Cited by 111Adrenal Hormones and DisordersStress Responses and CortisolElectrolyte and hormonal disorders

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

High fluid intake increases urine free cortisol excretion in normal subjects.

Mericq, M. Veronica, Cutler, Gordon B.·1998·The Journal of Clinical Endocrinology & Metabolism

Open this paper in CoChat — free account

Abstract

To test the hypothesis that increased fluid intake increases the urine free cortisol, we prescribed 5 liters of fluid intake per day or a normal fluid intake according to a randomized cross-over design in six normal volunteers. Each period lasted 5 days, with a 2-day washout period of normal fluid intake between the two periods. Urine free cortisol, 17-hydroxycorticosteroids, and creatinine were measured daily during each study period, and the average value over each 5-day period was calculated for each subject. High fluid intake caused a significant increase in the mean urine free cortisol [126 +/- 33 (SD) vs. 77 +/- 18 micrograms/day, P < 0.005]. The frequency of urine free cortisol results that exceeded the upper normal limit of 95 micrograms/day was also much higher during high fluid intake (23/30 vs. 6/30, P < 0.005). By contrast, urine 17-hydroxycorticosteroids (high fluid vs. normal fluid: 5.3 +/- 1.5 vs. 5.0 +/- 1.7 mg/day, respectively, P = not significant) and urine creatinine (1.51 +/- 0.48 vs. 1.45 +/- 0.37 g/day, P = not significant) did not differ between the two study periods. We conclude that high fluid intake (5 liters/day) increases free cortisol excretion without an increase in urine 17-hydroxycorticosteroids. Thus, mild to moderate increases in urine cortisol excretion may not indicate hypercortisolism in individuals who have a high fluid intake and urine volume.

Integrity signals

Registry

Crossref · 10.1210/jcem.83.2.4555

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma
DUNN, J. F., NISULA, B. C., & RODBARD, D. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-58 · Cited by 1,238
LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR
Edwards, C. R. W., Burt, D., McIntyre, M., de Kloet, E. R., Stewart, P. M., Brett, L., Sutanto, W. S., & Monder, C. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90742-8 · Cited by 1,067
A QUANTITATIVE COLOR REACTION FOR CORTISONE AND RELATED 17,21-DIHYDROXY-20-KETOSTEROIDS
Porter, C. C., & SILBER, R. H. (1950) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56408-5 · Cited by 564
A Radioimmunoassay for Cortisol in Plasma and Urine
Ruder, H. J., Guy, R. L., & Lipsett, M. B. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-2-219 · Cited by 330
Urine Free Cortisol in the High-Dose Dexamethasone Suppression Test for the Differential Diagnosis of the Cushing Syndrome
Flack, M. R., Oldfield, E. H., Cutler, G. B., ZWEIG, M. H., Malley, J. D., Chrousos, G. P., Loriaux, D. L., & Nieman, L. K. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-3-211 · Cited by 161
Self-citation
Delivery and Transport of Glucocorticoids to Target Cells
Ballard, P. L. (1979) · Monographs on endocrinology · doi:10.1007/978-3-642-81265-1_2 · Cited by 145
Urinary Free Cortisol and Cortisone Determined by High Performance Liquid Chromatography in the Diagnosis of Cushing’s Syndrome1
Lin, C., Wu, T.-J., Machacek, D., Jiang, N., & Kao, P. C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.1.3687 · Cited by 138
AN ABNORMALITY IN STEROID REDUCTIVE METABOLISM IN A HYPERTENSIVE SYNDROME
Ulick, S., Ramirez, L. C., & New, M. I. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-44-4-799 · Cited by 112
Physiology of Urinary Cortisol Excretion
Beisel, W. R., COS, J. J., Horton, R., Chao, P. Y., & Forsham, P. H. (1964) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-24-9-887 · Cited by 108
Lack of Specificity of Cortisol Determinations in Human Urine
Murphy, B. E. P., OKOUNEFF, L. M., Klein, G. P., NGO, S. C., Kropp, K. Α., & Mulrow, P. J. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-91 · Cited by 85

Flagged first, then by citations

Show all 16 references

Sorted by citations

The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.
Nieman, L. K., Biller, B. M. K., Findling, J. W., Newell-Price, J., Savage, M. O., Stewart, P. M., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0125 · Cited by 2,718
Consensus on diagnosis and management of Cushing's disease: a guideline update
Fleseriu, M., Auchus, R., Bancos, I., Ben-Shlomo, A., Bertherat, J., Biermasz, N. R., Boguszewski, C. L., Bronstein, M. D., Buchfelder, M., Carmichael, J. D., et al. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00235-7 · Cited by 953
Reduced Cortisol Metabolism during Critical Illness
Boonen, E., Vervenne, H., Meersseman, P., Andrew, R., Mortier, L., Declercq, P. E., Vanwijngaerden, Y.-M., Spriet, I., Wouters, P. J., Vander Perre, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214969 · Cited by 477
Cushing's syndrome: update on signs, symptoms and biochemical screening
Nieman, L. K. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0464 · Cited by 385
Approach to the Patient with Possible Cushing’s Syndrome
Boscaro, M., & Arnaldi, G. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0612 · Cited by 251
A physiologic approach to diagnosis of the Cushing syndrome.
Raff, H., & Findling, J. W. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-12-200306170-00010 · Cited by 186
Diagnosis and differential diagnosis of Cushing’s syndrome
Findling, J. W., & Raff, H. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70209-7 · Cited by 147
Cushing's syndrome: Overview of clinical presentation, diagnostic tools and complications
Barbot, M., Zilio, M., & Scaroni, C. M. (2020) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2020.101380 · Cited by 126
Cognitive dietary restraint is associated with higher urinary cortisol excretion in healthy premenopausal women
McLean, J. A., Barr, S. I., & Prior, J. C. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.1.7 · Cited by 106
Newer diagnostic techniques and problems in Cushing’s disease
Findling, J. W., & Raff, H. (1999) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70063-3 · Cited by 97
The diagnosis of Cushing’s syndrome
Carroll, T. B., & Findling, J. W. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9143-3 · Cited by 95
Cushing Syndrome: Maybe Not So Uncommon of an Endocrine Disease
Guaraldi, F., & Salvatori, R. (2012) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2012.02.110227 · Cited by 86
Recent Updates on the Diagnosis and Management of Cushing's Syndrome
Nieman, L. K. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.2.139 · Cited by 85
Toward a Diagnostic Score in Cushing's Syndrome
Braun, L., Riester, A., Osswald-Kopp, A., Fazel, J., Rubinstein, G., Bidlingmaier, M., Beuschlein, F., & Reincke, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00766 · Cited by 90
Pitfalls in the diagnosis and management of Cushing's syndrome
Bansal, V., Asmar, N. E., Selman, W. R., & Arafah, B. M. (2015) · Neurosurgical FOCUS · doi:10.3171/2014.11.focus14704 · Cited by 81
Accuracy of late-night salivary cortisol in evaluating postoperative remission and recurrence in Cushing’s disease
Amlashi, F. G., Swearingen, B., Faje, A. T., Nachtigall, L. B., Miller, K. K., Klibanski, A., Biller, B. M. K., & Tritos, N. A. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2107 · Cited by 66
Cushing’s Disease
Nishioka, H., & Yamada, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111951 · Cited by 65
Increased cortisol level
Cagnacci, A., Cannoletta, M., Caretto, S., Zanin, R., Xholli, A., & Volpe, A. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181f31947 · Cited by 65
Prolonged Suppression of Corticosteroid-Binding Globulin by Recombinant Human Interleukin-6 in Man
Tsigos, C., Kyrou, I., Chrousos, G. P., & Papanicolaou, D. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5100-5 · Cited by 50
Cushing's syndrome: a practical approach to diagnosis and differential diagnoses
Pappachan, J. M., Hariman, C., Edavalath, M., Waldron, J., & Hanna, F. (2017) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2016-203933 · Cited by 46
The dexamethasone‐suppressed corticotrophin‐releasing hormone stimulation test in anorexia nervosa
Duclos, M., Corcuff, J., Roger, P., & Tabarin, A. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00872.x · Cited by 45
High Cognitive Dietary Restraint Is Associated With Increased Cortisol Excretion in Postmenopausal Women
Rideout, C. A., Linden, W., & Barr, S. I. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.628 · Cited by 42
Urinary Free Cortisol Determinations: What They Measure
Murphy, B. E. P. (2002) · The Endocrinologist · doi:10.1097/00019616-200203000-00013 · Cited by 42
How Much “UFC” Is Really Cortisol?
Murphy, B. E. P. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.6.793 · Cited by 41
Urinary free cortisol and cortisone excretion in healthy individuals: Influence of water loading
Fenske, M. J. (2006) · Steroids · doi:10.1016/j.steroids.2006.08.004 · Cited by 40
24 h urinary free cortisol in large-scale epidemiological studies: Short-term and long-term stability and sources of variability
Rosmalen, J. G. M., Kema, I. P., Wüst, S., van der Ley, C., Visser, S. T., Snieder, H., & Bakker, S. J. L. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.018 · Cited by 37
Brief review: Glucocorticoid excretion in obesity
Müssig, K., Remer, T., & Maser-Gluth, C. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.01.008 · Cited by 36
Lack of Specificity of Urinary Free Cortisol Determinations: Why Does It Continue?
Murphy, B. E. P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5809-3 · Cited by 35
Salt Loading Affects Cortisol Metabolism in Normotensive Subjects: Relationships with Salt Sensitivity
Kerstens, M. N., van der Kleij, F. G. H., Boonstra, A. H., Sluiter, W. J., Koerts, J., Navis, G. J., & Dullaart, R. P. F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021625 · Cited by 33
Do patients with type 2 diabetes mellitus have an increased prevalence of Cushing’s syndrome?
Krarup, T., Krarup, T., & Hagen, C. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2262 · Cited by 30
Late-night salivary cortisol may be valuable for assessing treatment response in patients with Cushing’s disease: 12-month, Phase III pasireotide study
Findling, J. W., Fleseriu, M., Newell-Price, J. D. C., Petersenn, S., Pivonello, R., Kandra, A., Pedroncelli, A. M., & Biller, B. M. K. (2016) · Endocrine · doi:10.1007/s12020-016-0978-6 · Cited by 30
Steroid profiling in the diagnosis of mild and overt Cushing’s syndrome
Athimulam, S., Grebe, S. K. G., & Bancos, I. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101488 · Cited by 30
Current Challenges and Future Directions in the Assessment of Glucocorticoid Status
Clarke, S. A., Eng, P. C., Comninos, A. N., Lazarus, K., Choudhury, S., Tsang, C., Meeran, K. M., Tan, T., Dhillo, W. S., & Abbara, A. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae016 · Cited by 33
Differential Mobility Spectrometry-Mass Spectrometry (DMS-MS) in Radiation Biodosimetry: Rapid and High-Throughput Quantitation of Multiple Radiation Biomarkers in Nonhuman Primate Urine
Chen, Z., Coy, S. L., Pannkuk, E. L., Laiakis, E. C., Fornace, A. J., & Vouros, P. (2018) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-018-1977-z · Cited by 29
Diagnostic approach to Cushing disease
Gross, B. A., Mindea, S. A., Pick, A. J., Chandler, J. P., & Batjer, H. H. (2007) · Neurosurgical FOCUS · doi:10.3171/foc-07/09/e1 · Cited by 28
Tailored reference limits for urine corticoid:creatinine ratio in dogs to answer distinct clinical questions
Zeugswetter, F. K., Bydzovsky, N. D., Kampner, D., & Schwendenwein, I. (2010) · Veterinary Record · doi:10.1136/vr.c4010 · Cited by 28
Dysfunction of the hypothalamic-pituitary-adrenal axis and functional somatic symptoms: A longitudinal cohort study in the general population
Tak, L. M., Bakker, S. J. L., & Rosmalen, J. G. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.12.017 · Cited by 26
Daily urinary free cortisol and cortisone excretion is associated with urine volume in healthy children
Shi, L., Maser‐Gluth, C., & Remer, T. (2008) · Steroids · doi:10.1016/j.steroids.2008.08.002 · Cited by 22
The management of glucocorticoid deficiency: Current and future perspectives
Dineen, R., Martin‐Grace, J., Thompson, C. J., & Sherlock, M. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.03.006 · Cited by 21
Subclinical Cushing Syndrome
Starker, L. F., Kunstman, J. W., & Carling, T. (2014) · Surgical Clinics of North America · doi:10.1016/j.suc.2014.02.008 · Cited by 21
Reliability of 24-h void frequency as an index of hydration status when euhydrated and hypohydrated
Tucker, M. A., Gonzalez, M. A., Adams, J. D., Burchfield, J. M., Moyen, N. E., Robinson, F. B., Schreiber, B. A., & Ganio, M. S. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.233 · Cited by 18
The management of Cushing's disease - from investigation to treatment.
Juszczak, A., & Grossman, A. B. (2013) · PubMed · Cited by 17
Neutrophil‐Lymphocyte Ratio as an Initial Screening Biomarker for Differential Diagnosis of Cushing’s Syndrome from Nonfunctional Adenoma in Patients with an Adrenal Mass
Wang, W., Wang, J., Shen, C., Zhu, S., Gao, Y., & Zhang, J. (2021) · BioMed Research International · doi:10.1155/2021/6635594 · Cited by 17
How Much “Urinary Free Cortisol” Is Really Cortisol during Water Diuresis in Healthy Individuals?
Fenske, M. J. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.032243 · Cited by 17
Pitfalls in the Diagnosis and Management of Hypercortisolism (Cushing Syndrome) in Humans; A Review of the Laboratory Medicine Perspective
Flowers, K. C., & Shipman, K. E. (2023) · Diagnostics · doi:10.3390/diagnostics13081415 · Cited by 17
Neurosurgical treatment of Cushing disease
Sheth, S. A., Bourne, S. K., Tritos, N. A., & Swearingen, B. (2012) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2012.06.006 · Cited by 15
Effects of childhood adversity and cortisol levels on suicidal ideation and behaviour: Results from a general population study
Gartland, N., Rosmalen, J. G. M., & O'Connor, D. B. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105664 · Cited by 15
When to Intervene for Subclinical Cushing's Syndrome
Hsieh, L. B., MacKinney, E. C., & Wang, T. S. (2019) · Surgical Clinics of North America · doi:10.1016/j.suc.2019.04.011 · Cited by 14
Urinary Free Cortisol Is Unrelated to Physiological Changes in Urine Volume in Healthy Women
Putignano, P., Dubini, A., & Cavagnini, F. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.6.879 · Cited by 14
Avtomatizirovannyy elektrokhemilyuminestsentnyy metod opredeleniya kortizola v slyune dlya diagnostiki endogennogo giperkortitsizma sredi patsientov s ozhireniem
Belaya, Z. E., Ильин, А. В., Melnichenko, G. A., Rozhinskaya, L. Y., Dragunova, N. V., Dzeranova, L. K., Ogneva, N. A., Бутрова, С. А., Troshina, E. A., Kolesnikova, G. S., et al. (2011) · Obesity and metabolism · doi:10.14341/2071-8713-4954 · Cited by 15
Thin-Layer Chromatographic Competitive Protein-Binding Assay for Cortisol and Cortisone, and its Application to Urine Samples from Healthy Men Undergoing Water Diuresis
Fenske, M. J. (2006) · Chromatographia · doi:10.1365/s10337-006-0751-8 · Cited by 13
Reliability of the diagnostic tests for Cushing’s syndrome performed in a tertiary referral center
Güneş, M., Celik, O., & Kadıoğlu, P. (2012) · Pituitary · doi:10.1007/s11102-012-0387-7 · Cited by 12
Urinary Free Cortisol Is Not Affected by Short-term Water Diuresis
Fenske, M. J. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.2.316 · Cited by 11
Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children
Shi, L., Wudy, S. A., Maser‐Gluth, C., Hartmann, M. F., & Remer, T. (2010) · Steroids · doi:10.1016/j.steroids.2010.10.004 · Cited by 10
Current views of the screening and diagnostics of endogenous hypercorticism
Белая, Ж. Е., Рожинская, Л. Я., Mel'nichenko, G. A., & Dedov, I. I. (2012) · Problems of Endocrinology · doi:10.14341/probl201258435-41 · Cited by 10
Pułapki w diagnostyce incydentaloma nadnerczy
Cyrańska-Chyrek, E., Grzymisławska, M., & Ruchała, M. (2017) · Endokrynologia Polska · doi:10.5603/ep.2017.0028 · Cited by 10
Comment on High Urinary Free Cortisol Excretion in a Patient with Psychogenic Polydipsia
Friedman, T. C., & Papanicolaou, D. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5100-3 · Cited by 10
Effect of Thyroxine on Low Density Lipoprotein Oxidation Another Thyroid Hormone Nongenomic Effect
Benvenga, S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5100-1 · Cited by 9
Adrenal disorders
Kline, G. A., & Chin, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803412-5.00005-7 · Cited by 8
Urinary free cortisone, but not cortisol, is associated with urine volume in severe obesity
Müssig, K., Remer, T., Fritsche, A., Häring, H., & Maser‐Gluth, C. (2009) · Steroids · doi:10.1016/j.steroids.2009.03.007 · Cited by 8
Association Between Urinary Catecholamine Excretion and Urine Volume
Haap, M. M., Blaschka, F. A., Lehmann, R., Hoyer, A., & Müssig, K. (2019) · Hormone and Metabolic Research · doi:10.1055/a-0926-3532 · Cited by 7
The Role of the Clinical Laboratory in the Diagnosis of Cushing Syndrome
Garcia, C. A., Biller, B. M. K., & Klibanski, A. (2003) · Pathology Patterns Reviews · doi:10.1309/5bhrvaq1vjbg43w4 · Cited by 6
No Change in 24-Hour Hydration Status Following a Moderate Increase in Fluid Consumption
Tucker, M. A., Adams, J. D., Brown, L. A., Ridings, C. B., Burchfield, J. M., Robinson, F. B., McDermott, J. L., Schreiber, B. A., Moyen, N. E., Washington, T. A., et al. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1046196 · Cited by 6
Decreased cortisol production in male type 1 diabetic patients
Kerstens, M. N., Luik, P. T., van der Kleij, F. G. H., Boonstra, A. H., Breukelman, H., Sluiter, W. J., Navis, G. J., & Dullaart, R. P. F. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01171.x · Cited by 6
Measuring Hormones: Considerations for Biospecimen Collection, Assay, and Analysis
Moody, S. N., Stephens, A. I., Phan, J., Miočević, O., Kapoor, A., Wang, W., Steenis, A. L. V., Le, S. T., van Dammen, L., & Shirtcliff, E. A. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009000796.020 · Cited by 5
Desenvolvimento e caracterização de método para a dosagem de cortisol livre urinário
Vieira, J. G. H., Noguti, K. O., Rayol, M. D. P., & Maciel, R. M. B. (2000) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302000000300008 · Cited by 5
Carbamazepine and falsely positive screening tests for Cushing's syndrome.
Tiong, K., & Falhammar, H. (2009) · PubMed · Cited by 5
Advances in the Diagnosis and Medical Management of Cushing's Syndrome
Delivanis, D. A., Sharma, A. R., Hamidi, O., Shah, M., & Bancos, I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-66195-9.00015-7 · Cited by 5
Cushing Disease: Diagnosis and Treatment
Tatsi, C., & Stratakis, C. A. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-11339-1_5 · Cited by 5
The Investigation of Cushing Syndrome: Essentials in Optimizing Appropriate Diagnosis and Management
Juszczak, A., & Grossman, A. B. (2012) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2012.455 · Cited by 4
Urinary Free Cortisol Is Similar in Older and Younger Women
Carvalhaes-Neto, N., Ramos, L. R., Vieira, J. G. H., & Kater, C. E. (2002) · Experimental Aging Research · doi:10.1080/03610730252800175 · Cited by 4
Actualización en el diagnóstico y diagnóstico diferencial del síndrome de Cushing
Moreira-Andrés, M. N., Gómez, F. J. D. C., & Carranza, F. H. (2003) · Revista Clínica Española · doi:10.1016/s0014-2565(03)71222-3 · Cited by 4
Low Impact of Urinary Cortisol in the Assessment of Hydrocortisone Replacement Therapy
Haas, C. S., Rahvar, A., Danneberg, S., Lehnert, H., Moenig, H., & Harbeck, B. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-108729 · Cited by 4
Poor correlation between 6β‐hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity: a comment
Fenske, M. J. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02804.x · Cited by 4
Making the Diagnosis: Laboratory Testing and Imaging Studies
Nieman, L. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804340-0.00005-x · Cited by 3
Cortisol: mediciones de laboratorio y aplicación clínica
Hernandez-Quiceno, S., Uribe-Bojanini, E., Velásquez, J. M. A., Campuzano‐Maya, G., & Salazar-Peláez, L. M. (2016) · Medicina y Laboratorio · doi:10.36384/01232576.74 · Cited by 3
Cushing Syndrome: Presentation, Diagnosis, and Treatment, Including Subclinical Cushing Syndrome
Neychev, V. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-44136-8_9 · Cited by 3
Measuring cortisol in Cushing syndrome: diagnosis, monitoring, and cortisol circadian rhythm improvement.
Hamidi, O., St-Jean, M., Lacroix, A., & Bancos, I. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag095 · Cited by 5
Hypothalamic–pituitary–adrenal axis activity in patients with primary polydipsia compared to healthy controls
Sailer, C. O., Kühne, J., da Conceição, I., Refardt, J. C., Christ‐Crain, M., & Winzeler, B. F. (2022) · Clinical Endocrinology · doi:10.1111/cen.14835 · Cited by 2
Impaired 11β-HSD1 Activity in a Male Patient With Cushing Disease Resulting in Lack of the Full Cushingoid Phenotype
Weber, R. J., Kawaja, C., Wallerstein, R. J., Kunwar, S. M., & Liu, C. (2024) · JCEM Case Reports · doi:10.1210/jcemcr/luae158 · Cited by 2
Le défi du diagnostic du syndrome de Cushing
Faure, P., Monneret, D., Martinie, M., & Chabre, O. (2008) · Immuno-analyse & Biologie Spécialisée · doi:10.1016/j.immbio.2007.12.001 · Cited by 2
Urine cortisol and cortisone and water intake in athletes.
Gatti, R. D., Antonelli, G., Zecchin, B., Spinella, P., Mantero, F., & Palo, E. F. D. (2008) · PubMed · Cited by 2
MENSURAÇÃO DOS NÍVEIS SÉRICOS DE CORTISOL E DE LACTATO DESIDROGENASE COMO INDICADORES DE ESTRESSE EM CUTIA (Dasyprocta azarae)
Acco, A. (1998) · Archives of Veterinary Science · doi:10.5380/avs.v3i1.3769 · Cited by 2
Diagnostics of Cushing's disease in the children (a literature review)
Udalova, N. (2011) · Problems of Endocrinology · doi:10.14341/probl201157557-62 · Cited by 1
Dosage du cortisol urinaire : considérations analytiques et pré-analytiques
Doggui, R. (2013) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(13)71828-8 · Cited by 1
Relevance and perspective concept of investigation of subclinical Cushing syndrome.
Kuznetsov, N. S., Latkina, N. V., & Kaminarskaya, Y. A. (2016) · Endocrine Surgery · doi:10.14341/serg2016113-22 · Cited by 1
Cushing’s Disease in Children and Adolescents: Diagnosis and Management
Richmond, E. J., & Rogol, A. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804340-0.00011-5 · Cited by 1
Physiopathology, Diagnosis, and Treatment of Hypercortisolism
Pivonello, R., Iacuaniello, D., Simeoli, C., Martino, M. C. D., & Colao, A. (2018) · Endocrinology · doi:10.1007/978-3-319-44444-4_12 · Cited by 1
DOUBTFUL 24-H URINARY CORTISOL/CORTISONE RATIO TO MONITOR TRAINING EFFECTS IN ELITE SWIMMERS
Fenske, M. J. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000155705.65497.d9 · Cited by 1
The Association Between Levels of Cortisol Secretion and Fear Perception in Patients With Remitted Depression Predicts Recurrence
Fenske, M. J. (2007) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000258303.22562.49 · Cited by 1
The functional state of pituitary-adrenal system in the adolescents and younger males with hy-pertension
Кубачева, К. К., Великанова, Л. И., Ворохобина, Н. В., & Sil'nitskiĭ, P. A. (2009) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2009-15-3-320-324 · Cited by 1
Corticoïdes et pratique sportive intense
Duclos, M. (2008) · Bio Tribune Magazine · doi:10.1007/s11834-008-0051-8
Authors' response: Poor correlation between 6β‐hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity: a comment
Chen, Y., Nafziger, A. N., Bertino, J., & Kashuba, A. D. M. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02805.x
Urinary Free Cortisol Excretion in Humans: A Comment on the Article by Huang and Co-Workers
Fenske, M. J. (2007) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e318156ea19
Physiologic roles of 11β-hydroxysteroid dehydrogenase type 2 in kidney: a comment on the article of Isomura et al
Fenske, M. J. (2007) · Metabolism · doi:10.1016/j.metabol.2007.08.002
Proper assessment of free corticosteroid excretion in human urine depends not only on the use of a reproducible analytical method but also on the attention that urine volume may be an important pre‐analytical parameter: a comment on the work of Al Sharef and co‐workers
Fenske, M. J. (2007) · Biomedical Chromatography · doi:10.1002/bmc.929
Trauma - logistics and stress response
Brorsson, C. (2014) · DiVA at Umeå University (Umeå University)
Abnormalities of the hypothalamus–pituitary–adrenal axis in patients with Anorexia Nervosa are not really reflected by free corticosteroid excretion
Fenske, M. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.08.003
For information on reprint requests of more than 101 and commercial reprints contact
Barbour, L. A., Cobin, R. H., DeGroot, L. J., Glinoer, D., Mandel, S. J., & Edwards, H. A. (2008)
TRABAJOS ESPECIALES MANEJO DE PACIENTES CON SÍNDROME DE CUSHING.
Lima-Martínez, M. M., Zerpa, J., Guerrero, Y., Rivera, J., & Vielma, M. (2013)

Authors: Mericq, M. V., & Cutler, G. B.
Affiliations: National Institutes of Health (US)
ORCID: Cutler, Gordon B.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1998-02
Volume: 83
Issue: 2
Pages: 682-684
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.83.2.4555
OpenAlex: W2171909930
Cited by: 111
References: 16
Citations by year: 2026: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 5
FWCI: 3.22
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords: fluid intake, urinary free cortisol, cortisol excretion, 17-hydroxycorticosteroids, urinary creatinine, hypercortisolism, urine output, normal subjects
MeSH terms: Adult, Creatinine, Drinking, Female, Humans, Hydrocortisone, Male, Urine, 17-Hydroxycorticosteroids

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

High fluid intake increases urine free cortisol excretion in normal subjects.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks