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Cited by 321Menopause: Health Impacts and TreatmentsHormonal and reproductive studiesEstrogen and related hormone effects

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Body Weight, Body Fat Distribution, and Hormonal Replacement Therapy in Early Postmenopausal Women

Gambacciani, M., Ciaponi, M., Cappagli, B., Piaggesi, L., De Simone, L., Orlandi, R., Genazzani, A. R.·1997·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.82.2.3735
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Abstract

Body weight was measured, and body fat distribution was determined by dual energy x-ray in early postmenopausal women given either oral calcium (500 mg/day; control group; n = 12) or hormonal replacement therapy (HRT), a combination of estradiol valerate (2 mg/day for 21 days) with cyproterone acetate (1 mg/day in the last 10 days of the treatment cycle; n = 15). There were no differences in basal body weight or body fat distribution in the two groups before the study. In the control group, a significant (P < 0.05) increase in body weight (from 63.6 +/- 2.2 to 65.2 +/- 1.9 kg [corrected] after 12 months) paralleled a slight, but significant (P < 0.05), increase in total body fat mass (from 23.8 +/- 2.2 to 24.7 +/- 2.2 kg), with an increase in fat in the trunk (from 10.2 +/- 0.4 to 11.3 +/- 0.4 kg; P < 0.01) and arms (from 2.4 +/- 0.5 to 2.7 +/- 0.2 kg; P < 0.05). These findings demonstrate a shift to a prevalent central android fat distribution after 12 months of observation in untreated postmenopausal women. Conversely, in the HRT group, total body bone mineral showed a significant (from 1089 +/- 28 to 1106 +/- 29 mg/cm2; P < 0.05) increase after 12 months, with no significant increase in body weight (from 62.2 +/- 1.6 to 62.7 +/- 1.6 kg), and no modifications in trunk (from 10.0 +/- 0.2 to 9.8 +/- 0.3 kg) and arm (from 2.43 +/- 0.2 to 2.5 +/- 0.1 kg) fat, but a significant increase in leg fat (from 7.1 +/- 0.3 to 8.3 +/- 0.4 kg; P < 0.05). The present results suggest that HRT can counteract at least in part the postmenopausal increase in body weight and body fat and prevent central body fat distribution after menopause.

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Crossref · 10.1210/jcem.82.2.3735

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Metadata

Authors
Gambacciani, M., Ciaponi, M., Cappagli, B., Piaggesi, L., De Simone, L., Orlandi, R., & Genazzani, A. R.
Affiliations
University of Pisa (IT)
Corresponding author
Gambacciani, M.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1997-02
Volume
82
Issue
2
Pages
414-417
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.82.2.3735
OpenAlex
W2063248917
Cited by
321
References
27
Citations by year
2026: 2 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 13 · 2017: 8 · 2016: 9 · 2015: 12 · 2014: 8 · 2013: 16 · 2012: 11
FWCI
7.84
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords
postmenopausal women, body weight, body fat distribution, abdominal obesity, android fat, estradiol valerate, cyproterone acetate, bone mineral density, calcium supplementation, leg fat, trunk fat, arm fat, menopause, osteoporosis prevention, dual-energy X-ray absorptiometry, body composition changes
MeSH terms
Adipose Tissue, Body Composition, Body Weight, Calcium, Female, Humans, Middle Aged, Reference Values, Estrogen Replacement Therapy, Postmenopause

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