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Cited by 102Vasculitis and related conditionsThyroid Disorders and TreatmentsSystemic Lupus Erythematosus Research

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

High Prevalence of Antineutrophil Cytoplasmic Antibody Positivity in Childhood Onset Graves’ Disease Treated with Propylthiouracil

Sato, Hirokazu, Hattori, Motoshi, Fujieda, Mikiya, Sugihara, Shigetaka, Inomata, Hiroaki, Hoshi, Mari, Miyamoto, Shigeki·2000·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.85.11.7000
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Abstract

Propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-related vasculitis and nephritis were recently reported in about 30 patients with hyperthyroidism. The objective of this study was to clarify the prevalence of ANCA and the relationship between ANCA and thyroid antibodies in children with Graves’ disease. Titers of myeloperoxidase (MPO)-ANCA in sera of 51 patients with childhood onset Graves’ disease (16 before treatment, 25 and 10 treated with PTU and methimazole, respectively) were measured by enzyme-linked immunosolvent assay. Antithyroglobulin antibodies (TGAbs) and antithyroperoxidase antibodies (TPOAbs) were also measured by RIA in 25 PTU-treated patients. No patients had clinical manifestations of vasculitis and nephritis. MPO-ANCA was positive in 6.7% of patients before treatment and in 64.0% of those treated with PTU and in none of those treated with methimazole. MPO-ANCA had a significantly positive correlation with TGAbs (P < 0.05) and no significant correlation with TPOAbs. These findings show the high prevalence of the MPO-ANCA positivity in PTU-treated childhood onset Graves’ disease, suggesting that PTU may not be preferred as the first line for the treatment of children with Graves’ disease. The significant correlation between MPO-ANCA and TGAbs indicates that the severity of Graves’ disease may be a factor responsible for the MPO-ANCA positivity. The cross-reactivity between MPO-ANCA and TPOAbs may not play a role in the high prevalence of MPO-ANCA in the patients exposed to PTU.

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Research works printed but not linked: 6

  1. 1994, PTU-induced vasculitis., Jpn J Nephrol, 36, 1354
  2. 1995, PTU-induced vasculitis., Jpn J Nephrol, 37, 701
  3. 1995, PTU-induced vasculitis., Jpn J Nephrol, 37, 701
  4. Nagasawa, 1995, Fundamental and clinical MPO-ANCA ELISA kit (Nissho)., Rinkenkikai, Shiyaku, 18, 127
  5. Nagasawa, 1992, C-ANCA investigated by ELISA kit (BioCarb) and its clinical usefulness in Wegener’s granulomatosis., Rinkenkikai, Shiyaku, 15, 503
  6. Hirooka, 1992, Fundamental and clinical evaluation of the measurement of autoantibodies to thyroglobulin and to thyroid peroxidase by highly sensitive radioimmunoassay methods., Clin Endocrinol (Tokyo), 40, 547

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Metadata

Authors
Sato, H., Hattori, M., Fujieda, M., Sugihara, S., Inomata, H., Hoshi, M., & Miyamoto, S.
Affiliations
  • Chiba Children's Hospital (JP)
  • Kochi Medical School Hospital (JP)
  • Tokyo Women's Medical University (JP)
  • Teikyo University (JP)
  • Matsudo City Hospital (JP)
  • Divisions of Endocrinology (H.S., S.M.), Chiba 266-0007
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2000-11-01
Volume
85
Issue
11
Pages
4270-4273
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.85.11.7000
OpenAlex
W1996277373
Cited by
102
References
32
Citations by year
2024: 1 · 2021: 3 · 2020: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
5.66
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords
propylthiouracil, antineutrophil cytoplasmic antibodies, MPO-ANCA, antithyroid drug adverse effects, thyroglobulin antibodies, hyperthyroidism, methimazole, disease severity
MeSH terms
Adolescent, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Graves Disease, Humans, Iodide Peroxidase, Japan, Male, Methimazole, Peroxidase, Propylthiouracil, Thyroglobulin, Antithyroid Agents, Age of Onset, Immunoglobulins, Thyroid-Stimulating, Antibodies, Antineutrophil Cytoplasmic

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