The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Effect of Short-Term Glucose Control on Glycemic Thresholds for Epinephrine and Hypoglycemic Symptoms
Abstract
Hypoglycemia is the principal barrier to achieving target glucose goals in type 2 diabetes. The effect of short-term improvement in glycemic control on plasma glucose thresholds for symptomatic and hormonal responses to hypoglycemia in type 2 diabetes is not known. We hypothesized that the thresholds for these events would be increased by 1 wk of improved glycemic control in elderly patients with type 2 diabetes. Ten elderly patients with type 2 diabetes were admitted for an 8-d inpatient protocol. All subjects underwent insulin-induced hypoglycemia on days 2 (preglucose control) and 8 (postglucose control). Between days 2 and 8, subjects received intensive diabetes management to improve their glycemic control. Timed blood glucose profiles were obtained daily during the week before and during admission. Plasma glucose, counterregulatory hormones, and hypoglycemic symptoms were assessed at baseline and every 10 min during the hypoglycemic studies. Mean blood glucose concentrations were significantly reduced by intensive diabetes management from 9.8 +/- 3.7 mmol/liter to 7.7 +/- 3.3 mmol/liter (P < 0.001). The plasma glucose threshold for epinephrine release during insulin-induced hypoglycemia was significantly increased by intensive management from a glucose concentration of 3.7 +/- 0.5 mmol/liter at baseline to 3.1 +/- 0.3 mmol/liter after intensive management (P < 0.05). The plasma glucose threshold for hypoglycemic symptoms was also increased by intensive therapy from a glucose concentration of 5.3 +/- 1.2 to 3.3 +/- 0.6 mmol/liter (P = 0.003). These rapid changes may increase the risk for severe hypoglycemia in type 2 diabetes and limit the ability of physicians to rapidly correct hyperglycemia in elderly type 2 diabetes patients.
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“The intensi fi cation of glycemic control in the elderly patient is associated with an increased reduction in the plasma glucose thresholds for epinephrine release and for the appearance of hypoglycemia (56).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [56]
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Altered Hierarchy of Protective Responses Against Severe Hypoglycemia in Normal Aging in Healthy Men
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Seaquist, E. R., Anderson, J., Childs, B., Cryer, P., Dagogo-Jack, S., Fish, L., Heller, S. R., Rodriguez, H., Rosenzweig, J., & Vigersky, R. (2013) · Diabetes Care · doi:10.2337/dc12-2480 · Cited by 1,389
“The intensification of glycemic control in the elderly patient is associated with an increased reduction in the plasma glucose thresholds for epinephrine release and for the appearance of hypoglycemia (56).”
BackgroundSeaquist, E. R., Anderson, J., Childs, B., Cryer, P., Dagogo-Jack, S., Fish, L., Heller, S. R., Rodriguez, H., Rosenzweig, J., & Vigersky, R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4127 · Cited by 412
Neuroendocrine responses to hypoglycemia
Tesfaye, N., & Seaquist, E. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05820.x · Cited by 164
Hypoglycaemia in Elderly Patients with Diabetes Mellitus
Chelliah, A., & Burge, M. R. (2004) · Drugs & Aging · doi:10.2165/00002512-200421080-00003 · Cited by 166
Self-citationCan volatile compounds in exhaled breath be used to monitor control in diabetes mellitus?
Smith, D. C., Španěl, P., Fryer, A. A., Hanna, F., & Ferns, G. A. (2011) · Journal of Breath Research · doi:10.1088/1752-7155/5/2/022001 · Cited by 100
Metadata
- Authors
- Burge, M. R., Sobhy, T. A., Qualls, C. R., & Schade, D. S.
- Affiliations
- University of New Mexico (US)
- Corresponding author
- Burge, Mark R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2001-11
- Volume
- 86
- Issue
- 11
- Pages
- 5471-5478
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2046503730
- Cited by
- 17
- References
- 38
- Citations by year
- 2026: 1 · 2014: 1 · 2013: 2
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsches Krebsforschungszentrum
- National Institutes of Health (5k23dk002680-03)
- National Institute of Diabetes and Digestive and Kidney Diseases (1-K23-DK02680-01)
- National Center for Research Resources (5M01-RR00997, M01RR000997)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, hypoglycemia, glycemic control, intensive diabetes management, insulin-induced hypoglycemia, epinephrine secretion, hypoglycemic symptoms, counterregulatory hormones, elderly patients
- MeSH terms
- Aged, Blood Glucose, Diabetes Mellitus, Type 2, Epinephrine, Female, Glyburide, Glycated Hemoglobin, Humans, Hydrocortisone, Hypoglycemia, Hypoglycemic Agents, Insulin, Male, Middle Aged, Body Mass Index
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