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Cited by 108Growth Hormone and Insulin-like Growth FactorsThyroid Disorders and TreatmentsHormonal and reproductive studies

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

The Acute Effects of Human Growth Hormone Administration on Thyroid Function in Normal Men*

GRUNFELD, CARL, SHERMAN, BARRY M., CAVALIERI, RALPH R.·1988·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-67-5-1111
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Abstract

GH replacement therapy may lead to alterations in serum TSH and/or thyroid hormone values in GH-deficient patients, but there is no consensus on the explanation for these changes. We examined the effect of GH administration (0.125 mg, sc, daily for 4 days) on thyroid function in 20 normal men. Serum T4 levels decreased by 8%, and serum free T4 index values decreased by 5%. In contrast, serum T3 levels increased by 21%; serum rT3 did not change. These changes were accompanied by a 54% decrease in the mean serum TSH level. While it is not possible to draw conclusions about hormone production and disposal rates from changes in serum levels, these data are most consistent with enhanced extrathyroidal (including intrapituitary) conversion of T4 to T3 and a compensatory decrease in TSH secretion.

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Crossref · 10.1210/jcem-67-5-1111

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9 of 9 references verified0 citation errors · 0 not checkable

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Metadata

Authors
GRUNFELD, C., SHERMAN, B. M., & CAVALIERI, R. R.
Affiliations
San Francisco VA Medical Center (US)
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1988-11
Volume
67
Issue
5
Pages
1111-1114
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-67-5-1111
OpenAlex
W2131223501
Cited by
108
References
9
Citations by year
2026: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
2.49
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK37102)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
human growth hormone, thyroid function, thyroid-stimulating hormone, free thyroxine, triiodothyronine, reverse T3, T4 to T3 conversion, normal men
MeSH terms
Adult, Humans, Male, Recombinant Proteins, Growth Hormone, Thyroid Function Tests, Thyroid Gland, Thyrotropin, Thyroxine, Triiodothyronine

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