The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns
Open accessAbstract
The effects of thyroid hormone (TH) on development and metabolism are exerted at the cellular level. Metabolism and action of TH take place intracellularly, which require transport of the hormone across the plasma membrane. This process is mediated by TH transporter proteins. Many TH transporters have been identified at the molecular level, although a few are classified as specific TH transporters, including monocarboxylate transporter (MCT)8, MCT10, and organic anion-transporting polypeptide 1C1. The importance of TH transporters for physiology has been illustrated dramatically by the causative role of MCT8 mutations in males with psychomotor retardation and abnormal serum TH concentrations. Although Mct8 knockout animals have provided insight in the mechanisms underlying parts of the endocrine phenotype, they lack obvious neurological abnormalities. Thus, the pathogenesis of the neurological abnormalities in males with MCT8 mutations is not fully understood. The prospects of identifying other transporters and transporter-based syndromes promise an exciting future in the TH transporter field.
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“In the past two decades it has become clear that TH needs to be taken up in cells by specific transporters including monocarboxylate transporter 8 (MCT8), monocarboxylate transporter 10 (MCT10) and organic anion transporting polypeptide family 1C1 (OATP1C1) to exert its action at the cellular level [1].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [1]
In the citing paper
“These carriers appear to be necessary components of the feedback control, as simulated for IBS and demonstrated for MCT8 deficiency (27, 65).”
From Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment (2015) · cites this paper as [65]
In the citing paper
“Contrary to earlier assumptions, T3 and T4 do not diffuse freely across the plasma membrane but are actively transported by specialized transport proteins, such as MCT8, MCT10, and OATP1C1 (65).”
From Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment (2015) · cites this paper as [65]
In the citing paper
“T3 supply is locally controlled by several mechanisms, such as active thyroid hormone uptake, tissue-specific expression and activity of two distinct types of deiodinases converting T3 from T4, and thyroid hormone inactivation by deiodination or degradation by sulfatation, deamination, or glucoronidation (57–66).”
From Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment (2015) · cites this paper as [65]
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Citations
Cites
PEST sequences and regulation by proteolysis
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Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
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Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
Friesema, E. C. H., Ganguly, S., Abdalla, A., Fox, J. E. M., Halestrap, A. P., & Visser, T. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300909200 · Cited by 725
Self-citationFriesema, E. C., Grueters, A., Biebermann, H., Krude, H., von Moers, A., Reeser, M., Barrett, T. G., Mancilla, E. E., Svensson, J., Kester, M. H., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17226-7 · Cited by 709
Self-citationDumitrescu, A. M., Liao, X.-H., Best, T. B., Brockmann, K., & Refetoff, S. (2004) · The American Journal of Human Genetics · doi:10.1086/380999 · Cited by 706
Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1
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Molecular Basis of Thyroid Hormone-Dependent Brain Development
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Global Protein Stability Profiling in Mammalian Cells
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Research works printed but not linked: 7
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- Trajkovic, 2007, The thyroid hormone transporter MCT8 is critically involved in the uptake of T3 into the mouse CNS., Thyroid, 17, 1171
- Deure, 2008, OATP1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism., Endocrinology, 149, 1495
- Kinne, 2009, Surface translocation and T3 uptake of mutant MCT8 proteins are cell type-dependent., J Mol Endocrinol, 43, 263, 10.1677/JME-09-0043 · DOI
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- Dumitrescu, 2007, High circulating T3 in Mct8 deficient mice is an age related postnatal event dependent on the ontogeny of deiodinases, Endocrinology (Abstract)
- Hameed, 2009, 3,5-Diiodothyropropionic acid (DITPA) in the treatment of patients with MCT8 deficiency: a preliminary study, Lawson Wilkins Pediatric Endocrine Society/European Society for Pediatric Endocrinology, New York, NY
Cited by
Sorted by citations
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
Thyroid Hormone Regulation of Metabolism
Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“This diversity results from cells and tissues varying in terms of their expression of transmembrane transporters, deiodinases, nuclear TR subtypes, and coregulators (9,358,359).”
Mechanisms of thyroid hormone action
Brent, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60047 · Cited by 1,244
The SLC16 gene family – Structure, role and regulation in health and disease
Halestrap, A. P. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.05.003 · Cited by 768
Metadata
- Authors
- Visser, W. E., Friesema, E. C. H., & Visser, T. J.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Visser, Theo J.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2011-01-01
- Volume
- 25
- Issue
- 1
- Pages
- 1-14
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC5417302
- OpenAlex
- W1991454487
- Cited by
- 390
- References
- 101
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 11 · 2023: 13 · 2022: 17 · 2021: 20 · 2020: 23 · 2019: 34 · 2018: 22 · 2017: 40 · 2016: 37 · 2015: 34 · 2014: 40 · 2013: 32 · 2012: 23
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Endocrinology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Keywords
- thyroid hormone transporters, thyroid hormones, MCT8, MCT10, OATP1C1, monocarboxylate transporters, organic anion transporting polypeptides, psychomotor retardation, neurological abnormalities
- MeSH terms
- Animals, Humans, Mutation, Thyroid Hormones, Monocarboxylic Acid Transporters
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