The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns
Open accessAbstract
The effects of thyroid hormone (TH) on development and metabolism are exerted at the cellular level. Metabolism and action of TH take place intracellularly, which require transport of the hormone across the plasma membrane. This process is mediated by TH transporter proteins. Many TH transporters have been identified at the molecular level, although a few are classified as specific TH transporters, including monocarboxylate transporter (MCT)8, MCT10, and organic anion-transporting polypeptide 1C1. The importance of TH transporters for physiology has been illustrated dramatically by the causative role of MCT8 mutations in males with psychomotor retardation and abnormal serum TH concentrations. Although Mct8 knockout animals have provided insight in the mechanisms underlying parts of the endocrine phenotype, they lack obvious neurological abnormalities. Thus, the pathogenesis of the neurological abnormalities in males with MCT8 mutations is not fully understood. The prospects of identifying other transporters and transporter-based syndromes promise an exciting future in the TH transporter field.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In the past two decades it has become clear that TH needs to be taken up in cells by specific transporters including monocarboxylate transporter 8 (MCT8), monocarboxylate transporter 10 (MCT10) and organic anion transporting polypeptide family 1C1 (OATP1C1) to exert its action at the cellular level [1].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [1]
In the citing paper
“These carriers appear to be necessary components of the feedback control, as simulated for IBS and demonstrated for MCT8 deficiency (27, 65).”
From Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment (2015) · cites this paper as [65]
In the citing paper
“Contrary to earlier assumptions, T3 and T4 do not diffuse freely across the plasma membrane but are actively transported by specialized transport proteins, such as MCT8, MCT10, and OATP1C1 (65).”
From Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment (2015) · cites this paper as [65]
In the citing paper
“T3 supply is locally controlled by several mechanisms, such as active thyroid hormone uptake, tissue-specific expression and activity of two distinct types of deiodinases converting T3 from T4, and thyroid hormone inactivation by deiodination or degradation by sulfatation, deamination, or glucoronidation (57–66).”
From Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment (2015) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PEST sequences and regulation by proteolysis
Rechsteiner, M., & Rogers, S. W. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10031-1 · Cited by 1,707
Halestrap, A. P., & Meredith, D. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1067-2 · Cited by 1,047
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., Zeöld, A., & Bianco, A. C. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0019 · Cited by 891
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
Friesema, E. C. H., Ganguly, S., Abdalla, A., Fox, J. E. M., Halestrap, A. P., & Visser, T. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300909200 · Cited by 725
Self-citationFriesema, E. C., Grueters, A., Biebermann, H., Krude, H., von Moers, A., Reeser, M., Barrett, T. G., Mancilla, E. E., Svensson, J., Kester, M. H., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17226-7 · Cited by 709
Self-citationDumitrescu, A. M., Liao, X.-H., Best, T. B., Brockmann, K., & Refetoff, S. (2004) · The American Journal of Human Genetics · doi:10.1086/380999 · Cited by 706
Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1
Abe, T., Kakyo, M., Tokui, T., Nakagomi, R., Nishio, T., Nakai, D., Nomura, H., Unno, M., Suzuki, M., Naitoh, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17159 · Cited by 543
Molecular Basis of Thyroid Hormone-Dependent Brain Development
Oppenheimer, J. H., & Schwartz, H. L. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.4.0309 · Cited by 517
Global Protein Stability Profiling in Mammalian Cells
Yen, H.-C. S., Xu, Q., Chou, D. M., Zhao, Z., & Elledge, S. J. (2008) · Science · doi:10.1126/science.1160489 · Cited by 482
Öberg, C., Li, J., Pauley, A. M., Wolf, E., Gurney, M. E., & Lendahl, U. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103992200 · Cited by 412
Hennemann, G., Docter, R., Friesema, E. C. H., de Jong, M., Krenning, E. P., & Visser, T. J. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0435 · Cited by 394
Self-citationAllan-Herndon-Dudley Syndrome and the Monocarboxylate Transporter 8 (MCT8) Gene
Schwartz, C. E., May, M. M., Carpenter, N. J., Rogers, R. C., Martin, J. A., Bialer, M. G., Ward, J. C., Sanabria, J., Marsa, S., Lewis, J. A., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/431313 · Cited by 377
PRICE, T. N., JACKSON, N. V., & HALESTRAP, P. A. (1998) · Biochemical Journal · doi:10.1042/bj3290321 · Cited by 361
Translation Initiation at Non-Aug Triplets in Mammalian Cells
Peabody, D. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83694-8 · Cited by 357
Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8
Trajkovic, M., Visser, T. J., Mittag, J., Horn, S., Lukas, J., Darras, V. M., Raivich, G., Bauer, K., & Heuer, H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28253 · Cited by 353
Self-citationProteins Associated with the Thyroid Hormones
ROBBINS, J. J., & Rall, J. E. (1960) · Physiological Reviews · doi:10.1152/physrev.1960.40.3.415 · Cited by 349
Abe, T., Kakyo, M., Sakagami, H., Tokui, T., Nishio, T., Tanemoto, M., Nomura, H., Hébert, S., Matsuno, S., Kondo, H., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22395 · Cited by 334
Pizzagalli, F., Hagenbuch, B., Stieger, B., Klenk, U., Folkers, G., & Meier, P. J. (2002) · Molecular Endocrinology · doi:10.1210/me.2001-0309 · Cited by 326
Roberts, L. M., Woodford, K., Zhou, M., Black, D. S., Haggerty, J. E., Tate, E. H., Grindstaff, K. K., Mengesha, W., Raman, C., & Zerangue, N. (2008) · Endocrinology · doi:10.1210/en.2008-0378 · Cited by 320
Dumitrescu, A. M., Liao, X.-H., Weiss, R. E., Millen, K., & Refetoff, S. (2006) · Endocrinology · doi:10.1210/en.2006-0390 · Cited by 318
Defining the Roles of the Iodothyronine Deiodinases: Current Concepts and Challenges
Germain, D. L. S., Galton, V. A., & Hernández, A. (2009) · Endocrinology · doi:10.1210/en.2008-1588 · Cited by 303
Mikkaichi, T., Suzuki, T., Onogawa, T., Tanemoto, M., Mizutamari, H., Okada, M., Chaki, T., Masuda, S., Tokui, T., Eto, N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304987101 · Cited by 288
Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10
Friesema, E. C. H., Jansen, J., Jachtenberg, J.-W., Visser, W. E., Kester, M. H. A., & Visser, T. J. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0112 · Cited by 285
Self-citationSugiyama, D., Kusuhara, H., Taniguchi, H., Ishikawa, S., Nozaki, Y., Aburatani, H., & Sugiyama, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306933200 · Cited by 283
Heuer, H., Maier, M. K., Iden, S., Mittag, J., Friesema, E. C. H., Visser, T. J., & Bauer, K. (2005) · Endocrinology · doi:10.1210/en.2004-1179 · Cited by 269
Self-citationThyroid hormone transport in and out of cells
Visser, W. E., Friesema, E. C. H., Jansen, J., & Visser, T. J. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.11.003 · Cited by 236
Self-citationKim, D. K., Kanai, Y., Chairoungdua, A., Matsuo, H., Ho, S., & Endou, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009462200 · Cited by 235
Thyroid hormone action at the cellular, genomic and target gene levels
Yen, P. M., Ando, S., Feng, X., Liu, Y., Maruvada, P., & Xia, X. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.030 · Cited by 216
Friesema, E. C. H., Kuiper, G. G. J. M., Jansen, J., Visser, T. J., & Kester, M. H. A. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0256 · Cited by 214
Self-citationCamacho, J. A., Obie, C., Biery, B. J., Goodman, B. K., Hu, C.-A. A., Almashanu, S., Steel, G., Casey, R. E., Lambert, M. A., Mitchell, G. A., et al. (1999) · Nature Genetics · doi:10.1038/9658 · Cited by 207
Wirth, E. K., Roth, S., Blechschmidt, C., Hölter, S. M., Becker, L., Rácz, I., Zimmer, A., Klopstock, T., Gailus‐Durner, V., Fuchs, H., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6055-08.2009 · Cited by 196
Thyroid Hormone Effects on Mitochondrial Energetics
Harper, M.-E., & Seifert, E. L. (2008) · Thyroid · doi:10.1089/thy.2007.0250 · Cited by 194
Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters
Leuthold, S., Hagenbuch, B., Mohebbi, N., Wagner, C. A., Meier, P. J., & Stieger, B. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00436.2008 · Cited by 192
Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies
Nishimura, M., & Naito, S. (2008) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.23.22 · Cited by 190
Fujiwara, K., Adachi, H., Nishio, T., Unno, M., Tokui, T., Okabe, M., Onogawa, T., Suzuki, T., Asano, N., Tanemoto, M., et al. (2001) · Endocrinology · doi:10.1210/endo.142.5.8115 · Cited by 188
Thyroid Hormone Transport by the Heterodimeric Human System L Amino Acid Transporter
Friesema, E. C. H., Docter, R., Moerings, E. P. C. M., Verrey, F., Krenning, E. P., HENNEMANN, G., & Visser, T. J. (2001) · Endocrinology · doi:10.1210/endo.142.10.8418 · Cited by 187
Self-citationThyroid hormone transporters in health and disease
Jansen, J., Friesema, E. C. H., Milici, C., & Visser, T. J. (2005) · Thyroid · doi:10.1089/thy.2005.15.757 · Cited by 181
Self-citationIdentification of Thyroid Hormone Transporters
Friesema, E. C. H., Docter, R., Moerings, E. P. C. M., Stieger, B., Hagenbuch, B., Meier, P. J., Krenning, E. P., HENNEMANN, G., & Visser, T. J. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9974 · Cited by 177
Self-citationCeballos, A., Belinchon, M. M., Sanchez-Mendoza, E., Grijota-Martinez, C., Dumitrescu, A. M., Refetoff, S., Morte, B., & Bernal, J. (2009) · Endocrinology · doi:10.1210/en.2008-1616 · Cited by 173
Huber, R. D., Gao, B., Sidler, M.-A., Zhang-Fu, W., Leuthold, S., Hagenbuch, B., Folkers, G., Meier, P. J., & Stieger, B. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00597.2005 · Cited by 167
Tohyama, K., Kusuhara, H., & Sugiyama, Y. (2004) · Endocrinology · doi:10.1210/en.2004-0058 · Cited by 155
Nuclear Cytoplasmic Shuttling by Thyroid Hormone Receptors
Baumann, C. T., Maruvada, P., Hager, G. L., & Yen, P. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011112200 · Cited by 147
The MCT8 thyroid hormone transporter and Allan–Herndon–Dudley syndrome
Schwartz, C. E., & Stevenson, R. E. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.03.009 · Cited by 146
Neuroanatomical Pathways for Thyroid Hormone Feedback in the Human Hypothalamus
Alkemade, A., Friesema, E. C., Unmehopa, U. A., Fabriek, B. O., Kuiper, G. G., Leonard, J. L., Wiersinga, W. M., Swaab, D. F., Visser, T. J., & Fliers, E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2567 · Cited by 146
Self-citationCattori, V., Hagenbuch, B., Hagenbuch, N., Stieger, B., Ha, R., Winterhalter, K. H., & Meier, P. J. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01596-9 · Cited by 144
The role of nuclear pores in gene regulation, development and disease
Capelson, M., & Hetzer, M. W. (2009) · EMBO Reports · doi:10.1038/embor.2009.147 · Cited by 143
Lyck, R., Ruderisch, N., Moll, A. G., Steiner, O., Cohen, C. D., Engelhardt, B., Makrides, V., & Verrey, F. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.72 · Cited by 142
Kim, D. K., Kanai, Y., Matsuo, H., Kim, J. Y., Chairoungdua, A., Kobayashi, Y., Enomoto, A., Ho, S., Goya, T., & Endou, H. (2002) · Genomics · doi:10.1006/geno.2001.6678 · Cited by 136
Cellular entry of thyroid hormones by organic anion transporting polypeptides
Hagenbuch, B. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.03.004 · Cited by 135
van der Deure, W. M., Peeters, R. P., & Visser, T. J. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0042 · Cited by 130
Self-citationOppenheimer, J. H., & Schwartz, H. L. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111667 · Cited by 127
Genetics and phenomics of thyroid hormone transport by MCT8
Friesema, E. C. H., Visser, W. E., & Visser, T. J. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.016 · Cited by 115
Self-citationCosmo, C. D., Liao, X.-H., Dumitrescu, A. M., Weiss, R. E., & Refetoff, S. (2009) · Endocrinology · doi:10.1210/en.2009-0209 · Cited by 109
A novel transmembrane transporter encoded by the XPCT gene in Xq13.2
Lafrenière, R. G. A., Carrel, L., & Willard, H. F. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.7.1133 · Cited by 109
Pelizaeus–Merzbacher–Like disease presentation of MCT8 mutated male subjects
Vaurs‐Barrière, C., Deville, M., Sarret, C., Giraud, G., Portes, V. D., Jm, P.-V., Michele, G. D., Dan, B., Brady, A. F., Boespflug‐Tanguy, O., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21579 · Cited by 108
Wémeau, J.-L., Pigeyre, M., Proust-Lemoine, E., D’Herbomez, M., Gottrand, F., Jansen, J., Visser, T. J., & Ladsous, M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2719 · Cited by 105
Self-citationGenotype-Phenotype Relationship in Patients with Mutations in Thyroid Hormone Transporter MCT8
Jansen, J., Friesema, E. C. H., Kester, M. H. A., Schwartz, C. E., & Visser, T. J. (2008) · Endocrinology · doi:10.1210/en.2007-1475 · Cited by 99
Self-citationBasolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway
Ramadan, T., Camargo, S. M. R., Summa, V., Hunziker, P., Chesnov, S., Pos, K. M., & Verrey, F. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20531 · Cited by 97
Van Der Deure, W. M., Appelhof, B. C., Peeters, R. P., Wiersinga, W. M., Wekking, E. M., Huyser, J., Schene, A. H., Tijssen, J. G. P., Hoogendijk, W. J. G., Visser, T. J., et al. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03267.x · Cited by 97
Self-citationExpression of thyroid hormone transporters during critical illness
Mebis, L., Paletta, D., Debaveye, Y., Ellger, B., Langouche, L., D'Hoore, A., Darras, V. M., Visser, T. J., & Van den Berghe, G. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0290 · Cited by 97
Self-citationBiebermann, H., Ambrugger, P., Tarnow, P., von Moers, A., Schweizer, U., & Grueters, A. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01980 · Cited by 97
Chan, S.-Y., Franklyn, J. A., Pemberton, H. N., Bulmer, J. N., Visser, T. J., McCabe, C. J., & Kilby, M. D. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06582 · Cited by 97
Self-citationIdentification and Characterization of Novel Rat and Human Gonad-Specific Organic Anion Transporters
Suzuki, T., Onogawa, T., Asano, N., Mizutamari, H., Mikkaichi, T., Tanemoto, M., Abe, M., Satoh, F., Unno, M., Nunoki, K., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0304 · Cited by 93
X-Linked MCT8 Gene Mutations: Characterization of the Pediatric Neurologic Phenotype
Holden, K. R., Zuñiga, O. F., May, M. M., Su, H., Molinero, M. R., Rogers, R. C., & Schwartz, C. E. (2005) · Journal of Child Neurology · doi:10.1177/08830738050200101601 · Cited by 92
FUNCTIONAL CHARACTERIZATION OF HUMAN MONOCARBOXYLATE TRANSPORTER 6 (SLC16A5)
Murakami, Y., Kohyama, N., Kobayashi, Y., Ohbayashi, M., Ohtani, H., Sawada, Y., & Yamamoto, T. (2005) · Drug Metabolism and Disposition · doi:10.1124/dmd.105.005264 · Cited by 88
Thyroid hormone transport by monocarboxylate transporters
Visser, W. E., Friesema, E. C. H., Jansen, J., & Visser, T. J. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.03.008 · Cited by 88
Self-citationVié, M. P., Evrard, C., Osty, J., Breton-Gilet, A., Blanchet, P., Pomérance, M., Rouget, P., Francon, J., & Blondeau, J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.11.9915 · Cited by 87
Non-genomic actions of thyroid hormone in brain development
Leonard, J. (2007) · Steroids · doi:10.1016/j.steroids.2007.12.016 · Cited by 84
Jansen, J., Friesema, E. C. H., Kester, M. H. A., Milici, C., Reeser, M., Grüters, A., Barrett, T. G., Mancilla, E. E., Svensson, J., Wémeau, J.-L., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2570 · Cited by 78
Self-citationNovel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations
Visser, W. E., Jansen, J., Friesema, E. C. H., Kester, M. H. A., Mancilla, E., Lundgren, J., van der Knaap, M. S., Lunsing, R. J., Brouwer, O. F., & Visser, T. J. (2009) · Human Mutation · doi:10.1002/humu.20808 · Cited by 75
Self-citationFrints, S. G. M., Lenzner, S., Bauters, M., Jensen, L. R., Esch, H. V., Portes, V. D., Moog, U., Macville, M. V. E., van Roozendaal, K. E. P., Schrander-Stumpel, C. T. R. M., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.66 · Cited by 73
van der Deure, W. M., Hansen, P. S., Peeters, R. P., Kyvik, K. O., Friesema, E. C. H., Hegedűs, L. D., & Visser, T. J. (2008) · Endocrinology · doi:10.1210/en.2008-0430 · Cited by 69
Self-citationSurface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent
Kinne, A., Roth, S., Biebermann, H., Köhrle, J., Grüters, A., & Schweizer, U. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0043 · Cited by 67
The binding of thyroid hormones to phospholipid membranes
Hillier, A. P. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009295 · Cited by 66
Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary
Alkemade, A., Friesema, E. C. H., Kuiper, G. G. J. M., Wiersinga, W. M., Swaab, D. F., Visser, T. J., & Fliers, E. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02111 · Cited by 65
Self-citationTrajkovic‐Arsic, M., Visser, T. J., Darras, V., Friesema, E. C. H., Schlott, B., Mittag, J., Bauer, K., & Heuer, H. (2009) · Endocrinology · doi:10.1210/en.2009-1053 · Cited by 63
Self-citationZhou, Y., Samson, M., Francon, J., & Blondeau, J. (1992) · Biochemical Journal · doi:10.1042/bj2810081 · Cited by 62
Zhou, Y., Samson, M., Osty, J., Francon, J., & Blondeau, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44859-9 · Cited by 62
Study of the transport of thyroid hormone by transporters of the SLC10 family
Visser, W. E., Wong, W. S., van Mullem, A. A., Friesema, E. C. H., Geyer, J., & Visser, T. J. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.003 · Cited by 62
Self-citationμ-Crystallin as an Intracellular 3,5,3′-Triiodothyronine Holder in Vivo
Suzuki, S., Suzuki, N., Mori, J.-I., Oshima, A., Usami, S., & Hashizume, K. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0403 · Cited by 62
Thyroid hormone export from cells: contribution of P-glycoprotein
Mitchell, A. M., Tom, M., & Mortimer, R. H. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06096 · Cited by 49
Westholm, D. E., Salo, D. R., Viken, K. J., Rumbley, J. N., & Anderson, G. W. (2009) · Endocrinology · doi:10.1210/en.2009-0769 · Cited by 47
Thyroid Hormone Export Regulates Cellular Hormone Content and Response
Ribeiro, R. C. J., Cavalieri, R. R., Lomri, N., Rahmaoui, C. M., Baxter, J. D., & Scharschmidt, B. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17147 · Cited by 46
Capelo, L. P., Beber, E. H., Fonseca, T. L., & Gouveia, C. H. D. A. (2009) · Thyroid · doi:10.1089/thy.2008.0120 · Cited by 45
1H Magnetic Resonance Spectroscopy in Monocarboxylate Transporter 8 Gene Deficiency
Sijens, P. E., Rödiger, L. A., Meiners, L. C., & Lunsing, R. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2441 · Cited by 45
Blood—Brain Barrier Genomics and Cloning of a Novel Organic Anion Transporter
Chu, C., Li, J. Y., Boado, R. J., & Pardridge, W. M. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600538 · Cited by 42
Multispecific Substrate Recognition of Kidney-Specific Organic Anion Transporters OAT-K1 and OAT-K2
Takeuchi, A., Masuda, S., Saito, H., Abe, T., & Inui, K. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29326-5 · Cited by 42
Membrane proteomic analysis of human mesenchymal stromal cells during adipogenesis
Jeong, J. A., Ko, K., Park, H. S., Lee, J., Jang, C., Jeon, C., Koh, G. Y., & Kim, H. (2007) · PROTEOMICS · doi:10.1002/pmic.200700502 · Cited by 41
Silvestri, E., Lombardi, A., de Lange, P., Schiavo, L., Lanni, A., Goglia, F., Visser, T. J., & Moreno, M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00044.2008 · Cited by 39
Self-citationGenetic variation in thyroid hormone transporters
van der Deure, W. M., Peeters, R. P., & Visser, T. J. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.03.006 · Cited by 31
Self-citationEvidence for a Homodimeric Structure of Human Monocarboxylate Transporter 8
Visser, W. E., Philp, N. J., van Dijk, T. B., Klootwijk, W., Friesema, E. C. H., Jansen, J., Beesley, P. W., Ianculescu, A. G., & Visser, T. J. (2009) · Endocrinology · doi:10.1210/en.2009-0699 · Cited by 29
Self-citationThyroid Hormone Export Varies among Primary Cells and Appears to Differ from Hormone Uptake
Neves, F. D. A. R., Cavalieri, R. R., Simeoni, L. A., Gardner, D. G., Baxter, J. D., Scharschmidt, B. F., Lomri, N., & Ribeiro, R. C. J. (2002) · Endocrinology · doi:10.1210/endo.143.2.8631 · Cited by 21
Cavalieri, R. R., Simeoni, L. A., Park, S. W., Baxter, J. D., Scharschmidt, B. F., Ribeiro, R. C. J., & Lomri, N. (1999) · Endocrinology · doi:10.1210/endo.140.11.7127 · Cited by 21
Monocarboxylate Transporter 8 in Neuronal Cell Growth
James, S. R., Franklyn, J. A., Reaves, B. J., Smith, V. E., Chan, S., Barrett, T. G., Kilby, M. D., & McCabe, C. J. (2008) · Endocrinology · doi:10.1210/en.2008-1031 · Cited by 20
HENNEMANN, G., Vos, R. A., de Jong, M., Krenning, E. P., & Docter, R. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.5.8077346 · Cited by 20
Lago‐Lestón, R. M., Iglesias, M., San‐José, E., Areal, C., Eiras, A., Araújo‐Vilar, D., Lado‐Abeal, J., & Domínguez‐Gerpe, L. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03377.x · Cited by 17
Moreno, M., Silvestri, E., Lombardi, A., Visser, T. J., Goglia, F., & Lanni, A. (2003) · Endocrinology · doi:10.1210/en.2002-0174 · Cited by 12
Self-citationTryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells
Ritchie, J. W. A., & Taylor, P. M. (2009) · Amino Acids · doi:10.1007/s00726-009-0344-6 · Cited by 8
Transport of Thyroxine and 3,3′,5-Triiodothyronine in Human Umbilical Vein Endothelial Cells
Visser, W. E., Friesema, E. C. H., & Visser, T. J. (2008) · Endocrinology · doi:10.1210/en.2008-0627 · Cited by 6
Self-citationHeuer, H., Maier, M. E., Iden, S., Mittag, J., Friesema, E. C. H., Visser, T. J., & Bauer, K. (2004) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2004-832905 · Cited by 2
Self-citation
Research works printed but not linked: 7
- Dumitrescu, 2004, On the mechanism producing the unusual thyroid phenotype in defects of the MCT8 gene., Thyroid, 14, 761
- Trajkovic, 2007, The thyroid hormone transporter MCT8 is critically involved in the uptake of T3 into the mouse CNS., Thyroid, 17, 1171
- Deure, 2008, OATP1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism., Endocrinology, 149, 1495
- Kinne, 2009, Surface translocation and T3 uptake of mutant MCT8 proteins are cell type-dependent., J Mol Endocrinol, 43, 263, 10.1677/JME-09-0043 · DOI
- Trajkovic-Arsic, 2010, Consequences of MCT8 deficiency on renal and thyroidal transport of thyroid hormones., Endocrinology, 151, 802, 10.1210/en.2009-1053 · DOI
- Dumitrescu, 2007, High circulating T3 in Mct8 deficient mice is an age related postnatal event dependent on the ontogeny of deiodinases, Endocrinology (Abstract)
- Hameed, 2009, 3,5-Diiodothyropropionic acid (DITPA) in the treatment of patients with MCT8 deficiency: a preliminary study, Lawson Wilkins Pediatric Endocrine Society/European Society for Pediatric Endocrinology, New York, NY
Cited by
Sorted by citations
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
Thyroid Hormone Regulation of Metabolism
Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421
Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
“This diversity results from cells and tissues varying in terms of their expression of transmembrane transporters, deiodinases, nuclear TR subtypes, and coregulators (9,358,359).”
Mechanisms of thyroid hormone action
Brent, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60047 · Cited by 1,244
The SLC16 gene family – Structure, role and regulation in health and disease
Halestrap, A. P. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.05.003 · Cited by 768
Metadata
- Authors
- Visser, W. E., Friesema, E. C. H., & Visser, T. J.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Visser, Theo J.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2011-01-01
- Volume
- 25
- Issue
- 1
- Pages
- 1-14
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC5417302
- OpenAlex
- W1991454487
- Cited by
- 390
- References
- 101
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 11 · 2023: 13 · 2022: 17 · 2021: 20 · 2020: 23 · 2019: 34 · 2018: 22 · 2017: 40 · 2016: 37 · 2015: 34 · 2014: 40 · 2013: 32 · 2012: 23
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Endocrinology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Keywords
- thyroid hormone transporters, thyroid hormones, MCT8, MCT10, OATP1C1, monocarboxylate transporters, organic anion transporting polypeptides, psychomotor retardation, neurological abnormalities
- MeSH terms
- Animals, Humans, Mutation, Thyroid Hormones, Monocarboxylic Acid Transporters
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
