Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes

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  1. mtDNA Single-Nucleotide Variants Associated with Type 2 Diabetes
    Enrique García Gaona, Alhelí García-Gregorio, Camila García Jiménez, Mildred Alejandra López-Olaiz, Paola Mendoza-Ramírez, Daniel Fernandez‐Guzman, Rolando Alberto Pillado Sánchez, Axel David Soto Pacheco, Laura Yareni Zúñiga, María Guadalupe Sánchez Parada et al. · 2023 · Current Issues in Molecular Biology
  2. The transcriptomic and epigenetic alterations in type 2 diabetes mellitus patients of Chinese Tibetan and Han populations
    Xian Wang, Jie Liu, Qiuhong Wang, Qiu Chen · 2023 · Frontiers in Endocrinology
  3. Epigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
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  4. Obese mothers supplemented with melatonin during gestation and lactation ameliorate the male offspring’s pancreatic islet cellular composition and beta-cell function
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  5. Glucose metabolism partially regulates β‐cell function through epigenomic changes
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  6. Maternal Vitamin D Deficiency Impairs the Development of β Cells in Offspring Rats in a Sex-Dependent Manner
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  7. Rosa canina extract relieves methylation alterations of pancreatic genes in STZ-induced diabetic rats
    Hadis Javid, Soraya Sajadimajd, M Bahrami, Gholamreza Bahrami, Bahareh Mohammadi, Saeed Khazayel, Shahram Miraghaee · 2024 · Molecular Biology Reports
  8. Current approaches in CRISPR-Cas systems for diabetes
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  9. The impact of site-specific DNA methylation in KCNJ11 promoter on type 2 diabetes
    Mengmeng Zhu, Qiaoliang Huang, H. Li, Yujie Zhao, Heming Guo, Tao Wang, Xiaodan Liu, Yun Long Huang, Ji Hu, Chen Fang et al. · 2024 · Heliyon
  10. Natural selection and type 2 diabetes‐associated mortality in an isolated indigenous community in the valley of Oaxaca, southern Mexico
    Bertis B. Little, María Eugenia Peña Reyes, Robert M. Malina · 2016 · American Journal of Physical Anthropology
  11. Accelerated Generation of Extra-Islet Insulin-Producing Cells in Diabetic Rats, Treated with Sodium Phthalhydrazide
    Musa T. Abidov, Ksenia V. Sokolova, Ирина Федоровна Гетте, Irina Georgievna Danilova · 2022 · International Journal of Molecular Sciences
  12. Comparative splenic proteomic analysis of susceptible and resistant GIFT tilapia following challenge with Streptococcus agalactiae
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  13. Pharmacoepigenetics in type 2 diabetes: is it clinically relevant?
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  14. Lifestyle and NR3C1 exon 1F gene methylation is associated with changes in glucose levels and insulin resistance
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  15. Epigenetic regulation in type II diabetes: linking molecular mechanisms to clinical management
    Maryam Chaudhry, Saı̈d Sif · 2026 · Journal of Diabetes & Metabolic Disorders
  16. Impact of excess sugar on the whole genome DNA methylation pattern in human sperm
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  17. Alu Methylation Patterns in Type 1 Diabetes: A Case-Control Study
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  18. Applicability of Mesenchymal Stem Cell-Derived Exosomes as a Cell-Free miRNA Therapy and Epigenetic Modifiers for Diabetes
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  19. Nutritional Epigenetics and Aging
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  20. The epigenetic impact of lifestyle factors on metabolic syndrome: A systematic review
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  21. Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes
    Jones K. Ofori, Sabrina Ruhrmann, Axel Lindström, Alexander Perfilyev, Melina Martin, Alexandros Karagiannopoulos, Lucia Scisciola, Katja Kost, Josefine Jönsson, Åsa Nilsson et al. · 2026 · Nature Metabolism
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  26. Medicinal Effects of Agathosma (Buchu) Extracts
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  27. Blood DNA methylation and type 2 diabetes mellitus
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  28. Nutriepigenomics
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    Sarah Munns, Alex D. H. Brown, Sam Buckberry · 2025 · Frontiers in Molecular Biosciences
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  32. Precision Medicine and Epigenetics
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  34. Epigenetic and transcriptomic alterations in the ClC-3-deficient mice consuming a normal diet
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  35. Chromatin landscape and epigenetic biomarkers for clinical diagnosis and prognosis of type 2 diabetes mellitus
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  36. Epigenetic and Developmental Basis of Risk of Obesity and Metabolic Disease
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  37. Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion
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  38. Genome plasticity and endocrine diseases
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  40. The Impact of Epigenetics on the Pathophysiology of Type 2 Diabetes and Associated Nephropathic Complications
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  41. Is Predisposition to T2D Impacted by Polymorphisms in Genes Involved in Insulin Signaling and Cellular Bioenergetics?
    Benudhara Pati, Martin Jastroch, Naresh Chandra Bal · 2025 · Acta Physiologica
  42. The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
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  44. DNA methylation
    Liang Wang, Xingang Li, Daoquan Tang, Wei Wang · 2020 · Elsevier eBooks
  45. Type 1 diabetes mellitus in the context of high levels of rural deprivation: differences in demographic and anthropometric characteristics between urban and rural cases in NW Ethiopia
    Shitaye Alemu Balcha, David I. Phillips, Elisabeth R. Trimble · 2024 · Frontiers in Clinical Diabetes and Healthcare
  46. Nutriepigenomics: Paving the way for personalized nutrition
    Yoon Jung Park, Seung‐Min Song, Yerim Han, Anders M. Lindroth · 2024 · Elsevier eBooks
  47. DNA methylation in the association between pesticide exposures and type 2 diabetes
    Guang-Jun Zheng, Zheng-Er Fang, Bi-Ying Zhou, Lei Zuo, Xia Chen, Mingliang Liu, Lei Yu, Chunxia Jing, Guang Hao · 2024 · World Journal of Diabetes
  48. Targeting endothelial cell metabolism: new therapeutic prospects?
    Annalisa Zecchin, Aleksandra Brajic, Peter Carmeliet · 2015 · Frontiers in Biology
  49. The Impact of Exercise on DNA Methylation of Genes Associated with Type 2 Diabetes and Obesity in Human Adipose Tissue
    Tina Rönn, Charlotte Ling, Associate Researcher · 2014 · US Endocrinology
  50. Epigenetic Modifications and Type 2 Diabetes in Humans
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  51. Epigenetics of Diabetes in Humans
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  54. Epigenetics of diabetes in humans
    Renu A. Kowluru, Anjaneyulu Kowluru · 2023 · Elsevier eBooks
  55. Resistance Training Modulates the Humoral Inflammatory (but Not the DNA Methylation) Profile of Diabetic Older Adults Using Metformin
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  56. Metformin-Mg2+ adjunct therapy synergistically modulates insulin and PDX-1 gene signatures in STZ-NAD induced diabetic model
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  57. Epigenetic Epidemiology of Obesity and Type 2 Diabetes
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  58. Insulin- and glucagon-producing cells in the liver and biliary–pancreatic axis of rats with experimentally induced metabolic syndrome
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  59. Functions and Mechanisms of Diabetes-Linked Transcription Factors
    Naveen Kumar Parthiban, Najah Therese Nassif, Ann Margaret Simpson · 2025 · Frontiers in Bioscience-Landmark
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  63. Mechanisms of Programming: Pancreatic Islets and Fetal Programming
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