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Cited by 56Diabetes Management and ResearchBarrier Structure and Function StudiesPancreatic function and diabetes

Vascular Endothelial Growth Factor: A Novel Endocrine Defensive Response to Hypoglycemia

Dantz, Dorle, Bewersdorf, Jan, Fruehwald-Schultes, Bernd, Kern, Werner, Jelkmann, Wolfgang, Born, Jan, Fehm, Horst L., Peters, Achim·2002·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.87.2.8215
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Abstract

Glucose, the most important fuel for the brain, is supplied by the actions of counterregulatory hormones and the sympathetic nervous system. Yet to obtain access to the brain, glucose must pass the blood-brain barrier. Here we show that vascular endothelial growth factor (VEGF), a potent regulator of blood vessel function, is a candidate hormone for facilitating glucose passage across the blood-brain barrier under critical conditions. In 16 healthy men, VEGF serum concentrations increased under 6 h of insulin-induced hypoglycemic conditions from 86.1 +/- 13.4 to 211.6 +/- 40.8 pg/ml (P = 0.002), whereas in the hyperinsulinemic euglycemic control condition, no change was observed. During hypoglycemia serum VEGF, but no other counterregulatory hormone, was associated with preserved neurocognitive function, as measured with a memory test (r = 0.539; P = 0.031) and the Stroop interference task (r = 0.569; P = 0.021). Findings show that acute hypoglycemia is accompanied by a brisk increase in circulating VEGF concentration and that VEGF could mediate rapid adaptation of the brain to neuroglycopenia.

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  • The large variability in glycaemic thresholds in type 1 diabetes can probably be explained by different prior hypoglycaemia exposure rates between individuals, the loss of glucagon secretion within years after diagnosis, blunted catecholamine responses and impaired hypoglycaemic awareness.

    “This large variability in glycaemic thresholds in type 1 diabetes can probably be explained by different prior hypoglycaemia exposure rates between individuals [7], the loss of glucagon secretion within years after diagnosis [9, 10], blunted catecholamine responses and impaired hypoglycaemic awareness [11, 12].”

    From Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review (2022) · cites this paper as [9]

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Authors
Dantz, D., Bewersdorf, J., Fruehwald-Schultes, B., Kern, W., Jelkmann, W., Born, J., Fehm, H. L., & Peters, A.
Affiliations
University of Lübeck (DE)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2002-02
Volume
87
Issue
2
Pages
835-840
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.87.2.8215
OpenAlex
W2037402580
Cited by
56
References
42
Citations by year
2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
vascular endothelial growth factor, hypoglycemia, counterregulatory hormones, blood-brain barrier, glucose transport, neuroglycopenia, neurocognitive function, insulin-induced hypoglycemia, hyperinsulinemic-euglycemic clamp, memory, executive function
MeSH terms
Adult, Blood Glucose, Brain, Cognition, Humans, Hyperinsulinism, Hypoglycemia, Insulin, Lymphokines, Male, Memory, Neuropsychological Tests, Osmolar Concentration, Glucose Clamp Technique, Endothelial Growth Factors, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A

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