Hyperinsulinemic hypoglycemia of infancy (nesidioblastosis) in clinical remission: high incidence of diabetes mellitus and persistent beta-cell dysfunction at long-term follow-up
Open accessAbstract
In persistent hyperinsulinemic hypoglycemia of infancy (PHHI), the long term outcome of the disease is not well documented. Previous reports suggested that partial pancreatectomy in infants does not endanger future islet function. We evaluated endocrine pancreatic function in 14 PHHI patients 6.5-21 yr after diagnosis. Eight underwent early subtotal pancreatectomy, and 6 were medically treated; all were in clinical remission. Intravenous glucose tolerance and C-peptide suppression tests were performed, with multiple determinations of hormone levels. The insulin response to glucose was blunted in all pancreatectomized and in 2 conservatively treated patients. Glucose disposal was reduced in 6 pancreatectomized patients and in 2 medically treated subjects. Six of the pancreatectomized patients, including two with normal glucose disposal at first evaluation, developed overt diabetes during puberty. None in the medically treated group became diabetic; however, only 2 patients have reached puberty. C-Peptide suppression in response to hypoglycemia was inadequate in 4 of 5 pancreatectomized and 3 of 5 nonpancreatectomized patients studied. These results show that children with PHHI have impaired insulin responses to glucose and lack of suppressibility of endogenous insulin secretion several years after clinical remission. Thus, the beta-cell defect responsible for the disease in infancy is not corrected with time despite the disappearance of spontaneous hypoglycemia. Insulin secret…
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A low-carbohydrate diet or α-glucosidase inhibitors are not effective in most patients with NIPHS.
“While a low carbohydrate diet or α -glucosidase inhibitors are not effective in most patients, the potassium channel activator diazoxide has been shown to alleviate symptoms in some cases [58,59].”
The potassium channel activator diazoxide has been shown to alleviate symptoms in some cases of NIPHS.
“While a low carbohydrate diet or α -glucosidase inhibitors are not effective in most patients, the potassium channel activator diazoxide has been shown to alleviate symptoms in some cases [58,59].”
Cites
Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.
Bonner‐Weir, S., Trent, D. F., & Weir, G. C. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110910 · Cited by 462 · see citing works
Amiel, S. A., Tamborlane, W. V., Simonson, D. C., & Sherwin, R. S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198705283162205 · Cited by 309 · see citing works
Effects of Hemipancreatectomy on Insulin Secretion and Glucose Tolerance in Healthy Humans
Kendall, D. M., Sutherland, D. E. R., Najarian, J. S., Goetz, F. C., & Robertson, R. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003293221305 · Cited by 244 · see citing works
Reversibility of unawareness of hypoglycemia in patients with insulinomas.
Mitrakou, A., Fanelli, C., Veneman, T., Perriello, G., Calderone, S., Platanisiotis, D., Rambotti, A., Raptis, S., Brunetti, P., Cryer, P., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199309163291203 · Cited by 221 · see citing works
Aynsley-Green, A., Polak, J. M., Bloom, S. R., Gough, M., Keeling, J. W., Ashcroft, S. J. H., Turner, R. C., & Baum, J. D. (1981) · Archives of Disease in Childhood · doi:10.1136/adc.56.7.496 · Cited by 207 · see citing works
Gläser, B., Hirsch, H. J., & Landau, H. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80970-9 · Cited by 160 · see citing works
Self-citationShort- and long-term use of octreotide in the treatment of congenital hyperinsulinism
Thorton, P. S., & Alter, C. A. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80969-2 · Cited by 159 · see citing works
Hyperinsulinism in Infants and Children: Diagnosis and Therapy*
Stanley, C. A., & Baker, L. (1976) · Advances in Pediatrics · doi:10.1016/s0065-3101(22)00724-1 · Cited by 125 · see citing works
Nesidioblastosis and endocrine hyperplasia of the pancreas: A secondary phenomenon
Goudswaard, W. B., Houthoff, H. J., Koudstaal, J., & Zwierstra, R. P. (1986) · Human Pathology · doi:10.1016/s0046-8177(86)80154-x · Cited by 70 · see citing works
Persistent Neonatal Hypoglycemia Due to Hyperinsulinism: Medical Aspects
Landau, H., Perlman, M., Meyer, S., Isacsohn, M., Krausz, M., Mayan, H., Lijovetzky, G., & Schiller, M. (1982) · PEDIATRICS · doi:10.1542/peds.70.3.440 · Cited by 59 · see citing works
Self-citationFamilial nesidioblastosis: Severe neonatal hypoglycemia in two families
Schwartz, S. S., Rich, B. H., Lucky, A. W., Straus, F. H., Gonen, B., Wolfsdorf, J. I., Thorp, F. W., Burrington, J. D., Madden, J. D., Rubenstein, A. H., et al. (1979) · The Journal of Pediatrics · doi:10.1016/s0022-3476(79)80080-3 · Cited by 58 · see citing works
Gläser, B., Landau, H., And, A. S., & Nesher, R. (1989) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1989.tb00455.x · Cited by 53 · see citing works
Self-citationLong-term treatment with diazoxide in childhood hyperinsulinism
Grant, D., Dunger, D. B., & Burns, E. C. (1986) · European Journal of Endocrinology · doi:10.1530/acta.0.112s340 · Cited by 42 · see citing works
Gläser, B., Phillip, M., Carmi, R., Lieberman, E., & Landau, H. (1990) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320370416 · Cited by 42 · see citing works
Self-citationDecrease of Pancreatic Somatostatin in Neonatal Nesidiobiastosis
Bishop, A. E., Polak, J. M., Chesa, P. G., Timson, C. M., Bryant, M. G., & Bloom, S. R. (1981) · Diabetes · doi:10.2337/diab.30.2.122 · Cited by 39 · see citing works
The surgical treatment of hyperinsulinism in infancy and childhood
Gough, M. (1984) · British journal of surgery · doi:10.1002/bjs.1800710125 · Cited by 38 · see citing works
Nesidioblastosis: evidence for autosomal recessive inheritance.
Woolf, D. A., Leonard, J. V., Trembath, R. C., Pembrey, M. E., & Grant, D. (1991) · Archives of Disease in Childhood · doi:10.1136/adc.66.4.529 · Cited by 37 · see citing works
Familial hyperinsulinism: Successful conservative management
Horev, Z., Ipp, M., Levey, P., & Daneman, D. (1991) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80285-9 · Cited by 35 · see citing works
Long-term treatment of refractory neonatal hypoglycemia with long-acting somatostatin analog
Jackson, J. A., Hahn, H. B., Oltorf, C. E., O’Dorisio, T. M., & VINIK, A. I. (1987) · The Journal of Pediatrics · doi:10.1016/s0022-3476(87)80118-x · Cited by 35 · see citing works
RECENT PROGRESS IN PEDIATRIC ENDOCRINOLOGY
Levine, L. S. (1979) · Pediatric Annals · doi:10.3928/0090-4481-19790701-10 · Cited by 34 · see citing works
Kaiser, Ν., Corcos, A. P., Tur-Sinai, A., Ariav, Y., Gläser, B., Landau, H., & Cerasi, E. (1990) · Diabetologia · doi:10.1007/bf00405110 · Cited by 31 · see citing works
Self-citationPancreatic growth and function following surgical treatment of nesidioblastosis in infancy
Schönaü, E., Deeg, K. H., Huemmer, H. P., Akcetin, Y. Z., & Böhles, H. J. (1991) · European Journal of Pediatrics · doi:10.1007/bf02072204 · Cited by 29 · see citing works
The occurrence of low insulin response to glucose infusion in children
Cerasi, E., & Luft, R. (1970) · Diabetologia · doi:10.1007/bf00421434 · Cited by 26 · see citing works
Self-citationPancreatic exocrine and endocrine function after subtotalpancreatectomy for nesidioblastosis
Dunger, D. B., Burns, C., Ghale, G. K., Muller, D. P. R., Spitz, L., & Grant, D. (1988) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(88)80136-2 · Cited by 25 · see citing works
The enigma of persistent hyperinsulinemic hypoglycemia of infancy
Daneman, D., & Ehrlich, R. M. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)80952-7 · Cited by 22 · see citing works
The surgical management of hyperinsulinism in infancy due to nesidioblastosis
Warden, M. J., German, J. C., & Buckingham, B. A. (1988) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(88)80449-4 · Cited by 18 · see citing works
Ipp, E., Sinai, Y., FORSTER, B., Cortez, C., Bar‐Oz, B., Nesher, R., & Cerasi, E. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-3-711 · Cited by 17 · see citing works
Self-citationLow, L. C. K., Yu, E. C. L., Chow, O. K. W., Yeung, C. Y., & YOUNG, R. T. T. (1989) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.1989.tb01446.x · Cited by 15 · see citing works
Pediatric surgery of the liver, pancreas, and spleen
Schiller, M. (1991) · Cited by 15 · see citing works
Surgical Treatment of Nesidioblastosis in Childhood
Dobroschke, J. C., Linder, R., & Otten, A. (1991) · Progress in pediatric surgery · doi:10.1007/978-3-642-88324-8_10 · Cited by 6 · see citing works
Hypoglycemic syndrome in infancy and childhood. A surgeon's perspective.
Moossa, A. R., Baker, L., & Lavelle-Jones, M. (1987) · PubMed Central · Cited by 5 · see citing works
The surgical treatment of hyperinsulinism in infancy and childhood
Simson, J. N. L., & Spitz, L. (1984) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(84)80152-9 · Cited by 5 · see citing works
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Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels
Aguilar‐Bryan, L., & Bryan, J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.2.0361 · Cited by 697 · see citing works
Pearson, E. R., Boj, S. F., Steele, A. M., Barrett, T. G., Stals, K. L., Hamilton-Shield, J. P., Ellard, S., Ferrer, J. P., & Hattersley, A. T. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040118 · Cited by 430 · see citing works
Practical management of hyperinsulinism in infancy
Aynsley-Green, A., Hussain, K., Hall, J., Saudubray, J., Nihoul‐Feketé, C., de Lonlay, P., Brunelle, F., Otonkoski, T., Thornton, P., & Lindley, K. J. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.82.2.f98 · Cited by 298 · see citing works
Hyperinsulinism in Infancy: From Basic Science to Clinical Disease
Dunne, M. J., Cosgrove, K. E., Shepherd, R. M., Aynsley-Green, A., & Lindley, K. J. (2004) · Physiological Reviews · doi:10.1152/physrev.00022.2003 · Cited by 294 · see citing works
Clinical features of 52 neonates with hyperinsulinism.
de Lonlay-Debeney, P., Poggi-Travert, F., Fournet, J., Sempoux, C., Vici, C., Brunelle, F., Touati, G., Rahier, J., Junien, C., Nihoul-Fékété, C., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904153401505 · Cited by 306 · see citing works
Flanagan, S. E., Clauin, S., Bellanné‐Chantelot, C., de Lonlay, P., Harries, L. W., Gloyn, A. L., & Ellard, S. (2008) · Human Mutation · doi:10.1002/humu.20838 · Cited by 241 · see citing works
Genetics of neonatal hyperinsulinism
Gläser, B., THORNTON, P. S., Otonkoski, T., & Junien, C. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.82.2.f79 · Cited by 220 · see citing works
Long-term follow-up of 114 patients with congenital hyperinsulinism
Meissner, T., Wendel, U., Burgard, P., Schaetzle, S., & Mayatepek, E. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490043 · Cited by 206 · see citing works
HYPERINSULINISM IN INFANTS AND CHILDREN
Stanley, C. A. (1997) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70481-8 · Cited by 209 · see citing works
Mechanisms of Disease: advances in diagnosis and treatment of hyperinsulinism in neonates
León, D. D. D., & Stanley, C. A. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0368 · Cited by 198 · see citing works
Huopio, H., Otonkoski, T., Vauhkonen, I., Reimann, F. M., Ashcroft, F. M., & Laakso, M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12325-2 · Cited by 184 · see citing works
Gloyn, A. L., Noordam, C., Willemsen, M. A. A. P., Ellard, S., Lam, W. W. K., Campbell, I. W., Midgley, P., Shiota, C., Buettger, C. W., Magnuson, M. A., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2433 · Cited by 168 · see citing works
Beltrand, J., Caquard, M., Arnoux, J., Laborde, K., Velho, G., Verkarre, V., Rahier, J., Brunelle, F., Nihoul‐Feketé, C., Saudubray, J., et al. (2011) · Diabetes Care · doi:10.2337/dc11-1296 · Cited by 155 · see citing works
Tornovsky-Babeay, S., Dadon, D., Ziv, O., Tzipilevich, E., Kadosh, T., Schyr, R. B., Hija, A., Stolovich-Rain, M., Furth‐Lavi, J., Granot, Z., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.007 · Cited by 149 · see citing works
Lord, K., Radcliffe, J., Gallagher, P. R., Adzick, N. S., Stanley, C. A., & León, D. D. D. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2539 · Cited by 138 · see citing works
Hyperinsulinism in Infancy and Childhood: When an Insulin Level Is Not Always Enough
Palladino, A., Bennett, M. J., & Stanley, C. A. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2007.098988 · Cited by 134 · see citing works
Grimberg, A., Ferry, R. J., Kelly, A. T., Koo-McCoy, S., Polonsky, K. S., Gläser, B., Permutt, M. A., Aguilar‐Bryan, L., Stafford, D. E. J., THORNTON, P. S., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.2.322 · Cited by 128 · see citing works
Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia of Infancy
Hussain, K. (2007) · Hormone Research in Paediatrics · doi:10.1159/000111789 · Cited by 112 · see citing works
Gloyn, A. L., Siddiqui, J., & Ellard, S. (2006) · Human Mutation · doi:10.1002/humu.20292 · Cited by 108 · see citing works
Rahier, Sempoux, C. L., Fournet, Poggi§, Brunelle, Nihoul‐Fekete, Saudubray, & Jaubert (1998) · Histopathology · doi:10.1046/j.1365-2559.1998.00326.x · Cited by 109 · see citing works
Arya, V. B., Senniappan, S., Demirbilek, H., Alam, S., Flanagan, S. E., Ellard, S., & Hussain, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098054 · Cited by 105 · see citing works
Shilyansky, J., Fisher, S. J., Cutz, E., Perlman, K., & Filler, R. M. (1997) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(97)90207-4 · Cited by 105 · see citing works
KATP channels and insulin secretion disorders
Huopio, H., Shyng, S., Otonkoski, T., & Nichols, C. G. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00047.2002 · Cited by 105 · see citing works
Hyperinsulinism and Beckwith-Wiedemann syndrome
Munns, C. F. (2001) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.84.1.f67 · Cited by 97 · see citing works
de Lonlay, P., Carré, A., Ribeiro, M. J., Boddaert, N., Giurgea, I., Laborde, K., Bellanné‐Chantelot, C., Verkarre, V., Polak, M., Rahier, J., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1713 · Cited by 89 · see citing works
Barthlen, W., Blankenstein, O., Mau, H., Koch, M., Höhne, C., Mohnike, W., Eberhard, T., Füchtner, F., Lorenz‐Depiereux, B., & Mohnike, K. L. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2036 · Cited by 82 · see citing works
Clinical practice guidelines for congenital hyperinsulinism
Yorifuji, T., Horikawa, R., Hasegawa, T., Adachi, M., Soneda, S., Minagawa, M., Ida, S., Yonekura, T., Kinoshita, Y., Kanamori, Y., et al. (2017) · Clinical Pediatric Endocrinology · doi:10.1297/cpe.26.127 · Cited by 74 · see citing works
Hyperinsulinism induced by targeted suppression of beta cell K ATP channels
Koster, J. C., Remedi, M. S., Flagg, T. P., Johnson, J. D., Markova, K., Marshall, B. A., & Nichols, C. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012479199 · Cited by 73 · see citing works
Treatment of Congenital Hyperinsulinism with Lanreotide Acetate (Somatuline Autogel)
Modan‐Moses, D., Koren, I., Mazor‐Aronovitch, K., Pinhas‐Hamiel, O., & Landau, H. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0605 · Cited by 68 · see citing works
Self-citationBaş, F., Darendeliler, F., Demirkol, D., Bundak, R., Saka, N., & Günöz, H. (1999) · Journal of Pediatric Endocrinology & Metabolism (JPEM) · doi:10.1515/jpem.1999.12.6.873 · Cited by 72 · see citing works
Long-term neurodevelopmental outcome in conservatively treated congenital hyperinsulinism
Mazor‐Aronovitch, K., Gillis, D., Lobel, D., Hirsch, H. J., Pinhas‐Hamiel, O., Modan‐Moses, D., Gläser, B., & Landau, H. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0445 · Cited by 62 · see citing works
Self-citationFamilial hyperinsulinism and pancreatic β-cell ATP-sensitive potassium channels
Sharma, N., Crane, A., González, G., Bryan, J., & Aguilar‐Bryan, L. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00918.x · Cited by 62 · see citing works
Pancreatic β-cell KATP channels: Hypoglycaemia and hyperglycaemia
Bennett, K., James, C. T., & Hussain, K. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9144-2 · Cited by 59 · see citing works
Abdulhadi‐Atwan, M., Bushman, J. D., Tornovsky-Babaey, S., Perry, A., Abu‐Libdeh, A., Gläser, B., Shyng, S., & Zangen, D. (2008) · Diabetes · doi:10.2337/db08-0159 · Cited by 58 · see citing works
Immuno-localization of sulphonylurea receptor 1 in rat pancreas
Suzuki, M., Fujikura, K., Kotake, K. T., Inagaki, N., Seino, S., & Takata, K. (1999) · Diabetologia · doi:10.1007/s001250051293 · Cited by 52 · see citing works
Hussain, K. (2005) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2005.03.001 · Cited by 51 · see citing works
Reinecke‐Lüthge, A., Koschoreck, F., & Klöppel, G. (2000) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/pl00008192 · Cited by 50 · see citing works
Laparoscopic vs open pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy
Al-Shanafey, S. N. (2009) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2009.01.042 · Cited by 48 · see citing works
Neonatal hypoglycaemia: aetiologies
de Lonlay, P., Giurgea, I., Touati, G., & Saudubray, J. (2003) · Seminars in Neonatology · doi:10.1016/j.siny.2003.08.002 · Cited by 48 · see citing works
Glucose metabolism and neurological outcome in congenital hyperinsulinism
Ludwig, A., Ziegenhorn, K., Empting, S., Meißner, T., Marquard, J., Holl, R. W., & Mohnike, K. L. (2010) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2010.10.005 · Cited by 45 · see citing works
Management of hyperinsulinism in infancy and childhood
Hussain, K., & Aynsley-Green, A. (2000) · Annals of Medicine · doi:10.3109/07853890008998834 · Cited by 45 · see citing works
Yorifuji, T., Kawakita, R., Nagai, S., Sugimine, A., Doi, H., Nomura, A., Masue, M., Nishibori, H., Yoshizawa, A., Okamoto, S., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1281 · Cited by 43 · see citing works
Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K+ Channels
Remedi, M. S., Koster, J. C., Markova, K., Seino, S., Miki, T., Patton, B. L., McDaniel, M. L., & Nichols, C. G. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3159 · Cited by 42 · see citing works
Somatostatin analogues for the treatment of hyperinsulinaemic hypoglycaemia
Haris, B., Saraswathi, S., & Hussain, K. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820965068 · Cited by 41 · see citing works
Diabetes and insulin secretion: whither KATP?
Nichols, C. G., & Koster, J. C. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00168.2002 · Cited by 41 · see citing works
Hyperinsulinism and Diabetes: Genetic Dissection of β Cell Metabolism-Excitation Coupling in Mice
Remedi, M. S., & Nichols, C. G. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.011 · Cited by 39 · see citing works
Reed, D. K., Korytko, A. I., Hipkin, R. W., Wehrenberg, W. B., Schönbrunn, A., & Cuttler, L. (1999) · Endocrinology · doi:10.1210/endo.140.10.7033 · Cited by 39 · see citing works
Jack, M., Greer, R. M., Thomsett, M. J., Walker, R. M., BELL, J. R., Choong, C. S., Cowley, D. M., Herington, A. C., & Cotterill, A. M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01725.x · Cited by 39 · see citing works
Hyperinsulinism of the newborn
Gläser, B. (2000) · Seminars in Perinatology · doi:10.1053/sp.2000.6365 · Cited by 38 · see citing works
Glucose metabolism: key endogenous regulator of β‐cell replication and survival
Dadon, D., Tornovsky-Babaey, S., Furth‐Lavi, J., Ben-Zvi, D. S., Ziv, O., Schyr, R. B., Stolovich-Rain, M., Hija, A., Porat, S., Granot, Z., et al. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01646.x · Cited by 37 · see citing works
Park, S. E., Flanagan, S. E., Hussain, K., Ellard, S., Shin, C. H., & Yang, S. W. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0160 · Cited by 37 · see citing works
The diabetic β‐cell: hyperstimulated vs. hyperexcited
Nichols, C. G., & Remedi, M. S. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01655.x · Cited by 36 · see citing works
Hyperinsulinemic hypoglycemia in infancy: Current concepts in diagnosis and management
Vora, S., Chandran, S., Rajadurai, V. S., & Hussain, K. (2015) · Indian Pediatrics · doi:10.1007/s13312-015-0772-1 · Cited by 34 · see citing works
Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism
Ismail, D., & Hussain, K. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9145-1 · Cited by 32 · see citing works
The spectrum of ABCC8 mutations in Norwegian patients with congenital hyperinsulinism of infancy
Sandal, T., Laborie, L., Brusgaard, K., Eide, S., Christesen, H. T., Søvik, O., Pr, N., & Molven, A. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2009.01152.x · Cited by 32 · see citing works
Persistent Hyperinsulinemic Hypoglycemia of Infancy: Long Term Results
Dacou‐Voutetakis, C., Psychou, F., & Maniati-Christidi, M. (1998) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1998.11.s1.131 · Cited by 32 · see citing works
Lu, M. H., & Li, C. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13448 · Cited by 28 · see citing works
Persistent hyperinsulinemic hypoglycemia of infancy: An overview of current concepts
Choudhury, S. R., & Goel, P. (2012) · Journal of Indian Association of Pediatric Surgeons · doi:10.4103/0971-9261.98119 · Cited by 29 · see citing works
Dominantly inherited hyperinsulinaemic hypoglycaemia
de Lonlay, P., Giurgea, I., Sempoux, C. L., Touati, G., Jaubert, F., Rahier, J., Ribeiro, M.-J., Brunelle, F., Nihoul‐Feketé, C., Robert, J., et al. (2005) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-005-7057-0 · Cited by 29 · see citing works
Cade, A., Walters, M. P., Puntis, J. W. L., Arthur, R. J., & Stringer, M. D. (1998) · Archives of Disease in Childhood · doi:10.1136/adc.79.5.435 · Cited by 29 · see citing works
Yu, W., Niwa, T., Miura, Y., Horio, F., Teradaira, S., Ribar, T. J., Means, A. R., Hasegawa, Y., Senda, T., & Niki, I. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000027921.01548.c5 · Cited by 28 · see citing works
Pancreatic regeneration after near-total pancreatectomy in children with nesidioblastosis
Berrocal, T., Álvarez-Luque, A., Pinilla, I., & Lassaletta, L. (2005) · Pediatric Radiology · doi:10.1007/s00247-005-1537-0 · Cited by 26 · see citing works
From congenital hyperinsulinism to diabetes mellitus: the role of pancreatic beta-cell KATP channels
Hussain, K., & Cosgrove, K. E. (2005) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2005.00109.x · Cited by 26 · see citing works
Laparoscopic pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy
Al-Shanafey, S. N., Habib, Z., & Al‐Nassar, S. (2009) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2008.10.120 · Cited by 25 · see citing works
Growth and endocrine function after near total pancreatectomy for hyperinsulinaemic hypoglycaemia.
Soliman, A. T., Salmi, I. A., Darwish, A., & Asfour, M. (1996) · Archives of Disease in Childhood · doi:10.1136/adc.74.5.379 · Cited by 25 · see citing works
Persistent hyperinsulinemic hypoglycemia of infancy
Cohen, M. M. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.20480 · Cited by 25 · see citing works
Gläser, B., Landau, H., & Permutt, M. A. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00102-7 · Cited by 25 · see citing works
Self-citationContemporary strategies in the diagnosis and management of neonatal hyperinsulinaemic hypoglycaemia
Lindley, K. J., & Dunne, M. J. (2004) · Early Human Development · doi:10.1016/j.earlhumdev.2004.10.007 · Cited by 24 · see citing works
HYPERINSULINEMIC HYPOGLYCEMIA OF INFANCY
Sperling, M. A., & Menon, R. K. (1999) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70097-9 · Cited by 24 · see citing works
Schwitzgebel, V., & Gitelman, S. E. (1998) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)31345-9 · Cited by 22 · see citing works
Milner, R. D. G. (1996) · Archives of Disease in Childhood · doi:10.1136/adc.74.5.369 · Cited by 22 · see citing works
Rapid Genetic Analysis in Congenital Hyperinsulinism
Christesen, H. T., Brusgaard, K., Alm, J., Sjöblad, S., Hussain, K., Fenger, C., Rasmussen, L. M., Hovendal, C. P., Otonkoski, T., & Jacobsen, B. B. (2006) · Hormone Research in Paediatrics · doi:10.1159/000097063 · Cited by 21 · see citing works
Genetics and Pathophysiology of Hyperinsulinism in Infancy
Cosgrove, K. E., Shepherd, R. M., Fernandez, E. M., Natarajan, A., Lindley, K. J., Aynsley-Green, A., & Dunne, M. J. (2004) · Hormone Research in Paediatrics · doi:10.1159/000076933 · Cited by 21 · see citing works
Welters, A., Meißner, T., Grulich‐Henn, J., Fröhlich-Reiterer, E. E., Warncke, K., Mohnike, K. L., Blankenstein, O., Menzel, U., Datz, N., Bollow, E., et al. (2018) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-018-0970-8 · Cited by 20 · see citing works
Dieterle, M. P., Husari, A., Prozmann, S. N., Wiethoff, H., Stenzinger, A., Röhrich, M., Pfeiffer, U., Kießling, W. R., Engel, H., Sourij, H., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11061732 · Cited by 19 · see citing works
Focal and diffuse beta cell changes in persistent hyperinsulinemic hypoglycemia of infancy
Klöppel, G., Reinecke‐Lüthge, A., & Koschoreck, F. (1999) · Endocrine Pathology · doi:10.1007/bf02739772 · Cited by 19 · see citing works
Genetic hypoglycaemia in infancy and childhood: Pathophysiology and diagnosis
Saudubray, J., de Lonlay, P., Touati, G., Martin, D., Nassogne, M., Castelnau, P., Sevin, C., Laborde, C., Baussan, C., Brivet, M., et al. (2000) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1005675827612 · Cited by 20 · see citing works
Managing congenital hyperinsulinism: improving outcomes with a multidisciplinary approach
Palladino, A., & Ackermann, A. M. (2015) · Research and Reports in Endocrine Disorders · doi:10.2147/rred.s56608 · Cited by 18 · see citing works
Lasting 18F-DOPA PET Uptake after Clinical Remission of the Focal Form of Congenital Hyperinsulinism
Yorifuji, T., Hosokawa, Y., Fujimaru, R., Kawakita, R., Doi, H., Matsumoto, T., Nishibori, H., & Masue, M. (2011) · Hormone Research in Paediatrics · doi:10.1159/000328056 · Cited by 18 · see citing works
Preclinical and Clinical Epigenetic-Based Reconsideration of Beckwith-Wiedemann Syndrome
Papulino, C., Chianese, U., Nicoletti, M. M., Benedetti, R., & Altucci, L. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.563718 · Cited by 18 · see citing works
Ten years’ experience of persistent hyperinsulinaemic hypoglycaemia of infancy
Tyrrell, V., Ambler, G. R., Yeow, W., Cowell, C., & Silink, M. (2001) · Journal of Paediatrics and Child Health · doi:10.1046/j.1440-1754.2001.00748.x · Cited by 18 · see citing works
Perge, K., & Nicolino, M. P. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09749-2 · Cited by 16 · see citing works
Dastamani, A., Güemes, M., Pitfield, C., Morgan, K., Rajab, M. H., Rottenburger, C., Bomanji, J. B., Coppi, P. D., Dattani, M., & Shah, P. (2018) · Hormone Research in Paediatrics · doi:10.1159/000491101 · Cited by 16 · see citing works
Zumkeller, W. (1999) · Endocrine Related Cancer · doi:10.1677/erc.0.0060421 · Cited by 16 · see citing works
Rother, K. I., Matsumoto, J. M. S., Rasmussen, N. H., & Schwenk, W. F. (2001) · Pediatric Diabetes · doi:10.1034/j.1399-5448.2001.002003115.x · Cited by 16 · see citing works
Someya, T., Miki, T., Sugihara, S., Minagawa, M., YASUDA, T., Kohno, Y., & Seino, S. (2000) · Endocrine Journal · doi:10.1507/endocrj.47.715 · Cited by 14 · see citing works
Mahachoklertwattana, P., Suprasongsin, C., Teeraratkul, S., & PREEYASOMBAT, C. (2000) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2000.13.1.37 · Cited by 14 · see citing works
Imaging and intervention in the gastrointestinal tract in children
Kaye, R. D., & Towbin, R. B. (2002) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(02)00024-9 · Cited by 13 · see citing works
Permanent neonatal diabetes mellitus: Epidemiology, mode of presentation, pathogenesis and growth
Soliman, A. T., Elzalabany, M. S., Bappal, B., Salmi, I. A., de Silva, V., & Asfour, M. G. (1999) · The Indian Journal of Pediatrics · doi:10.1007/bf02845526 · Cited by 13 · see citing works
A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life
Vedovato, N., Salguero, M. V., Greeley, S. A. W., Yu, C. H., Philipson, L. H., & Ashcroft, F. M. (2024) · Diabetologia · doi:10.1007/s00125-024-06103-w · Cited by 12 · see citing works
L'hyperinsulinisme congénital du nouveau-né et du nourrisson
Giurgea, I., Ribeiro, M. L., Boddaert, N., Touati, G., Robert, J.-J., Saudubray, J., Jaubert, F., Bellanné‐Chantelot, C., Brunelle, F., Nihoul‐Feketé, C., et al. (2005) · Archives de Pédiatrie · doi:10.1016/j.arcped.2005.07.016 · Cited by 12 · see citing works
Persistent hyperinsulinemic hypoglycemia of infancy
Thomas, P. M., & Cote, G. J. (1997) · Cancer treatment and research · doi:10.1007/978-1-4615-6355-6_16 · Cited by 12 · see citing works
[18F]Fluoro-L-DOPA PET/CT in Congenital Hyperinsulinism
Subramaniam, R. M., Karantanis, D., & Peller, P. J. (2007) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0b013e318031f55c · Cited by 11 · see citing works
Coexistence in the Same Family of Both Focal and Diffuse Forms of Hyperinsulinism
Valayannopoulos, V., Vaxillaire, M., Aigrain, Y. Y., Jaubert, F., Bellanné‐Chantelot, C., Ribeiro, M. J., Brunelle, F., Froguel, P., Robert, J., Polak, M., et al. (2007) · Diabetes Care · doi:10.2337/dc06-2327 · Cited by 11 · see citing works
Persistent hyperinsulinemic hypoglycemia of infancy.
Desai, M. P., & Khatri, J. V. (1998) · PubMed · Cited by 11 · see citing works
Zhang, J., Li, L., & Cheng, W. (2016) · Pediatric Surgery International · doi:10.1007/s00383-016-3943-9 · Cited by 11 · see citing works
Clemente, M., Cobo, P., Antolı́n, M., Campos-Martorell, A., Yeste, D., Tomasini, R., Caimari, M., Masas, M., García‐Arumí, E., Fernández‐Cancio, M., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad280 · Cited by 10 · see citing works
Hiperinsulinismo congénito. Revisión de 22 casos
Guerrero-Fernández, J., Casado, I. G., Colindres, L. E., & Bouthelier, R. G. (2006) · Anales de Pediatría · doi:10.1157/13090894 · Cited by 10 · see citing works
Cure of hypoglycemic hyperinsulinism by enucleation of a focal islet cell adenomatous hyperplasia
Craver, R. D., & Hill, C. B. (1997) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(97)90584-4 · Cited by 10 · see citing works
Leibowitz, G., Weintrob, N., Pikarsky, A. J., JOSEFSBERG, Z., Landau, H., Gläser, B., Hales, C. N., & Cerasi, E. (1996) · Diabetologia · doi:10.1007/s001250050580 · Cited by 10 · see citing works
Self-citation
- Authors
- Leibowitz, G., Glaser, B., Higazi, A. A., Salameh, M., Cerasi, E., & Landau, H.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1995-02
- Volume
- 80
- Issue
- 2
- Pages
- 386-392
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1967142752
- Cited by
- 156
- References
- 32
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 2 · 2012: 6
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion, cc-by)
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hadassah Medical Organization
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- nesidioblastosis, diabetes mellitus, beta-cell dysfunction, subtotal pancreatectomy, glucose tolerance, glucose disposal, insulin secretion, long-term follow-up, puberty, medical treatment
- MeSH terms
- Adolescent, C-Peptide, Child, Diabetes Mellitus, Diazoxide, Female, Follow-Up Studies, Glucose Tolerance Test, Humans, Islets of Langerhans, Male, Pancreatectomy, Pancreatic Diseases, Prospective Studies, Time Factors, Octreotide
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