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Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone
Open accessAbstract
A novel cDNA was isolated from rat pituitary mRNA using the polymerase chain reaction to amplify sequences encoding G protein-coupled receptors. The human homolog of this cDNA was isolated and expressed in human kidney 293 cells, and membrane fractions from these cells were found to bind human GH-releasing hormone (GHRH) with high affinity and specificity. GHRH also stimulates intracellular cAMP production in these transfected cells. The encoded receptor protein contains seven potential membrane-spanning domains, a hallmark of G protein-coupled receptors, and is homologous to previously identified receptors for secretin and vasoactive intestinal peptide, ligands that are related to GHRH. The rat GHRH receptor mRNA is expressed predominantly, if not exclusively, in the anterior pituitary gland, the major target for GHRH action. These results define a mechanism for cellular signaling by GHRH and provide the opportunity to examine the role of the GHRH receptor in growth abnormalities that involve the GH axis.
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Cited by
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Kojima, M., & Kangawa, K. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2004 · Cited by 2,810
Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253
Expression cloning of a human corticotropin-releasing-factor receptor.
Chen, R., Lewis, K. A., Perrin, M. H., & Vale, W. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8967 · Cited by 927
Opposing LSD1 complexes function in developmental gene activation and repression programmes
Wang, J., Scully, K., Zhu, X., Cai, L., Zhang, J., Prefontaine, G. G., Krones, A., Ohgi, K. A., Zhu, P., Garcia-Bassets, I., et al. (2007) · Nature · doi:10.1038/nature05671 · Cited by 579
Chang, C.-P., Pearse, R. V., O'Connell, S., & Rosenfeld, M. G. (1993) · Neuron · doi:10.1016/0896-6273(93)90230-o · Cited by 537
Metadata
- Authors
- Mayo, K. E.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1992-10-01
- Volume
- 6
- Issue
- 10
- Pages
- 1734-1744
- ISSN
- 0888-8809 (ISSN-L)
- OpenAlex
- W2045543114
- Cited by
- 365
- References
- 0
- FWCI
- 17.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mayo, K. E. (1992). Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone. Molecular Endocrinology. https://doi.org/10.1210/me.6.10.1734
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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