Long-term follow-up evaluation of blood glucose awareness training
Abstract
OBJECTIVE: Blood glucose awareness training (BGAT) has been found effective in teaching individuals with insulin-requiring diabetes to improve their ability to better recognize blood glucose (BG) fluctuations. This study investigated whether subjects who underwent BGAT a mean of 4.9 years previously were superior to past control subjects in terms of their ability to recognize BG fluctuations, and whether past BGAT subjects had fewer automobile crashes and lost work days and better glycosylated hemoglobin than control subjects. Additionally, the beneficial effects of providing booster training to past BGAT subjects also was evaluated. RESEARCH DESIGN AND METHODS: This study followed up 28 past BGAT subjects. Half of these subjects (n = 14) received a simple booster-training program. Twelve previous control subjects also were evaluated. Booster subjects were given a BGAT diary to complete for 2 weeks before evaluation. Evaluation for all subjects included completion of a retrospective questionnaire on work and driving history, blood drawing for a glycosylated hemoglobin analysis, and having subjects estimate and measure their BG levels 50-80 times during a 3- to 4-week period during their daily routine. RESULTS: At long-term follow-up, BGAT subjects had significantly fewer automobile crashes than control subjects. BGAT subjects receiving booster training were significantly more accurate at estimating their BG levels and were more aware of hypoglycemia. Post hoc analyses indicated that the ability to accurately estimate BG fluctuations correlated positively with follow-up glycosylated hemoglobin and the number of hypoglycemic and hyperglycemic symptoms participants demonstrated. Both BGAT and control subjects demonstrated significantly improved glycosylated hemoglobin relative to baseline measures. CONCLUSIONS: These data suggest that BGAT has long-term benefits, which can be enhanced with booster training. Specifically, BGAT and simple booster training may result in reduction of severe hypoglycemic episodes and automobile crashes in the long term.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Teaching people with diabetes to balance insulin use and carbohydrate intake and physical activity are necessary, but these strategies are not always sufficient for prevention.
“Teaching people with diabetes to balance insulin use and carbohydrate intake and physical activity are necessary, but these strategies are not always sufficient for prevention (77,(103)(104)(105).”
From 6. Glycemic Targets: <i>Standards of Care in Diabetes—2023</i> (2023) · cites this paper as [105]
Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667 · see citing works
Langan, S. J., Deary, I. J., Hepburn, D. A., & Frier, B. M. (1991) · Diabetologia · doi:10.1007/bf00405006 · Cited by 234 · see citing works
Permanent neuropsychological impairment after recurrent episodes of severe hypoglycaemia in man
Wredling, R., Levander, S. E., Adamson, U., & Lins, P. E. (1990) · Diabetologia · doi:10.1007/bf00404042 · Cited by 159 · see citing works
Driving decrements in type I diabetes during moderate hypoglycemia
Cox, D. J., Gonder-Frederick, L., & Clarke, W. (1993) · Diabetes · doi:10.2337/diab.42.2.239 · Cited by 123 · see citing works
Self-citationLongitudinal Relationship of Asymptomatic Hypoglycemia to Cognitive Function in IDDM
Golden, M. P., Ingersoll, G. M., Brack, C. J., Russell, B. A., Wright, J. C., & Huberty, T. J. (1989) · Diabetes Care · doi:10.2337/diacare.12.2.89 · Cited by 104 · see citing works
Perceived Symptoms in the Recognition of Hypoglycemia
Cox, D. J., Gonder-Frederick, L. A., Antoun, B., Cryer, P. E., & Clarke, W. L. (1993) · Diabetes Care · doi:10.2337/diacare.16.2.519 · Cited by 97 · see citing works
Self-citationSevere Hypoglycemia in IDDM Children
Bergadá, I., Suissa, S., Dufresne, J., & Schiffrin, A. (1989) · Diabetes Care · doi:10.2337/diacare.12.4.239 · Cited by 74 · see citing works
Cox, D. J., Gonder-Frederick, L. A., Julian, D. M., Cryer, P., Lee, J. H., Richards, F. E., & Clarke, W. L. (1991) · Psychosomatic Medicine · doi:10.1097/00006842-199107000-00010 · Cited by 51 · see citing works
Self-citationEnhancing Blood Glucose Awareness in Adolescents and Young Adults With IDDM
Nurick, M. A., & Johnson, S. B. (1991) · Diabetes Care · doi:10.2337/diacare.14.1.1 · Cited by 50 · see citing works
Effects and Correlates of Blood Glucose Awareness Training Among Patients With IDDM
Cox, D. J., Gonder-Frederick, L. A., Lee, J. H., Julian, D. M., Carter, W. R., & Clarke, W. L. (1989) · Diabetes Care · doi:10.2337/diacare.12.5.313 · Cited by 40 · see citing works
Self-citationBlood glucose discrimination training in insulin-dependent diabetes mellitus (IDDM) patients
Cox, D. J., Carter, W. R., Gonder-Frederick, L. A., Clarke, W. L., & Pohl, S. L. (1988) · Applied Psychophysiology and Biofeedback · doi:10.1007/bf00999170 · Cited by 31 · see citing works
Self-citationClarification of Error-Grid Analysis
Cox, D. J., Richards, F. E., Gonder-Frederick, L. A., et al. (1989) · Diabetes Care · doi:10.2337/diacare.12.3.235 · Cited by 22 · see citing works
Self-citationBlood glucose discrimination training and metabolic control in insulin-dependent diabetics
Gross, A. M., Magalnick, L. J., & Delcher, H. K. (1985) · Behaviour Research and Therapy · doi:10.1016/0005-7967(85)90097-x · Cited by 11 · see citing works
Blood Glucose Discrimination in Insulin-Dependent Diabetics
Roales-Nieto, J. G. (1988) · Behavior Modification · doi:10.1177/01454455880121006 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The summary of diabetes self-care activities measure: results from 7 studies and a revised scale.
Toobert, D. J., Hampson, S. E., & Glasgow, R. E. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.943 · Cited by 2,561 · see citing works
6. Glycemic Targets: <i>Standards of Medical Care in Diabetes—2022</i>
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s006 · Cited by 1,403 · see citing works
Management of diabetes and hyperglycemia in hospitals.
Clement, S., Braithwaite, S. S., Magee, M. F., Ahmann, A., Smith, E. P., Schafer, R. G., Hirsch, I. B., & on behalf of the Diabetes in Hospitals Writing Committee (2004) · Diabetes Care · doi:10.2337/diacare.27.2.553 · Cited by 1,266 · see citing works
England, J. D., Gronseth, G. S., Franklin, G., Miller, R. G., Asbury, A. K., Carter, G. T., Cohen, J. A., Fisher, M. A., Howard, J. F., Kinsella, L. J., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000149522.32823.ea · Cited by 742 · see citing works
6. Glycemic Targets: <i>Standards of Care in Diabetes—2023</i>
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D., Johnson, E. L., et al. (2023) · Diabetes Care · doi:10.2337/dc23-s006 · Cited by 684 · see citing works
Clarke, W. L., Cox, D. J., Gonder-Frederick, L. A., Julian, D., Schlundt, D., & Polonsky, W. (1995) · Diabetes Care · doi:10.2337/diacare.18.4.517 · Cited by 651 · see citing works
Self-citationBlood Glucose Awareness Training (BGAT-2)
Cox, D. J., Gonder-Frederick, L., Polonsky, W., Schlundt, D., Kovatchev, B., & Clarke, W. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.637 · Cited by 235 · see citing works
Self-citationYeoh, E., Choudhary, P., Nwokolo, M., Ayis, S., & Amiel, S. A. (2015) · Diabetes Care · doi:10.2337/dc15-0102 · Cited by 154 · see citing works
Cox, D. J., Kovatchev, B. P., Julian, D. M., Gonder-Frederick, L. A., Polonsky, W. H., Schlundt, D. G., & Clarke, W. L. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.6.7989471 · Cited by 137 · see citing works
Self-citationSmith, C. B., Choudhary, P., Pernet, A., Hopkins, D., & Amiel, S. A. (2009) · Diabetes Care · doi:10.2337/dc08-2259 · Cited by 106 · see citing works
Cox, D. J., Kovatchev, B., Kovatchev, B., Koev, D., Koeva, L., Dachev, S., Tcharaktchiev, D., Protopopova, A., Gonder-Frederick, L., & Clarke, W. (2004) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm1104_4 · Cited by 88 · see citing works
Self-citationSchachinger, H., Hegar, K., Hermanns, N., Straumann, M., Keller, U., Fehm-Wolfsdorf, G., Berger, W., & Cox, D. (2005) · Journal of Behavioral Medicine · doi:10.1007/s10865-005-9026-3 · Cited by 73 · see citing works
Self-citationLucidi, P., Porcellati, F., Bolli, G. B., & Fanelli, C. G. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1065-6 · Cited by 38 · see citing works
Clinical approaches to treat impaired awareness of hypoglycaemia
Farrell, C. M., & McCrimmon, R. J. (2021) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188211000248 · Cited by 31 · see citing works
- Authors
- Cox, D. J., Gonder-Frederick, L., Julian, D. M., & Clarke, W.
- Affiliations
- University of Virginia Health System (US)
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 1994-01-01
- Volume
- 17
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2034771594
- Cited by
- 143
- References
- 14
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 9 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk028288-27)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK28288)
- National Center for Research Resources (RR 00847, M01RR000847)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
- Keywords
- type 1 diabetes, hypoglycemia awareness, blood glucose estimation, booster training, HbA1c, automobile crashes, absenteeism, long-term follow-up, diabetes self-management
- MeSH terms
- Acute Disease, Chronic Disease, Delivery of Health Care, Diabetes Mellitus, Humans, Models, Theoretical, United States
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review