The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Clonal Origin of Pituitary Adenomas*
Abstract
As the pathogenesis of pituitary adenomas remains unclear, the tumor clonal composition of these common neoplasms was studied. Clonality was determined in female patients by analysis of restriction fragment length polymorphisms of the X-chromosome genes hypoxanthine phosphoribosyl transferase and phosphoglycerate kinase in conjunction with their respective methylation patterns. Peripheral lymphocyte DNA was screened from 62 female patients undergoing transsphenoidal surgery for pituitary adenoma. Eleven patients were heterozygous for the BglI site on PGK, 4 for the BamHI site on HPRT, and 1 patient for both sites. Of these 16 patients, 3 had acromegaly, 4 had Cushing's disease, 7 had hyperprolactinemia, and 2 were clinically nonfunctional. After surgery, morphological study, including immunohistochemistry and electron microscopy of the pathological specimens, allowed a direct comparison between clonality and tumor cell type. Control fresh normal pituitary tissue was found to be polyclonal. The following tumors were monoclonal: all 3 somatotroph adenomas, 4 of 4 lactotroph tumors, 3 of 4 corticotroph cell adenomas, a gonadotroph adenoma, and a nonsecretory adenoma. A mixed plurihormonal adenoma was polyclonal, as were 2 tumors consisting of adenomatous lactotrophs interspersed with nontumorous adenohypophyseal pituitary tissue and one corticotroph adenoma mixed with normal pituitary tissue. Functional pituitary adenomas derived from somatotrophs, corticotrophs, or lactotrophs and nonsecretory tumors are monoclonal in nature, suggesting that somatic cell mutations precede clonal expansion of these cells and play a major role in pituitary tumorigenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Isolation of High‐Molecular‐Weight DNA from Mammalian Cells
Gross‐Bellard, M., Oudet, P., & Chambon, P. (1973) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1973.tb02881.x · Cited by 1,666
DNA METHYLATION AND GENE ACTIVITY
Doerfler, W. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.000521 · Cited by 1,098
FIALKOW, P. (1976) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(76)90003-2 · Cited by 647
Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas
Vallar, L., Spada, A., & Giannattasio, G. (1987) · Nature · doi:10.1038/330566a0 · Cited by 514
Clonal analysis using recombinant DNA probes from the X-chromosome.
Vogelstein, B., Fearon, E. R., Hamilton, S. R., Preisinger, A. C., Willard, H. F., Michelson, A. M., Riggs, A. D., & Orkin, S. H. (1987) · PubMed · Cited by 417
Thorner, M. O., Perryman, R. L., Cronin, M. J., Rogol, A. D., Draznin, M., Johanson, A., Vale, W., Horvath, E., & Kovacs, K. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110708 · Cited by 393
Self-citationClinically nonfunctioning pituitary tumors are monoclonal in origin.
Alexander, J. M., Biller, B. M., Bikkal, H., Zervas, N. T., Arnold, A., & Klibanski, A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114705 · Cited by 366
Thakker, R. V., Bouloux, P., Wooding, C., Chotai, K., Broad, P. M., Spurr, N. K., Besser, G. M., & O'Riordan, J. L. H. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907273210403 · Cited by 334
Clonality of Parathyroid Tumors in Familial Multiple Endocrine Neoplasia Type 1
Friedman, E., Sakaguchi, K., Bale, A. E., Falchetti, A., Streeten, E., Zimering, M. B., Weinstein, L. S., McBride, W. O., Nakamura, Y., Brandi, M.-L., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198907273210402 · Cited by 334
Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro.
Billestrup, N., Swanson, L. W., & Vale, W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.6854 · Cited by 325
Cited by
Dopamine as a Prolactin (PRL) Inhibitor
Ben-Jonathan, N., & Hnasko, R. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.6.0451 · Cited by 983
Pathogenesis of pituitary tumors
Melmed, S. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.40 · Cited by 466
Self-citationThe pathogenesis of pituitary tumours
Asa, S. L., & Ezzat, S. (2002) · Nature Reviews Cancer · doi:10.1038/nrc926 · Cited by 435
Petersenn, S., Fleseriu, M., Casanueva, F. F., Giustina, A., Biermasz, N., Biller, B. M. K., Bronstein, M., Chanson, P., Fukuoka, H., Gadelha, M., et al. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00886-5 · Cited by 411
Self-citationThe Cytogenesis and Pathogenesis of Pituitary Adenomas*
Asa, S. L., & Ezzat, S. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0350 · Cited by 388
Metadata
- Authors
- HERMAN, V., FAGIN, J., GONSKY, R., KOVACS, K., & MELMED, S.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1990-12
- Volume
- 71
- Issue
- 6
- Pages
- 1427-1433
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2082382521
- Cited by
- 560
- References
- 23
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Clonal Origin of Pituitary Adenomas*. https://app.cochat.ai/papers/10.1210/jcem-71-6-1427
- The paper
- HERMAN, V., FAGIN, J., GONSKY, R., KOVACS, K., & MELMED, S. (1990). Clonal Origin of Pituitary Adenomas*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-71-6-1427
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
