Identification of a Dynamic Mitochondrial Protein Complex Driving Cholesterol Import, Trafficking, and Metabolism to Steroid Hormones
Rone, Malena B., Midzak, Andrew S., Issop, Leeyah, Rammouz, Georges, Jagannathan, Sathvika, Fan, Jinjiang, Ye, Xiaoying, Blonder, Josip, Veenstra, Timothy, Papadopoulos, Vassilios·2012·Molecular Endocrinology
Cited by (248)
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- DEHP-mediated oxidative stress leads to impaired testosterone synthesis in Leydig cells through the cAMP/PKA/SF-1/StAR pathwayLuchen Yang, Shengzhuo Liu, Pan Song, Zhenghuan Liu, Zhufeng Peng, De-Pei Kong, Jing Zhou, Xin Yan, Kai Ma, Yunfei Yu et al. · 2024 · Environmental Pollution
- Friend or Foe? Mitochondria as a Pharmacological Target in Cancer TreatmentTyler Dickerson, Catherine E. Jauregui, Yong Teng · 2017 · Future Medicinal Chemistry
- Testosterone recovery therapy targeting dysfunctional Leydig cellsSamuel Garza, Vassilios Papadopoulos · 2022 · Andrology
- The ER-mitochondria Ca2+ signaling in cancer progression: Fueling the monsterGaldo Bustos, Ulises Ahumada-Castro, Eduardo Silva-Pavez, Andrea Puebla, Alenka Lovy, César Cárdenas · 2021 · International review of cytology
- Loss of mitochondrial ATPase ATAD3A contributes to nonalcoholic fatty liver disease through accumulation of lipids and damaged mitochondriaLiting Chen, Yuchang Li, Chantal M. Sottas, Anthoula Lazaris, Stephanie K. Petrillo, Peter P. Metrakos, Lu Li, Yuji Ishida, Takeshi Saito, Samuel Garza et al. · 2022 · Journal of Biological Chemistry
- Progesterone: Synthesis, Metabolism, Mechanism of Action, and Effects in the Nervous SystemMichaël Schumacher, Xiaoyan Zhu, Rachida Guennoun · 2016 · Elsevier eBooks
- Translocator protein and new targets for neuroinflammationMarisol Herrera-Rivero, Michael Thomas Heneka, Vassilios Papadopoulos · 2015 · Clinical and Translational Imaging
- BDE-47 Decreases Progesterone Levels in BeWo Cells by Interfering with Mitochondrial Functions and Genes Related to Cholesterol TransportAnqi Shan, Mengxue Li, Xuejun Li, Yaoyan Li, Mengfan Yan, Ping Xian, Ying Chang, Xi Chen, Naijun Tang · 2019 · Chemical Research in Toxicology
- In vivo blockade of 1-adrenergic receptors mitigates stress-disturbed cAMP and cGMP signaling in Leydig cellsN. J. Stojkov, Aleksandar Z. Baburski, Maja M. Bjelic, Srdjan J. Sokanovic, Aleksandar I. Mihajlović, Dragana M. Drljaca, Marija M. Janjic, Tatjana S. Kostic, Silvana A. Andrić · 2013 · Molecular Human Reproduction
- ATAD3A on the Path to CancerYong Teng, Liwei Lang, Chloe Shay · 2019 · Advances in experimental medicine and biology
- Evolving understanding of translocator protein 18kDa (TSPO)Fei Li, Jian Liu, R. Michael Garavito, Shelagh M. Ferguson-Miller · 2015 · Pharmacological Research
- Echinacoside Increases Sperm Quantity in Rats by Targeting the Hypothalamic Androgen ReceptorZhihui Jiang, Bo Zhou, Xinping Li, Gordon M. Kirby, Xiaoying Zhang · 2018 · Scientific Reports
- Mitochondria are midfield players in steroid synthesisPhilipp Melchinger, Bruna Martins Garcia · 2023 · The International Journal of Biochemistry & Cell Biology
- Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responsesAnnette Graham · 2015 · World Journal of Cardiology
- Μitochondrial Membrane Dynamics and Inherited Optic NeuropathiesEleni Bagli, Anastasia K. Zikou, Niki John Agnantis, Georgios Kitsos · 2017 · In Vivo
- TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human bloodIrene Marginedas-Freixa, Claude Hattab, Guillaume Bouyer, François Hallé, Arnaud Chêne, Sophie Denise Lefevre, Marie Cambot, Anne Cueff, Martine Schmitt, Benoît Gamain et al. · 2016 · Scientific Reports
- Downregulation of Mitochondrial TSPO Inhibits Mitophagy and Reduces Enucleation During Human Terminal ErythropoiesisMartina Moras, Claude Hattab, Pedro González‐Menéndez, Suella Martino, Jérôme Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi N. Taylor, Sophie Denise Lefevre, Mariano A. Ostuni · 2020 · International Journal of Molecular Sciences
- Leydig cell aging: Molecular mechanisms and treatmentsVassilios Papadopoulos, B. R. Zirkin · 2021 · Vitamins and hormones
- Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cellsYiqi Christina Lin, Garett Cheung, Zeyu Zhang, Vassilios Papadopoulos · 2023 · Journal of Biological Chemistry
- Acute effects of hexabromocyclododecane on Leydig cell cyclic nucleotide signaling and steroidogenesis in vitroSvetlana Fa, Kristina Pogrmic‐Majkic, Vanja Dakić, Sonja Kaišarević, Jelena Hrubik, Nebojsa L. Andric, Stanko S. Stojilković, R. Kovačević · 2013 · Toxicology Letters
- Protein Modifications Regulate the Role of 14-3-3γ Adaptor Protein in cAMP-induced Steroidogenesis in MA-10 Leydig CellsYasaman Aghazadeh, Xiaoying Ye, Josip Blonder, Vassilios Papadopoulos · 2014 · Journal of Biological Chemistry
- Regulation of StAR by the N-terminal Domain and Coinduction of SIK1 and TIS11b/Znf36l1 in Single CellsJinwoo Lee, Tiegang Tong, Haichuan Duan, Yee Hoon Foong, Ibrahim Musaitif, Takeshi Yamazaki, Colin R. E. Jefcoate · 2016 · Frontiers in Endocrinology
- Increased steroidogenesis promotes early-onset and severe vision loss in females withOPA1dominant optic atrophyEmmanuelle Sarzi, Marie Seveno, Claire Angebault, Dan Miléa, Cecilia Rönnbäck, Mélanie Quilès, Mathias Adrian, Joanna Grenier, Angélique Caignard, Annie Lacroux et al. · 2016 · Human Molecular Genetics
- In Vivo Receptor Visualization and Evaluation of Receptor Occupancy with Positron Emission TomographyYuta Takamura, Hiroki Kakuta · 2021 · Journal of Medicinal Chemistry
- The heat shock protein 60 promotes progesterone synthesis in mitochondria of JEG-3 cellsJessica Monreal‐Flores, María Teresa Espinosa-García, Alejandro García-Regalado, Fabián Arechavaleta-Velasco, Federico Martı́nez · 2017 · Reproductive Biology
- Amhr2-Cre–Mediated Global Tspo KnockoutJinjiang Fan, Enrico Campioli, Chantal M. Sottas, Barry R. Zirkin, Vassilios Papadopoulos · 2020 · Journal of the Endocrine Society
- Insulin/IGF1 signaling regulates the mitochondrial biogenesis markers in steroidogenic cells of prepubertal testis, but not ovary†Sava M. Radovic Pletikosic, Isidora M. Starovlah, Ivan Čapo, Dejan Miljković, Serge Nef, Tatjana S. Kostic, Silvana A. Andrić · 2018 · Biology of Reproduction
- Computational modeling and biological validation of novel non-steroidal ligands for the cholesterol recognition/interaction amino acid consensus (CRAC) motif of the mitochondrial translocator protein (TSPO)Midzak, Andrew S., Akula, Nagaraju, Rone, Malena B., Papadopoulos, Vassilios · 2015 · Pharmacological Research
- Prognostic value of ATAD3 gene cluster expression in hepatocellular carcinomaXiaoling Liu, Gang Li, Liang Ai, Qiuwen Ye, Tingdong Yu, Burong Yang · 2019 · Oncology Letters
- Proteomic profile of the effects of low-dose bisphenol A on zebrafish ovariesAna María Molina-López, Nieves Abril, Antonio Jesús Lora-Benítez, Paula V. Huertas-Abril, Nahúm Ayala-Soldado, Carmen Blanco, Rosario Moyano · 2021 · Food and Chemical Toxicology
- Alternative pathways for vitamin D metabolismAndrzej T. Slominski, Robert Charles Tuckey, Carl Jenkinson, Wěi Li, Anton M. Jetten · 2023 · Elsevier eBooks
- Sustained in vivo blockade of α1-adrenergic receptors prevented some of stress-triggered effects on steroidogenic machinery in Leydig cellsNatasa J. Stojkov, Marija M. Janjic, Aleksandar Z. Baburski, Aleksandar I. Mihajlović, Dragana M. Drljaca, Srdjan J. Sokanovic, Maja M. Bjelic, Tatjana S. Kostic, Silvana A. Andrić · 2013 · American Journal of Physiology-Endocrinology and Metabolism
- Proteomics Recapitulates Ovarian Proteins Relevant to Puberty and Fertility in Brahman Heifers (Bos indicus L.)Muhammad S. Tahir, Loan T Nguyen, Benjamin Luke Schulz, Gry Brandt Boe-Hansen, Milton Thomas, S. S. Moore, Li Yieng Lau, Marina R. S. Fortes · 2019 · Genes
- Exploring mitochondrial cholesterol signalling for therapeutic intervention in neurological conditionsRadha Desai, Michelangelo Campanella · 2019 · British Journal of Pharmacology
- TSPO ligand FGIN‐1‐27 controls priapism in sickle cell mice via endogenous testosterone productionBiljana Musicki, Serkan Karakus, Justin D. La Favor, Haolin Chen, Fábio Henrique Silva, M. Sturny, Barry R. Zirkin, Arthur L. “Bud” Burnett · 2020 · Journal of Cellular Physiology
- Dynamic Remodeling of Membranes and Their Lipids during Acute Hormone-Induced Steroidogenesis in MA-10 Mouse Leydig Tumor CellsSathvika Venugopal, Melanie Galano, Rachel Chan, Esha Sanyal, Leeyah Issop, Sunghoon Lee, Lorne Taylor, Pushwinder Kaur, Edward Daly, Vassilios Papadopoulos · 2021 · International Journal of Molecular Sciences
- Regulation of adrenocortical steroid hormone production by RhoA–diaphanous 1 signaling and the cytoskeletonMarion B. Sewer, Donghui Li · 2012 · Molecular and Cellular Endocrinology
- Cholesterol accumulation, lipid droplet formation, and steroid production in Leydig cells: Role of translocator protein (18‐kDa)Jin‐Yong Chung, Haolin Chen, Vassilios Papadopoulos, Barry R. Zirkin · 2019 · Andrology
- Revisiting trends on mitochondrial mega-channels for the import of proteins and nucleic acidsMaría Luisa Campo, Pablo Marco Veras Peixoto, Sonia Martinez‐Caballero · 2016 · Journal of Bioenergetics and Biomembranes
- The Role of PBR/TSPO in Steroid Biosynthesis ChallengedDouglas M. Stocco · 2013 · Endocrinology
- Allopregnanolone: Metabolism, Mechanisms of Action, and Its Role in CancerCarmen J. Zamora-Sánchez, Ignacio Camacho‐Arroyo · 2022 · International Journal of Molecular Sciences
- Unraveling the complex interplay between Mitochondria-Associated Membranes (MAMs) and cardiovascular Inflammation: Molecular mechanisms and therapeutic implicationsXing Chen, Yang Yang, Zheng Zhou, Haihan Yu, Shuwei Zhang, Siyuan Huang, Ziqing Wei, Kaidi Ren, Yage Jin · 2024 · International Immunopharmacology
- Expression of steroidogenesis-related genes in murine male germ cellsMartine Culty, Ying Liu, Gurpreet Manku, Wai‐Yee Chan, Vassilios Papadopoulos · 2015 · Steroids
- Regulation of Leydig cell steroidogenesis: intriguing network of signaling pathways and mitochondrial signalosomeSilvana A. Andrić, Tatjana S. Kostic · 2019 · Current Opinion in Endocrine and Metabolic Research
- Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on PseudomonasCharlène Leneveu‐Jenvrin, Nathalie Connil, Emeline Bouffartigues, Vassilios Papadopoulos, Marc G. J. Feuilloley, Sylvie Chevalier · 2014 · Frontiers in Microbiology
- Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone SynthesisMelissa Witzig, Amandine Grimm, Karen Schmitt, Imane Lejri, Stephan Frank, Steven A. Brown, Anne Eckert · 2020 · Cells
- Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factorsSnehal Bindra, Marlon A. McGill, Marina K Triplett, Anisha Tyagi, Premal H. Thaker, Laila Dahmoush, Michael Joseph Goodheart, Robert Todd Ogden, Edward Owusu-Ansah, Kalpita R. Karan et al. · 2021 · Scientific Reports
- Steroidogenesis in MA-10 Mouse Leydig Cells Is Altered via Fatty Acid Import into the Mitochondria1Malena B. Rone, Andrew S. Midzak, Daniel Benjamin Martinez-Arguelles, Jinjiang Fan, Xiaoying Ye, Josip Blonder, Vassilios Papadopoulos · 2014 · Biology of Reproduction
- Leydig Cell Androgen SynthesisLu Li, Barry R. Zirkin, Vassilios Papadopoulos · 2017 · Elsevier eBooks
- The Ligands of Translocator Protein: Design and Biological PropertiesГригорий Владимирович Мокров, Ольга Алексеевна Деева, Татьяна Александровна Гудашева · 2020 · Current Pharmaceutical Design
- Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearanceBeibei Wu, Yuqing Liu, Hongli Li, Lemei Zhu, Lingfeng Zeng, Zhen Zhang, Weijun Peng · 2023 · Neural Regeneration Research
- Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43Tamara Azarashvili, Yulia L. Baburina, Dmitry Grachev, Olga V. Krestinina, Vassilios Papadopoulos, John J. Lemasters, Irina V Odinokova, Georg Reiser · 2014 · Archives of Biochemistry and Biophysics
- Angiotensin II stimulation promotes mitochondrial fusion as a novel mechanism involved in protein kinase compartmentalization and cholesterol transport in human adrenocortical cellsKatia E. Helfenberger, Ana Fernanda Castillo, Pablo G. Mele, Ana Fiore, Lucía M. Herrera, Paola Vanesa Finocchietto, Ernesto Jorge Podesta, Cecilia Poderoso · 2019 · The Journal of Steroid Biochemistry and Molecular Biology
- The Steroidogenic Acute Regulatory (STAR) Gene Anatomy, Expression, and RolesJ Lim, Yong‐Pil Cheon · 2025 · Development & Reproduction
- Construction and validation of an atomic model for bacterial TSPO from electron microscopy density, evolutionary constraints, and biochemical and biophysical dataKonrad Hinsen, Aurore Vaïtinadapoulé, Mariano A. Ostuni, Catherine Etchebest, Jean-Jacques Lacapère · 2014 · Biochimica et Biophysica Acta (BBA) - Biomembranes
- Annexins Bridging the Gap: Novel Roles in Membrane Contact Site FormationCarlos Enrich, Albert Lu, Francesc Tebar, Carles Rentero, Thomas Grewal · 2022 · Frontiers in Cell and Developmental Biology
- The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal ConditionsPhilippe Lière, Guo Jun Liu, Antoine Pianos, Ryan J. Middleton, Richard B. Banati, Yvette Akwa · 2023 · International Journal of Molecular Sciences
- 4'-Chlorodiazepam is neuroprotective against amyloid-beta through the modulation of survivin and bax protein expression in vitro.B. D. Arbo, C. V. Marques, I. Ruiz-Palmero, A. Ortiz-Rodriguez, S. Ghorbanpoor, M. Arevalo, L. Garcia-Segura, M. Ribeiro · 2016 · Brain Research
- Metabolomics approach to study in vivo toxicity of graphene oxide nanosheetsLeila Ghiasvand Mohammadkhani, Maryam Khoshkam, Mohsen Kompany‐Zareh, Mahdi Amiri, Ali Ramazani · 2021 · Journal of Applied Toxicology
- Structural Studies of TSPO, a Mitochondrial Membrane ProteinJean-Jacques Lacapère, Soria Iatmanen-Harbi, Lucile Sénicourt, Olivier Lequin, Piotr Tékély, Rudra N. Purusottam, Petra Hellwig, Sébastien Kriegel, Stéphanie Ravaud, Céline Juillan‐Binard et al. · 2014 · Springer eBooks
- Molecular adaptations of testosterone-producing Leydig cells during systemic in vivo blockade of the androgen receptorMaja M. Bjelic, Natasa J. Stojkov, Aleksandar Z. Baburski, Srdjan J. Sokanovic, Aleksandar I. Mihajlović, Marija M. Janjic, Tatjana S. Kostic, Silvana A. Andrić · 2014 · Molecular and Cellular Endocrinology
- Astrocyte Neuroprotection and DehydroepiandrosteroneBruno Dutra Arbo, Felipe S. Ribeiro, Maria Flávia Marques Ribeiro · 2018 · Vitamins and hormones
- Mitochondria form contact sites with the nucleus to couple pro-survival retrograde responseRadha Desai, Daniel A. East, Liana Hardy, Danilo Faccenda, Manuel Rigon, James Crosby, María Soledad Álvarez, Aarti Singh, Marta Mainenti, Laura Kuhlman Hussey et al. · 2020 · UCL Discovery (University College London)
- The Association of Mitochondrial Translocator Protein and Voltage-Dependent Anion Channel-1 in Granulosa Cells with Estradiol Levels and Presence of Immature Follicles in Polycystic Ovary SyndromeSahar Mazloomi, Marzieh Sanoee Farimani, Heidar Tayebinia, Jamshid Karimi, Iraj Amiri, Ebrahim Abbasi, Iraj Khodadadi · 2022 · Journal of Reproduction & Infertility
- Prolonged in vivo administration of testosterone-enanthate, the widely used and abused anabolic androgenic steroid, disturbs prolactin and cAMP signaling in Leydig cells of adult ratsMaja M. Bjelic, Natasa J. Stojkov, Sava M. Radovic Pletikosic, Aleksandar Z. Baburski, Marija M. Janjic, Tatjana S. Kostic, Silvana A. Andrić · 2015 · The Journal of Steroid Biochemistry and Molecular Biology
- Translocator Protein (TSPO) Expression in Platelets of Depressed Patients Decreases during Antidepressant TherapyNina Sarubin, Thomas C. Baghai, Juan M. Lima‐Ojeda, Doris Melchner, H. Hallof-Buestrich, L. Wolf, Sven Hilbert, Vladimir M. Milenkovic, Christian H. Wetzel, Rainer Rupprecht et al. · 2016 · Pharmacopsychiatry
- Development of new treatments for Alzheimer’s disease based on the modulation of translocator protein (TSPO)Bruno Dutra Arbo, Maria Flávia Marques Ribeiro, Luis Miguel García‐Segura · 2019 · Ageing Research Reviews
- Mitochondrial TSPO Deficiency Triggers Retrograde Signaling in MA-10 Mouse Tumor Leydig CellsJinjiang Fan, Vassilios Papadopoulos · 2020 · International Journal of Molecular Sciences
- A single cell level measurement of StAR expression and activity in adrenal cellsJinwoo Lee, Takeshi Yamazaki, Hui Dong, Colin R. E. Jefcoate · 2016 · Molecular and Cellular Endocrinology
- Refining a steroidogenic model: an analysis of RNA-seq datasets from insect prothoracic glandsPanagiotis Moulos, Αλέξανδρος Αλεξανδράτος, Ioannis Nellas, Skarlatos Dedos · 2018 · BMC Genomics
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- Copper overload worsens the inflammatory response of microglia to amyloid beta (Aβ) by impairing phagocytosis and promoting mitochondrial DNA-mediated NLRP3 inflammasome activationMarlene Zubillaga, Xenia Abadin, Elia Ivars, Margalida Puigròs, Ramón Trullás, María José Bellini, Nathalie Arnal, Anna Colell · 2025 · Redox Biology
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- PCSK9 Regulates Cardiac Mitochondrial Cholesterol by Promoting TSPO DegradationMarion Laudette, Malin Lindbom, Mathieu Cinato, Per‐Olof Bergh, Kristina Skålén, Muhammad Arif, Azra Miljanovic, Tomasz Czuba, Rosie Perkins, J. Gustav Smith et al. · 2025 · Circulation Research
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- Ketogenic diet attenuates cerebellar atrophy progression in a subject with a biallelic variant at the ATAD3A locusAshraf Said Al Madhoun, Fahad Alnaser, Motasem Melhem, Rasheeba Nizam, Tala Al-dabbous, Fahd Al‐Mulla · 2019 · The Application of Clinical Genetics
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- Characterization of Two Novel Variants of the Steroidogenic Acute Regulatory Protein Identified in a Girl with Classic Lipoid Congenital Adrenal HyperplasiaEfstathios Katharopoulos, Natascia Di Iorgi, Paula Fernández‐Álvarez, Amit V. Pandey, Michael Groessl, Shraddha Dubey, Núria Camats, Flavia Napoli, Giuseppa Patti, Marilea Lezzi et al. · 2020 · International Journal of Molecular Sciences
- Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO LigandsIrene Marginedas-Freixa, Cora Lilia Alvarez, Martina Moras, Claude Hattab, Guillaume Bouyer, Arnaud Chêne, Sophie Denise Lefevre, Caroline Le Van Kim, Frederic J.‐J. Bihel, Pablo Julio Schwarzbaum et al. · 2018 · International Journal of Molecular Sciences
- Cisatracurium stimulates testosterone synthesis in rat and mouse Leydig cells via nicotinic acetylcholine receptorChaobo Ni, Yang Li, Zengqiang Li, Lili Tian, Jie Fu, Ke-Yang Wu, Yi-Yan Wang, M. Yao, R. Ge · 2020 · Journal of Cellular and Molecular Medicine
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