited by 25
Recombinant human growth hormone treatment at low doses does not significantly change thyroid function in growth hormone deficient adults
Amato, G., Izzo, G., Salzano, I., & Bellastella, A. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03349017 · Cited by 23
Growth Hormone (GH)-Deficiency in Adults: Clinical Features and Effects of GH Substitution
Jørgensen, J. O. L., Maller, J., Wolthers, T., Vahl, N., Juul, A., Skakkehaek, N. E., & Christiansen, J. S. (1994) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1994.7.4.283 · Cited by 23
Low FT4 Concentrations around the Start of Recombinant Human Growth Hormone Treatment: Predictor of Congenital Structural Hypothalamic-Pituitary Abnormalities?
van Iersel, L., van Santen, H. M., Zandwijken, G. R. J., Zwaveling‐Soonawala, N., Hokken-Koelega, A., & van Trotsenburg, A. S. P. (2018) · Hormone Research in Paediatrics · doi:10.1159/000486033 · Cited by 22
Thyroid function in short children born small‐for‐gestational age (SGA) before and during GH treatment
Kort, S. W. K. D., Willemsen, R. H., van der Kaay, D. C. M., van Dijk, M., Visser, T. J., & Hokken-Koelega, A. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03195.x · Cited by 22
Evolving pituitary hormone deficits in primarily isolated GHD: a review and experts’ consensus
Binder, G., Schnabel, D., Reinehr, T., Pfäffle, R. W., Dörr, H., Bettendorf, M., Hauffa, B. P., & Woelfle, J. (2020) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-020-00108-2 · Cited by 21
Recombinant growth hormone: A new cardiovascular drug therapy
Gomberg‐Maitland, M., & Frishman, W. H. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90469-x · Cited by 21
Insulin-like growth factor I reduces thyroid hormone receptors in the rat liver. Evidence for a feed-back loop regulating the peripheral thyroid hormone action
Pellizas, C. G., Coleoni, A. H., Costamagna, M. E., Fulvio, M. D., & Masini-Repiso, A. M. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1580087 · Cited by 21
Determinants of growth
Roche, A. F., & Sun, S. S. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525681.004 · Cited by 20
Focus on GH deficiency and thyroid function
Giavoli, C., Profka, E., Rodari, G., Lania, A. G., & Beck‐Peccoz, P. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.02.003 · Cited by 20
The effect of recombinant IGF‐I on anterior pituitary function in healthy volunteers
Trainer, P. J., Holly, J. M. P., Medbak, S., REES, L. H., & BESSER, G. M. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02796.x · Cited by 20
Growth hormone corrects acidosis-induced renal nitrogen wasting and renal phosphate depletion and attenuates renal magnesium wasting in humans
Mahlbacher, K., Sicuro, A., Gerber, H., Hulter, H. N., & Krapf, R. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90177-4 · Cited by 19
Central Hypothyroidism Related to Pituitary Adenomas: Low Incidence of Central Hypothyroidism in Patients With Acromegaly
Takamizawa, T., Horiguchi, K., Nakajima, Y., Okamura, T., Ishida, E., Matsumoto, S., Yoshino, S., Yamada, E., Saitoh, T., Ozawa, A., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00466 · Cited by 18
A Risk-Benefit Assessment of Growth Hormone Use in Children
Blethen, S. L., & MacGillivray, M. H. (1997) · Drug Safety · doi:10.2165/00002018-199717050-00003 · Cited by 18
Growth hormone therapy in Turner's syndrome: one versus two daily injections
Schepper, J. D., Craen, M., Massa, G., Heinrichs, C., Maes, M., Caju, M. D., Rausin, L., & Bourguignon, J.-P. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.2.489 · Cited by 18
Diurnal Variations in Twenty-Four-Hour Energy Expenditure During Growth Hormone Treatment of Adults with Pituitary Deficiency
Stenlöf, K., Johansson, J.-O., Lönn, L., Sjöström, L., & Bengtsson, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.4.1255 · Cited by 16
Prolactin insufficiency but normal thyroid hormone levels after cranial radiotherapy in long‐term survivors of childhood leukaemia
Follin, C., Link, K., Wiebe, T., Moëll, C., Björk, J., & Erfurth, E. M. (2012) · Clinical Endocrinology · doi:10.1111/cen.12111 · Cited by 15
Thyroid function in children with growth hormone deficiency during long-term growth hormone replacement therapy
Witkowska–Sędek, E., Borowiec, A., Majcher, A., Sobol, M., Rumińska, M., & Pyrżak, B. (2018) · Central European Journal of Immunology · doi:10.5114/ceji.2018.80043 · Cited by 14
Preserved thyroidal secretion of thyroxione in acromegalic patients with suppressed hypophyseal secretion of thyrotrophin
Yoshinari, M., Tokuyama, T., Kuroda, T., Sato, K., Okazawa, K., Mizokami, T., Okamura, K., & Fujishima, M. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb01460.x · Cited by 14
Effect of growth hormone therapy on thyroid status of girls with Turner's syndrome*
Massa, G., de Zegher, F., & Vanderschueren‐Lodeweyckx, M. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb00295.x · Cited by 14
Thyroid Hormone Changes Related to Growth Hormone Therapy in Growth Hormone Deficient Patients
Kucharská, A., Witkowska–Sędek, E., Rumińska, M., & Pyrżak, B. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10225354 · Cited by 12
The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?
List, E. O., Berryman, D. E., Basu, R., Buchman, M., Funk, K. R., Kulkarni, P., Duran‐Ortiz, S., Qian, Y., Jensen, E., Young, J. A., et al. (2020) · Endocrinology · doi:10.1210/endocr/bqaa097 · Cited by 12
Effect of somatotropin and protein supplement on thyroid function of dairy cattle
McClean, C., & Laarveld, B. (1991) · Canadian Journal of Animal Science · doi:10.4141/cjas91-127 · Cited by 11
Effect of Growth Hormone Replacement Therapy on Pituitary Hormone Secretion and Hormone Replacement Therapies in GHD Adults
Hubina, E., Mersebach, H., Rasmussen, Å. K., Juul, A., Sneppen, S. B., Góth, M., & Feldt‐Rasmussen, U. (2004) · Hormone Research in Paediatrics · doi:10.1159/000076538 · Cited by 11
Supra-physiological rhGH administration induces gender-related differences in the hypothalamus–pituitary–thyroid (HPT) axis in healthy individuals
Sgrò, P., Sansone, M., Parisi, A., Sartório, A., Sansone, A., Romanelli, F., Lenzi, A., & Luigi, L. D. (2016) · Journal of Endocrinological Investigation · doi:10.1007/s40618-016-0489-6 · Cited by 9
Pituitary disease mortality: is it fiction?
Erfurth, E. M., Siesjö, P., & Björk‐Eriksson, T. (2013) · Pituitary · doi:10.1007/s11102-013-0469-1 · Cited by 8
Hormonas tiroideas en la reproducción y en la producción láctea del ganado lechero: revisión de literatura
Morales, C. A., & Rodríguez, N. (2016) · Revista Colombiana de Ciencias Pecuarias · doi:10.17533/udea.rccp.324002 · Cited by 7
The effects of recombinant human growth hormone therapy on thyroid function in pediatric patients with growth hormone deficiency
Yao, Q., Zheng, D., Liang, Y., Hou, L., Ying, Y., Luo, X., & Wu, W. (2021) · Translational Pediatrics · doi:10.21037/tp-20-401 · Cited by 7
Characterization of angiotensin II receptors (binding and mRNA) in the rat thyroid gland
Montiel, M., & Jiménez, E. (1998) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0200299 · Cited by 7
Effect of supra-physiological dose administration of rhGH on pituitary-thyroid axis in healthy male athletes
Sgrò, P., Guidetti, L., Crescioli, C., Baldari, C., Romanelli, F., Bianchini, S., D’Armiento, M., Lenzi, A., & Luigi, L. D. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.06.010 · Cited by 6
Octreotide and Bromocriptine Suppress Thyroid Hormone Levels and Thyroid Nodule in an Acromegalic Patient with Nontoxic Autonomous Goiter.
Sakane, N., Yoshida, T., Shimatsu, A., UMEKAWA, T., & Kondo, M. (1997) · Endocrine Journal · doi:10.1507/endocrj.44.305 · Cited by 5
EFFECTS OF GROWTH HORMONE REPLACEMENT THERAPY ON THYROID FUNCTION TESTS IN GROWTH HORMONE DEFICIENT CHILDREN
Moayeri, H., Hemati, A., Bidad, K., & Dalili, H. (2008) · Cited by 4
Correlation between Severity of Growth Hormone Deficiency and Thyroid Metabolism and Effects of Long-Term Growth Hormone Treatment on Thyroid Function in Children with Idiopathic Growth Hormone Deficiency
Ciresi, A., Guarnotta, V., Amato, M. C., & Giordano, C. S. D. S. (2014) · Hormone Research in Paediatrics · doi:10.1159/000356907 · Cited by 4
Peptide Hormones, Metformin and New-Wave Practices and Research Therapies
Graham, M. R., Baker, J. S., & Davies, B. (2016) · Palgrave Macmillan UK eBooks · doi:10.1057/978-1-137-53535-1_11 · Cited by 4
Differential Modulation of Liver and Pituitary Triiodothyronine and 9- cis Retinoid Acid Receptors by Insulin-Like Growth Factor I in Rats
Pellizas, C. G., Montesinos, M. M., Masini-Repiso, A. M., Torres, A. I., & Coleoni, A. H. (2002) · Thyroid · doi:10.1089/105072502321085162 · Cited by 3
Growth Hormone Replacement Causes a Transient Change in Thyroid Function
Soares, D. V., Brasil, R. R. L. O., Spina, L. D. C., da Silva, E. M. C., Lobo, P. M., Buescu, A., o, F. V. L. C. C., & Vaisman, M. (2005) · The Endocrinologist · doi:10.1097/01.ten.0000170842.84948.e5 · Cited by 3
Cognitive Status of Adult Growth Hormone (GH)-Deficient Patients and GH-Induced Neuropsychological Changes
Deijen, J. B., & Arwert, L. I. (2006) · Elsevier eBooks · doi:10.1016/b978-012088484-1/50025-2 · Cited by 2
Impacto do tratamento com GH sobre as funções tireoidiana e adrenal
Martins, M. R. A., & Abucham, J. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000500022 · Cited by 2
Secular changes in growth and maturity
Roche, A. F., & Sun, S. S. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525681.005 · Cited by 2
Measurement and assessment
Roche, A. F., & Sun, S. S. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525681.002 · Cited by 2
Effect of insulin‐like growth factor I on anterior pituitary function
Trainer, P. J. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13318.x · Cited by 2
HYPOTHYROIDISM?
(1990) · The Lancet · doi:10.1016/0140-6736(90)91195-g · Cited by 2
Physiological Effects and Disease Manifestations of Performance-Enhancing Androgenic–Anabolic Steroids, Growth Hormone, and Insulin
Graham, M. R., Baker, J. S., Evans, P., & Davies, B. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195326697.003.0007 · Cited by 1
Farmaci che interferiscono con la funzione tiroidea
Trimarchi, F., & Benvenga, S. (2002) · L Endocrinologo · doi:10.1007/bf03344418 · Cited by 1
Administration of Human Growth Hormone in Critically Ill Patients
Voerman, H. J., & THIJS, L. G. (1993) · Springer eBooks · doi:10.1007/978-3-642-84904-6_15 · Cited by 1
Mild Serum Thyroid Hormone Increase during and after Five-Day Administration of Human Growth Hormone in Healthy Male Adults
Ito, Y., Urae, A., & Okuno, A. (1998) · Endocrine Journal · doi:10.1507/endocrj.45.suppl_s125 · Cited by 1
A Case of Growth Hormone (GH) Deficient Adult with Tertiary Hypothyroidism who Showed Signs of Hyperthyroidism During GH Treatment
Satoh, M., Yoshizawa, A., Tanaka, T., & Hibi, I. (1993) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.2.81 · Cited by 1
Changes in thyroid volume and thyroid function in acromegaly after surgery in Chinese populationPreprint
Shao, Q., Li, J., Gao, L., Guo, X., Wang, Z., Deng, K., Lian, W., & Xing, B. (2019) · Research Square · doi:10.21203/rs.2.14190/v1 · Cited by 1
Thyroid Hormones in Untreated and IGF-I Treated Patients with Laron Syndrome
Laron, Z., & Kauli, R. (2010) · Springer eBooks · doi:10.1007/978-3-642-11183-9_29
Patterns of change in size and body composition
Roche, A. F., & Sun, S. S. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525681.003
Miscellaneous hormones and prostaglandins
Bouillon, R. (1979) · Side effects of drugs annual · doi:10.1016/s0378-6080(79)80049-5
Miscellaneous hormones and prostaglandins
Peters, J. (1994) · Side effects of drugs annual · doi:10.1016/s0378-6080(05)80288-0
Side Effects of Growth Hormone Treatment
Monson, J. P. (1999) · Endocrine updates · doi:10.1007/978-1-4615-5163-8_19
Preface
Roche, A. F., & Sun, S. S. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525681.001
Integrated Interactions of Pituitary Growth Hormone and the Hypothalamic-Pituitary-Thyroid Axis
Diamond, F., & Root, A. W. (1992) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1992.5.3.121
References
(2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525681.007
Significance of human growth
Roche, A. F., & Sun, S. S. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511525681.006
The interaction between growth hormone and the thyroid axis
Behan, L., & Agha, A. (2010)
Potential mechanisms linking nutrition and neuroendocrine control of reproduction in the sheep
Dobbins, A. (2004) · doi:10.33915/etd.2028

Authors: GRUNFELD, C., SHERMAN, B. M., & CAVALIERI, R. R.
Affiliations: San Francisco VA Medical Center (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1988-11
Volume: 67
Issue: 5
Pages: 1111-1114
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-67-5-1111
OpenAlex: W2131223501
Cited by: 108
References: 9
Citations by year: 2026: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI: 2.49
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK37102)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: human growth hormone, thyroid function, thyroid-stimulating hormone, free thyroxine, triiodothyronine, reverse T3, T4 to T3 conversion, normal men
MeSH terms: Adult, Humans, Male, Recombinant Proteins, Growth Hormone, Thyroid Function Tests, Thyroid Gland, Thyrotropin, Thyroxine, Triiodothyronine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Acute Effects of Human Growth Hormone Administration on Thyroid Function in Normal Men*

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks