CoChat
Sign Up
Cited by 190Sexual Differentiation and DisordersAdrenal Hormones and DisordersHormonal Regulation and Hypertension

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Flutamide, Testolactone, and Reduced Hydrocortisone Dose Maintain Normal Growth Velocity and Bone Maturation Despite Elevated Androgen Levels in Children with Congenital Adrenal Hyperplasia

Merke, Deborah P., Keil, Margaret F., Jones, Janet V., Fields, Jeremy, Hill, Suvimol, Cutler, Gordon B.·2000·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.85.3.6462
Open this paper in CoChat — free account

Abstract

Treatment outcome in congenital adrenal hyperplasia is often sub-optimal due to hyperandrogenism, treatment-induced hypercortisolism, or both. We previously reported better control of linear growth, weight gain, and bone maturation in a short term cross-over study of a new four-drug treatment regimen containing an antiandrogen (flutamide), an inhibitor of androgen to estrogen conversion (testolactone), reduced hydrocortisone dose, and fludrocortisone, compared to the effects of a control regimen of hydrocortisone and fludrocortisone. Twenty-eight children have completed 2 yr of follow-up in a subsequent long term randomized parallel study comparing these two treatment regimens. During 2 yr of therapy, compared to children receiving hydrocortisone, and fludrocortisone treatment, children receiving flutamide, testolactone, reduced hydrocortisone dose (average of 8.7 +/- 0.6 mg/m2 x day), and fludrocortisone had significantly (P < or = 0.05) higher plasma 17-hydroxyprogesterone, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and testosterone levels. Despite elevated androgen levels, children receiving the new treatment regimen had normal linear growth rate (at 2 yr, 0.1 +/- 0.5 SD units), and bone maturation (at 2 yr, 0.7 +/- 0.3 yr bone age/yr chronological age). No significant adverse effects were observed after 2 yr. We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess. A long term study of this new regimen is ongoing.

Overview

Integrity signals

Registry

Crossref · 10.1210/jcem.85.3.6462

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 190

Related

See all

Metadata

Authors
Merke, D. P., Keil, M. F., Jones, J. V., Fields, J., Hill, S., & Cutler, G. B.
Affiliations
  • Warren Grant Magnuson Clinical Center (D.P.M., S.H.), Bethesda, Maryland 20892
  • Developmental Endocrinology Branch (D.P.M., M.F.K., J.V.J., J.F., G.B.C.), Bethesda, Maryland 20892
  • National Institutes of Health (US)
Corresponding author
Merke, Deborah P.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2000-03-01
Volume
85
Issue
3
Pages
1114-1120
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.85.3.6462
OpenAlex
W1997037606
Cited by
190
References
28
Citations by year
2026: 6 · 2025: 5 · 2024: 9 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 2
FWCI
3.59
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
congenital adrenal hyperplasia, flutamide, testolactone, fludrocortisone, hyperandrogenism, linear growth velocity, skeletal maturation, glucocorticoid excess, 17-hydroxyprogesterone, androgen to estrogen conversion, pediatric endocrinology
MeSH terms
Adrenal Hyperplasia, Congenital, Androgen Antagonists, Androgens, Anti-Inflammatory Agents, Bone Development, Child, Child, Preschool, Female, Flutamide, Follow-Up Studies, Growth, Hormones, Humans, Hydrocortisone, Male, Testolactone, Weight Gain, Antineoplastic Agents, Hormonal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review