The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A New Cause of Female Pseudohermaphroditism: Placental Aromatase Deficiency
Abstract
A description is presented of the first documented case of placental aromatase deficiency. The deficiency caused maternal virilization during pregnancy and pseudohermaphroditism of the female fetus. A 24-yr-old primigravida showed progressive virilization during the third trimester. Urinary excretion of estrogen was less than 14 mumol/day between 35-38 weeks of pregnancy, although nonstress tests showed reactive patterns and serum levels of human placental lactogen were above 460 nmol/L. Maternal serum levels of estrogens were low, and those of androgens were high in the third trimester. A dehydroepiandrosterone sulfate loading test induced a marked increase in maternal serum levels of androgens, whereas no such increase was observed in estrogens. The woman delivered vaginally a live full-term infant who exhibited female pseudohermaphroditism. Cord serum levels of estrogens were extremely low, while those of androgens were high. The aromatase activity of the placenta, determined by the conversion of [7-3H]androstenedione to 17 beta-[7-3H]estradiol and [7-3H]estrone, were less than 0.03 fmol/microgram protein.min (control, 9.6 +/- 2.2 fmol/microgram protein.min). The sulfatase activity of the placenta was 0.63 pmol/microgram protein.min compared to 0.46 +/- 0.16 pmol/microgram protein.min in controls. The rate of aromatization by normal control placentas was the same as that obtained during coincubation of samples of normal placentas and that of the patient. Thus, the presence of aromatase inhibitor in the patient's placenta was excluded.
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Citations
Cites
Studies of prolactin secretion in human pregnancy
Tyson, J. E., Hwang, P., Guyda, H., & Friesen, H. G. (1972) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(72)90446-2 · Cited by 428
WINTER, J. S. D., HUGHES, I. A., REYES, F. I., & FAIMAN, C. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-4-679 · Cited by 365
DE PERETTI, E., & FOREST, M. G. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-5-982 · Cited by 185
Forest, M. G., & Cathiard, A. M. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-5-977 · Cited by 138
A Study of a Pregnancy with Low Estrogen Production Due to Placental Sulfatase Deficiency
France, J. T., Seddon, R. J., & Liggins, G. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-1-1 · Cited by 107
Testosterone and dihydrotestosterone in maternal and cord blood and in amniotic fluid
Dawood, M. Y., & Saxena, B. B. (1977) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(77)90815-8 · Cited by 87
PLACENTAL METABOLISM OF DEHYDROEPIANDROSTERONE SULPHATE IN NORMAL PREGNANCY
Klopper, A. I., Varela‐Torres, R., & Jandial, V. (1976) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1976.tb00869.x · Cited by 28
Four cases of pregnancy with low estrogen production due to placental enzymatic deficiency
Mango, D., MONTEMURRO, A., Scirpa, P., Bompiani, A., & Menini, E. (1978) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(78)90129-6 · Cited by 19
Cited by
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
Smith, E. P., Boyd, J., Frank, G. R., Takahashi, H., Cohen, R. M., Specker, B., Williams, T. C., Lubahn, D. B., & Korach, K. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311604 · Cited by 2,471
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*
SIMPSON, E. R., MAHENDROO, M. S., MEANS, G. D., KILGORE, M. W., HINSHELWOOD, M. M., GRAHAM-LORENCE, S., AMARNEH, B., ITO, Y., FISHER, C. R., MICHAEL, M. D., et al. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-342 · Cited by 1,537
Morishima, A., Grumbach, M. M., Simpson, E. R., Fisher, C., & Qin, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530621 · Cited by 1,416
Effect of testosterone and estradiol in a man with aromatase deficiency
Carani, C., Qin, K., Simoni, M., Faustini-Fustini, M., Serpente, S., Boyd, J., Korach, K. S., & Simpson, E. R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370204 · Cited by 1,151
Metadata
- Authors
- SHOZU, M., AKASOFU, K., HARADA, T., & KUBOTA, Y.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1991-03
- Volume
- 72
- Issue
- 3
- Pages
- 560-566
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2023041684
- Cited by
- 288
- References
- 8
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- SHOZU, M., AKASOFU, K., HARADA, T., & KUBOTA, Y. (1991). A New Cause of Female Pseudohermaphroditism: Placental Aromatase Deficiency. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-72-3-560
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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