The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Expression cloning of a human corticotropin-releasing-factor receptor.
Open accessAbstract
Corticotropin-releasing factor (CRF) is the principal neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. We report here the cloning of a cDNA coding for a CRF receptor from a human corticotropic tumor library. The cloned cDNA encodes a 415-amino acid protein comprising seven putative membrane-spanning domains and is structurally related to the calcitonin/vasoactive intestinal peptide/growth hormone-releasing hormone subfamily of G protein-coupled receptors. The receptor expressed in COS cells binds rat/human CRF with high affinity (Kd = 3.3 +/- 0.45 nM) and specificity and is functionally coupled to adenylate cyclase. The CRF antagonist alpha-helCRF-(9-41) inhibits the CRF-stimulated increase in intracellular cAMP. Northern blot analysis reveals that the CRF receptor is expressed in the rat pituitary and brain as well as in the mouse AtT20 corticotropic cells. We also describe an alternatively spliced form of the receptor which includes an insert of 29 amino acids in the first intracellular loop.
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Cites
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504
Self-citationCorticotropin–releasing factor receptors in human pituitary gland: autoradiographic localization
De Souza, E. B., Perrin, M. H., Whitehouse, P. J., Rivier, J., Vale, W., & Kuhar, M. J. (2008) · Neuroendocrinology · doi:10.1159/000124107 · Cited by 66
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Cited by
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948
Self-citationCRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270
Self-citationLewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121165198 · Cited by 925
Self-citationNeuroendocrine pharmacology of stress
Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914
Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776
Metadata
- Authors
- Chen, R., Lewis, K. A., Perrin, M. H., & Vale, W. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-10
- Volume
- 90
- Issue
- 19
- Pages
- 8967-8971
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068818952
- Cited by
- 927
- References
- 2
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
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