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Cited by 137Diabetes Management and ResearchDiabetes Management and EducationDiabetes Treatment and Management

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Frequency of severe hypoglycemia in insulin-dependent diabetes mellitus can be predicted from self-monitoring blood glucose data.

Cox, D J, Kovatchev, B P, Julian, D M, Gonder-Frederick, L A, Polonsky, W H, Schlundt, D G, Clarke, W L·1994·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.79.6.7989471
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Abstract

Severe hypoglycemia is associated with insulin-dependent diabetes mellitus and may occur more frequently as metabolic control approaches normal. The goal of this study was to determine whether the frequency of severe hypoglycemia could be predicted by the following predictor variables: 1) frequency and degree of low blood glucose (BG) readings, 2) degree of BG variability during routine self-monitoring blood glucose (SMBG) readings, and 3) level of glycemic control measured by glycosylated hemoglobin-A1 (HbA1). Seventy-eight insulin-dependent diabetes mellitus subjects from 3 different sites had their glycosylated HbA1 assayed and then performed 50 SMBG recordings during the next 2-3 weeks. Over the following 6 months, subjects recorded their severe hypoglycemic episodes (stupor or unconsciousness). There was no difference in the number of severe hypoglycemic episodes between subjects in good vs. poor metabolic control. A higher frequency of severe hypoglycemia during the subsequent 6 months was predicted by frequent and extreme low SMBG readings and variability in day to day SMBG readings. Regression analysis indicated that 44% of the variance in severe hypoglycemic episodes could be accounted for by initial measures of BG variance and the extent of low BG readings. Patients who recorded variable and frequent very low BG readings during routine SMBG were at higher risk for subsequent severe hypoglycemia. Individuals who had lower glycosylated Hb levels were not at higher risk of severe hypoglycemic episodes.

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Crossref · 10.1210/jcem.79.6.7989471

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Metadata

Authors
Cox, D. J., Kovatchev, B. P., Julian, D. M., Gonder-Frederick, L. A., Polonsky, W. H., Schlundt, D. G., & Clarke, W. L.
Affiliations
University of Virginia (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1994-12
Volume
79
Issue
6
Pages
1659-1662
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.79.6.7989471
OpenAlex
W2101481281
Cited by
137
References
12
Citations by year
2024: 3 · 2023: 4 · 2022: 10 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 10 · 2017: 7 · 2016: 3 · 2015: 11 · 2014: 6 · 2013: 6 · 2012: 4
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dk028288-27)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK28288)
  • National Center for Research Resources (M01RR000847, M01-RR 00847)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
severe hypoglycemia, type 1 diabetes, self-monitoring of blood glucose, blood glucose variability, HbA1c, glycemic control, hypoglycemia risk prediction
MeSH terms
Adult, Blood Glucose, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Humans, Hypoglycemia, Male, Regression Analysis, Risk Factors, Blood Glucose Self-Monitoring

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