The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The effects of exogenous testosterone on sexuality and mood of normal men.
Abstract
The effects of supraphysiological levels of testosterone, used for male contraception, on sexual behavior and mood were studied in a single-blind, placebo-controlled manner in a group of 31 normal men. After 4 weeks of baseline observations, the men were randomized into two groups: one group received 200 mg testosterone enanthate (TE) weekly by im injection for 8 weeks (Testosterone Only group), the other received placebo injections once weekly for the first 4 weeks followed by TE 200 mg weekly for the following 4 weeks (Placebo/Testosterone group). The testosterone administration increased trough plasma testosterone levels by 80%, compatible with peak testosterone levels 400-500% above baseline. Various aspects of sexuality were assessed using sexuality experience scales (SES) questionnaires at the end of each 4-week period while sexual activity and mood states were recorded by daily dairies and self-rating scales. In both groups there was a significant increase in scores in the Psychosexual Stimulation Scale of the SES (i.e. SES 2) following testosterone administration, but not with placebo. There were no changes in SES 3, which measures aspects of sexual interaction with the partner. In both groups there were no changes in frequency of sexual intercourse, masturbation, or penile erection on waking nor in any of the moods reported. The Placebo/Testosterone group showed an increase in self-reported interest in sex during testosterone treatment but not with placebo. The SES 2 results suggest that sexual awareness and arousability can be increased by supraphysiological levels of testosterone. However, these changes are not reflected in modifications of overt sexual behavior, which in eugonadal men may be more determined by sexual relationship factors. This contrasts with hypogonadal men, in whom testosterone replacement clearly stimulates sexual behavior. There was no evidence to suggest an alteration in any of the mood states studied, in particular those associated with increased aggression. We conclude that supraphysiological levels of testosterone maintained for up to 2 months can promote some aspects of sexual arousability without stimulating sexual activity in eugonadal men within stable heterosexual relationships. Raising testosterone does not increase self-reported ratings of aggressive feelings.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Anderson et al. (1992), using weekly injections of either placebo or testosterone enanthate (200 mg) over 8 weeks, found no effect of the exogenous testosterone on sexual activity, either with a partner or as masturbation, but a significant increase in a measure of sexual interest independent of sexual interaction with the partner.”
From The endocrinology of sexual arousal (2005) · cites this paper as Anderson et al. (1992)
Citations
Cites
The influence of testosterone on human aggression
Archer, J. E. (1991) · British Journal of Psychology · doi:10.1111/j.2044-8295.1991.tb02379.x · Cited by 656
Plasma Testosterone, Dominance Rank and Aggressive Behaviour in Male Rhesus Monkeys
Rose, R. M., Holaday, J. W., & Bernstein, I. S. (1971) · Nature · doi:10.1038/231366a0 · Cited by 389
Hormones, Emotional Dispositions, and Aggressive Attributes in Young Adolescents
Susman, E. J., Inoff‐Germain, G., Nottelmann, E. D., Loriaux, D. L., Cutler, G. B., & Chrousos, G. P. (1987) · Child Development · doi:10.1111/j.1467-8624.1987.tb01445.x · Cited by 362
Skakkebæk, N. E., Bancroft, J., DAVIDSON, D. W., & Warner, P. (1981) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1981.tb00364.x · Cited by 335
Self-citationChanges in erectile responsiveness during androgen replacement therapy
Bancroft, J., & Wu, F. C. W. (1983) · Archives of Sexual Behavior · doi:10.1007/bf01542116 · Cited by 288
Self-citationA radioimmunoassay for testosterone in various biological fluids without chromatography
Corker, C. S., & Davidson, D. W. (1978) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(78)90634-9 · Cited by 199
Testosterone Therapy for Low Sexual Interest and Erectile Dysfunction in Men: a Controlled Study
O'Carroll, R., & Bancroft, J. (1984) · British Journal of Psychiatry · doi:10.1192/bjp.145.2.146 · Cited by 188
Self-citationO’Carroll, R. E., Shapiro, C. M., & Bancroft, J. (1985) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1985.tb01113.x · Cited by 178
Self-citationSerum Testosterone and Aggressiveness in Hockey Players
Scaramella, T. J., & Brown, W. A. (1978) · Psychosomatic Medicine · doi:10.1097/00006842-197805000-00007 · Cited by 115
SPECIAL ARTICLE Androgens: Risks and Benefits
Bardin, C. W., Swerdloff, R. S., & Santen, R. J. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-1-4 · Cited by 113
Cited by
Sorted by citations
Items 201–239 of 239
Sexual side effects of oral contraceptives: clinical considerations.
Graham, C. A. (2002) · ePrints Soton (University of Southampton)
Genetic dissection of sex differences in human brain and behaviour
Tan, G. C.-Y. (2011) · UCL Discovery (University College London)
Androgen Treatment of the Hypogonadal Male
Matsumoto, A. M. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-388-0_16
Facteurs culturels psychosociaux façonnant les attitudes envers la pilule contraceptiwe masculine
van Wersch, A., Eberhardt, J., & Stringer, F. (2013) · Springer eBooks · doi:10.1007/978-2-8178-0346-3_11
Sexual Counterpart of Hormonal Male Contraception
Meriggiola, M. C., Constantino, A., & Cerpolini, S. (2011) · doi:10.1002/9781119963820.ch10
Anatomie, Physiologie, Pathophysiologie
Schmidt, P., Jünemann, K.-P., Derouet, H., Jost, W. H., Ückert, S., Popken, G., Wetterauer, U., Behre, H. M., Hartmann, U. H., & Thon, W. (1999) · Springer eBooks · doi:10.1007/978-3-642-98009-1_2
Testosterone and vasopressin in men's reproductive behavior
Steiner, E. T. (2020) · Digital Scholarship - UNLV (University of Nevada Reno) · doi:10.34917/2269036 · Cited by 1
Libidoverlies bij gebruik van de pil
Wijs, M. F.-D., & van Dijk, E. (2007) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-6369-8_17
Prophylactics of Erectile Dysfunction in Patients with Metabolic Syndrome
Gamidov, S. I., Мазо, Е. Б., Rv, G., & Sotnikova, E. M. (2009) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-009-0690-0
Male hormonal contraception: a safe option?
Walton, M. J., & Anderson, R. A. (2006) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.1.1.25
Self-citationTestosterone and Mood in Aging Men
Seidman, S. N., & Orr, G. (2006) · Aging Health · doi:10.2217/1745509x.2.1.61
Effets secondaires des androgènes
Mowszowicz, I. (1995) · Andrologie · doi:10.1007/bf03034339
Howe, R. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105173442016
Vieillissement et fertilité de l'homme
Vermeulen, A., & Belaisch, J. (1997) · Andrologie · doi:10.1007/bf03034934
Endocrine Disruptors and Male Sexual Dysfunction
Sikka, S. C., Kendirci, M., & Naz, R. (2004) · CRC Press eBooks · doi:10.1201/9781420038866.ch11 · Cited by 1
Haren, M. T. (2005) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Hyperactive sexual desire and the paraphilias
Ågmo, A. (2007) · Elsevier eBooks · doi:10.1016/b978-012370590-7/50013-x
Hormonal Evaluation and Therapy of Erectile Dysfunction
Hockenberry, M. S., & Masson, P. (2016) · Springer eBooks · doi:10.1007/978-3-319-31587-4_7
Effets secondaires des androg nes
Mowszowicz, I. (1995)
Obstructive sleep apnoea and sexual function in men
Melehan, K. L. (2014) · The Sydney eScholarship Repository (The University of Sydney)
van Wersch, A., Eberhardt, J., & Stringer, F. (2012)
Bonson, K. R., & Baggott, M. J. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-165-7_9
(2007) · CRC Press eBooks · doi:10.3109/9781420015089-8
Hirshkowitz, M., Orengo, C. A., & Cunningham, G. R. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-700-0_17
Bradford, A. M., & Meston, C. M. (2014) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199328710.013.030
Handelsman, D. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00142-8
(2007) · CRC Press eBooks · doi:10.3109/9781420015089-7
Faculty Opinions recommendation of Treatment of men for "low testosterone": A systematic review.
Minhas, S., Tharakan, T., & Miah, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726764636.793556540
Libidoverlies bij gebruik van de pil
Wijs, M. F.-D., & van Dijk, E. (2004) · Huisarts en Wetenschap · doi:10.1007/bf03083794
Aprendiendo Sobre Sexualidad: Una Manera Practica de Comenzar
Zeidenstein, S., & Moore, K. (1999) · doi:10.31899/pgy1999.1003
Testosterone and male sexual function
Huhtaniemi, I. T. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13432-6.00013-7
Ossa, A. B., Cañas, J. M. H., Osorio, J. M. M., & Gómez-Gutiérrez, M. (2024) · Revista Urología Colombiana / Colombian Urology Journal · doi:10.24875/ruc.23000101
Hirshkowitz, M., Orengo, C. A., & Cunningham, G. R. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-375-0_20
Testosterone and Sexual Function
Hsiao, W., & Mulhall, J. P. (2012) · Springer eBooks · doi:10.1007/978-1-4471-4405-2_4
Kintz, P., & Gheddar, L. (2026) · Journal of Analytical Toxicology · doi:10.1093/jat/bkag082
Birgner, C. (2008) · Uppsala University Publications (Uppsala University)
Metadata
- Authors
- Anderson, R. A., Bancroft, J., & Wu, F. C.
- Affiliations
- Medical Research Council (GB)
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1992-12
- Volume
- 75
- Issue
- 6
- Pages
- 1503-1507
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1969403521
- Cited by
- 238
- References
- 15
- Citations by year
- 2026: 1 · 2024: 4 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 6 · 2013: 4 · 2012: 5
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- testosterone, testosterone enanthate, male contraception, sexual behavior, sexual arousal, mood, aggression, eugonadal men, sexual desire, plasma testosterone, testosterone replacement therapy
- MeSH terms
- Adult, Affect, Humans, Male, Surveys and Questionnaires, Reference Values, Sexual Behavior, Testosterone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
