Measurement of inhibin concentrations in men: study of changes after castration and comparison with androgen levels in testicular tissue, spermatic venous blood, and peripheral venous blood
Abstract
We measured serum inhibin levels in eight untreated patients with prostatic cancer undergoing castration by RIA using an antiserum against 31-kDa bovine follicular fluid inhibin. The inhibin concentrations in testicular tissue and spermatic venous blood were also measured in six of these patients. Serum inhibin levels (mean +/- SD, 377.8 +/- 212.1 U/L), declined rapidly after castration (15 min after, 233 +/- 171.4; 30 min, 224.6 +/- 156.6; 1 h, 181.5 +/- 95.9; 2 h, 174.3 +/- 69.4; 4 h, 122 +/- 6.4; 6 h, less than 120). High concentrations of inhibin were detected in testicular tissue (31,360 +/- 15,180 U/kg), and the levels in spermatic venous blood (3,178.3 +/- 1,386.8 U/L) were approximately 10 times greater than those in peripheral blood (385.5 +/- 233.1 U/L). Testosterone levels were 1,968.2 +/- 992.3 nmol/kg in testicular tissue and approximately 100 times greater in spermatic venous blood (1,631.6 +/- 389.7 nmol/L) than in peripheral blood (18.0 +/- 4.4 nmol/L). These results suggest that circulating inhibin in men mainly originates from testis and that one of the routes of secretion is via the bloodstream.
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Testicular steroid output is predominantly testosterone, with lower levels of A4 and DHEA also being released into circulation.
“Testicular steroid output is predominantly testosterone, with lower levels of A4 and DHEA also being released into circulation [[51], [52], [53]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [53]
Concentrations of androgen in testicular venous blood of healthy individuals are T (high nanomolar-low micromolar) >> A4, DHEA (medium nanomolar).
“Concentrations of androgen in testicular venous blood of healthy individuals are T (high nanomolar-low micromolar) » A4, DHEA (medium nanomolar) (Hammond et al., 1977, Ishida et al., 1990, Weinstein et al., 1974).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Ishida et al., 1990
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Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works
“Concentrations of androgen in testicular venous blood of healthy individuals are T (high nanomolar-low micromolar) » A4, DHEA (medium nanomolar) (Hammond et al., 1977; Ishida et al., 1990; Weinstein et al., 1974).”
Inhibins, activins and follistatin in reproduction
de Kretser, D. M. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.6.529 · Cited by 211 · see citing works
Self-citation
- Authors
- ISHIDA, H., TASHIRO, H., WATANABE, M., FUJII, N., IMAMURA, K., MINOWADA, S., SHINOHARA, M., FUKUTANI, K., ASO, Y., & DE KRETSER, D. M.
- Affiliations
- SHOWA Medical University (JP)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1990-04
- Volume
- 70
- Issue
- 4
- Pages
- 1019-1022
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2017187756
- Cited by
- 35
- References
- 17
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- inhibin, castration, prostate cancer, testosterone, testicular tissue, peripheral venous blood, androgen levels
- MeSH terms
- Aged, Aged, 80 and over, Androgens, Humans, Inhibins, Male, Orchiectomy, Prostatic Neoplasms, Radioimmunoassay, Spermatic Cord, Testis, Testosterone, Time Factors
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