The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
High fluid intake increases urine free cortisol excretion in normal subjects.
Abstract
To test the hypothesis that increased fluid intake increases the urine free cortisol, we prescribed 5 liters of fluid intake per day or a normal fluid intake according to a randomized cross-over design in six normal volunteers. Each period lasted 5 days, with a 2-day washout period of normal fluid intake between the two periods. Urine free cortisol, 17-hydroxycorticosteroids, and creatinine were measured daily during each study period, and the average value over each 5-day period was calculated for each subject. High fluid intake caused a significant increase in the mean urine free cortisol [126 +/- 33 (SD) vs. 77 +/- 18 micrograms/day, P < 0.005]. The frequency of urine free cortisol results that exceeded the upper normal limit of 95 micrograms/day was also much higher during high fluid intake (23/30 vs. 6/30, P < 0.005). By contrast, urine 17-hydroxycorticosteroids (high fluid vs. normal fluid: 5.3 +/- 1.5 vs. 5.0 +/- 1.7 mg/day, respectively, P = not significant) and urine creatinine (1.51 +/- 0.48 vs. 1.45 +/- 0.37 g/day, P = not significant) did not differ between the two study periods. We conclude that high fluid intake (5 liters/day) increases free cortisol excretion without an increase in urine 17-hydroxycorticosteroids. Thus, mild to moderate increases in urine cortisol excretion may not indicate hypercortisolism in individuals who have a high fluid intake and urine volume.
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“High fluid intake (Ն5 liters/d) significantly increases UFC (52).”
From The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. (2008) · cites this paper as [52]
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Cites
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A QUANTITATIVE COLOR REACTION FOR CORTISONE AND RELATED 17,21-DIHYDROXY-20-KETOSTEROIDS
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Self-citationDelivery and Transport of Glucocorticoids to Target Cells
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DOUBTFUL 24-H URINARY CORTISOL/CORTISONE RATIO TO MONITOR TRAINING EFFECTS IN ELITE SWIMMERS
Atlaoui, D., Lacour, J. R., Duclos, M., & Chatard, J. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000155706.48783.07
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Vlera e kortizolit të lirë urinar në diagnostikimin e sindromës Cushing: Eksperienca jonë
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Biochemical diagnosis of hypercortisolism: When and how?
Asla, Q., Urgell, E., Terzan, S., Marín, R., Vives, A. S., Webb, S. M., & Aulinas, A. (2026) · Vitamins and hormones · doi:10.1016/bs.vh.2026.03.001
Metadata
- Authors
- Mericq, M. V., & Cutler, G. B.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Cutler, Gordon B.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1998-02
- Volume
- 83
- Issue
- 2
- Pages
- 682-684
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2171909930
- Cited by
- 111
- References
- 16
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
- Keywords
- fluid intake, urinary free cortisol, cortisol excretion, 17-hydroxycorticosteroids, urinary creatinine, hypercortisolism, urine output, normal subjects
- MeSH terms
- Adult, Creatinine, Drinking, Female, Humans, Hydrocortisone, Male, Urine, 17-Hydroxycorticosteroids
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