Diurnal variation of cerebrospinal fluid immunoreactive corticotropin-releasing hormone levels in healthy volunteers.

Kling, M A; DeBellis, M D; O'Rourke, D K; Listwak, S J; Geracioti, T D; McCutcheon, I E; Kalogeras, K T; Oldfield, E H; Gold, P W

doi:10.1210/jcem.79.1.8027234

Cited by 45Stress Responses and CortisolNeuropeptides and Animal PhysiologyCircadian rhythm and melatonin

Diurnal variation of cerebrospinal fluid immunoreactive corticotropin-releasing hormone levels in healthy volunteers.

Kling, M A, DeBellis, M D, O'Rourke, D K, Listwak, S J, Geracioti, T D, McCutcheon, I E, Kalogeras, K T, Oldfield, E H +1 more·1994·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.79.1.8027234

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Abstract

CRH is not only secreted into hypophyseal protal blood where it is believed to regulate the circadian rhythm of pituitary-adrenal activity, but is also measurable in cerebrospinal fluid (CSF). Altered CSF immunoreactive CRH (IR-CRH) levels have been found in patients with a number of neuropsychiatric disorders and have been implicated in some of the symptoms of these disorders. To further study the potential functional relevance of CRH in human CSF, we examined whether a nonuniform temporal pattern of IR-CRH levels existed in CSF using hourly sampling over a 30-h period in six healthy volunteers. CSF was withdrawn continuously at 6 mL/h through a catheter placed in the lumbar subarachnoid space and connected to a miniroller pump and fraction collector. A significant diurnal variation in CSF IR-CRH levels was observed (P < 0.001), with highest levels between 1830-2330 h and lowest levels around 0730 h. This pattern was nearly opposite that of plasma cortisol levels, which showed the expected peak around 0800 h and nadir around 2000-2200 h. In addition, CSF IR-CRH levels in three of the six volunteers showed significant negative correlations with simultaneous plasma cortisol levels. These data suggest that CSF IR-CRH concentrations are negatively modulated by peripheral cortisol secretion, which may be one factor involved in the entrainment of this rhythm. Although the functional significance of this diurnal variation in CSF IR-CRH levels is unknown, the presence of a distinct…

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CRF shows an evening acrophase and morning nadir in cerebrospinal fluid.
“shows an evening acrophase and morning nadir in cerebrospinal fluid (Kling et al., 1994).”
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Diurnal rhythm of plasma immunoreactive corticotropin-releasing factor in normal subjects
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The Diurnal Variation of Immunoreactive Thyrotropin-Releasing Hormone and Somatostatin in the Cerebrospinal Fluid of the Rhesus Monkey*
Berelowitz, M., Perlow, M. J., Hoffman, H. J., & Frohman, L. A. (1981) · Endocrinology · doi:10.1210/endo-109-6-2102 · Cited by 50 · see citing works

Authors: Kling, M. A., DeBellis, M. D., O'Rourke, D. K., Listwak, S. J., Geracioti, T. D., McCutcheon, I. E., Kalogeras, K. T., Oldfield, E. H., & Gold, P. W.
Affiliations: National Institutes of Health (US)
ORCID: Kling, M A
McCutcheon, I E
Gold, P W
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1994-07
Volume: 79
Issue: 1
Pages: 233-239
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.79.1.8027234
OpenAlex: W2048798561
Cited by: 45
References: 22
Citations by year: 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 3
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: corticotropin-releasing factor, cerebrospinal fluid, diurnal variation, circadian rhythm, plasma cortisol, pituitary-adrenal axis, healthy volunteers, CSF sampling
MeSH terms: Adult, Circadian Rhythm, Corticotropin-Releasing Hormone, Female, Humans, Hydrocortisone, Male, Reference Values, Sex Characteristics

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Diurnal variation of cerebrospinal fluid immunoreactive corticotropin-releasing hormone levels in healthy volunteers.

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