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Cited by 277

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Sex-Related Difference in the Growth of Prolactinomas: A Clinical and Proliferation Marker Study1

Open access
Delgrange, Etienne, Trouillas, Jacqueline, Maiter, Dominique, Donckier, Julian, Tourniaire, Jacques·1997·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.82.7.4088
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Abstract

Prolactinomas in women commonly present as small intrasellar tumors, but are usually much larger in men. This discrepancy has generally been attributed to differences in the delay before diagnosis. However, studies comparing clinical and pathological correlates of growth of these tumors in both sexes are lacking. We conducted a retrospective study comparing 45 men and 51 women bearing prolactinoma to determine whether the predominance of large tumors in men was due to a delay in diagnosis or, rather, to a fundamental sex-related difference in tumor growth. Basal PRL levels (mean +/- SEM, 2789 +/- 573 ng/mL) and mean tumor diameter (26 +/- 2 mm) were significantly higher in men than in women (292 +/- 74 ng/mL and 10 +/- 1 mm, respectively; P < 0.001), but were not correlated to the age at diagnosis or the duration of symptoms. Giant tumors (n = 8) occurred in males only. The frequencies of bromocriptine-resistant tumors (30 vs.5%; P < 0.01) and invasive macroadenomas (52 vs.27%; P < 0.001) were significantly greater in men than those in women. Lastly, macroprolactinomas in males exhibited higher indexes of proliferating cells by Ki-67 immunoreactivity (2.6 +/- 1.1% of positive nuclei) than did similar tumors in female patients (0.4 +/- 0.2%; P = 0.08). We conclude that the predominance of large prolactinomas in men is due to a high frequency of rapidly growing tumors, which are often invasive and frequently bromocriptine resistant.

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Metadata

Authors
Delgrange, E., Trouillas, J., Maiter, D., Donckier, J., & Tourniaire, J.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1997-07
Volume
82
Issue
7
Pages
2102-2107
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.82.7.4088
OpenAlex
W2090071140
Cited by
277
References
17
FWCI
3.32
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Sex-Related Difference in the Growth of Prolactinomas: A Clinical and Proliferation Marker Study1. https://app.cochat.ai/papers/10.1210/jcem.82.7.4088
The paper
Delgrange, E., Trouillas, J., Maiter, D., Donckier, J., & Tourniaire, J. (1997). Sex-Related Difference in the Growth of Prolactinomas: A Clinical and Proliferation Marker Study1. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.82.7.4088

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.