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Cited by 173Menopause: Health Impacts and TreatmentsHormonal and reproductive studiesEstrogen and related hormone effects

Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy

Gambacciani, M., Ciaponi, M., Cappagli, B., De Simone, L., Orlandi, R., Genazzani, A.R.·2001·Maturitas
DOI 10.1016/s0378-5122(01)00194-3
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Abstract

Aims In order to assess the effects of menopause and hormonal replacement therapy (HRT) on body weight and body fat distribution (determined by dual energy X-ray), early postmenopausal women were given either oral calcium (500 mg/day, control group, n=13) or HRT, a combination of estradiol valerate (EV, 2 mg/day for 21 days) with cyproterone acetate (CPA, 1 mg/day in the last 10 days of the treatment cycle, n=18; Climen, Schering).Results There were no differences in basal body weight and body fat distribution in the two groups before the study. In control group, a significant (P<0.05) increase in body weight (from 63.5+/-2.0 to 68.7+/-2.0 kg after 36 months) paralleled a shift to a prevalent central, android fat distribution with a slight but significant (P<0.05) increase in total body fat mass (from 23.4+/-2.1 to 29.1+/-2.1 kg), an increase in trunk (from 10.1+/-0.4 to 12.7+/-0.4 kg, P<0.05), arms (from 2.4+/-0.2 to 2.9+/-0.2 kg, P<0.05) and legs (from 6.5+/-0.4 to 7.8+/-0.4 kg, P<0.05) fat. In the HRT group total body bone mineral showed a significant increase (from 1086+/-21 to 1128+/-19 mg/cm(2), P<0.05) increase after 36 months, with no significant increase in body weight (from 62.6+/-1.8 to 65.0+/-1.9 kg), and no modifications in trunk (from 10.0+/-0.2 to 10.1+/-0.2 kg) and arms (from 2.4+/-0.1 to 2.6+/-0.1 kg) fat, but a significant increase in legs fat (from 6.9+/-0.3 to 9.9+/-0.4 kg, P<0.05).Conclusion Present results demonstrate that menopause is associated with an accelerated increase in body weight and body fat, with a prevalent central, android fat distribution, that can be counteracted at least in part by oral HRT.

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  • Metabolic derangements linked to the risk of cardiovascular disease, including weight gain, decreased insulin sensitivity, dyslipidaemia, and hypertension, are prevalent in women with risk factors for cardiovascular disease specific to women.

    “Metabolic derangements linked to the risk of cardiovascular disease, including weight gain, decreased insulin sensitivity, dyslipidaemia, and hypertension, are prevalent in women with risk factors for cardiovascular disease specific to women”

    From Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review (2020) · cites this paper as [140]

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Authors
Gambacciani, M., Ciaponi, M., Cappagli, B., De Simone, L., Orlandi, R., & Genazzani, A. R.
Affiliations
University of Pisa (IT)
Corresponding author
Gambacciani, M.
ORCID
Gambacciani, M.
Venue
Maturitas
Publisher
Elsevier BV
Published
2001-08
Volume
39
Issue
2
Pages
125-132
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/s0378-5122(01)00194-3
OpenAlex
W2145306208
Cited by
173
References
31
Citations by year
2026: 3 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 10 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 10 · 2013: 6 · 2012: 14
FWCI
3.91
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
hormone replacement therapy, postmenopausal women, body weight, body fat distribution, abdominal obesity, android fat, estradiol valerate, cyproterone acetate, bone mineral density, calcium supplementation, menopause, body composition, trunk fat, leg fat, arm fat, dual-energy X-ray absorptiometry
MeSH terms
Adipose Tissue, Body Composition, Body Weight, Calcium, Dietary, Estradiol, Female, Humans, Menopause, Middle Aged, Prospective Studies, Absorptiometry, Photon, Case-Control Studies, Cyproterone Acetate, Hormone Replacement Therapy

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