The spectrum of thyroid diseases in childhood and its evolution during transition to adulthood: Natural history, diagnosis, differential diagnosis and management

Koch, C. A.; Sarlis, Nicholas J.

doi:10.1007/bf03343911

Cited by 36Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid Surgery

The spectrum of thyroid diseases in childhood and its evolution during transition to adulthood: Natural history, diagnosis, differential diagnosis and management

Koch, C. A., Sarlis, Nicholas J.·2001·Journal of Endocrinological Investigation

DOI 10.1007/bf03343911

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Abstract

In this contribution, we review current knowledge on the pathogenesis, diagnosis and differential diagnosis of thyroid disorders in childhood and adolescence, as well as present an update on therapy methods and management guidelines for these disorders. This overview is conceptually divided into two parts, one focusing on thyroid functional disorders, i.e. conditions leading to hyper- and hypothyroidism, and another one pertinent to structural abnormalities of the thyroid gland, i.e. nodular disorders and thyroid cancer. Currently, congenital hypothyroidism is diagnosed in a much more timely fashion rather than in the past, rendering hypothyroidism-related mental retardation and developmental deficits very rare in newborns and children and, hence, diminishing significantly its public health impact. At the same time, considerable advances have occurred in our understanding of the molecular basis of several genetic conditions affecting the thyroid gland in childhood, such as familial non-autoimmune hyperthyroidism, as well as of the pathways leading to thyroid neoplasia.

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Progressively lower L-T4 doses are required in the transition to adulthood.
“Progressively lower doses are required in the transition to adulthood [54].”
From 2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism (2018) · cites this paper as [54]

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Authors: Koch, C. A., & Sarlis, N. J.
Affiliations: National Institutes of Health (US)
Corresponding author: Sarlis, Nicholas J.
ORCID: Koch, C. A.
Venue: Journal of Endocrinological Investigation
Publisher: Springer Science and Business Media LLC
Published: 2001-10
Volume: 24
Issue: 9
Pages: 659-675
ISSN: 0391-4097 (ISSN-L)
1720-8386
DOI: 10.1007/bf03343911
OpenAlex: W2091799083
Cited by: 36
References: 124
Citations by year: 2023: 2 · 2021: 2 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 1
FWCI: 0.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Endocrinological Investigation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords: adolescence, coming of age, congenital hypothyroidism, hyperthyroidism, hypothyroidism, thyroid nodules, thyroid cancer, differential diagnosis, thyroid hormone replacement, natural history (disease)
MeSH terms: Adolescent, Adult, Child, Congenital Hypothyroidism, Diagnosis, Differential, Humans, Hyperthyroidism, Hypothyroidism, Infant, Newborn, Thyroid Diseases, Thyroid Neoplasms, Thyroid Nodule

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The spectrum of thyroid diseases in childhood and its evolution during transition to adulthood: Natural history, diagnosis, differential diagnosis and management

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