The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Heparin-binding keratinocyte growth factor is a candidate stromal-to- epithelial-cell andromedin
Open accessAbstract
The growth of isolated epithelial and stromal cells from both androgen-dependent normal rat prostate and an androgen-responsive model rat prostate tumor is androgen-independent. When added to co-cultures of epithelial and stromal cells separated by a semipermeable membrane, androgen stimulated epithelial cell growth without an effect on stromal cell growth. Northern blot and nuclease protection analysis of mRNA revealed that stromal cells specifically expressed an androgen-sensitive secreted member of the heparin-binding fibroblast growth factor family [keratinocyte growth factor (KGF)/fibroblast growth factor-7]. KGF was mitogenic for epithelial cells, but not for stromal cells. Epithelial cells expressed specifically a splice variant of the bek receptor gene that specifically binds KGF. Expression of the bek receptor gene in stromal cells was undetectable by Northern blot and nuclease protection analyses. The results suggest that stromal cell-derived KGF has the properties of an andromedin, which mediates the indirect control of epithelial cell proliferation by androgen through a directional stromal-to-epithelial cell paracrine mechanism.
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Metadata
- Authors
- Yan, G.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1992-12-01
- Volume
- 6
- Issue
- 12
- Pages
- 2123-2128
- ISSN
- 0888-8809 (ISSN-L)
- OpenAlex
- W2079297033
- Cited by
- 294
- References
- 11
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yan, G. (1992). Heparin-binding keratinocyte growth factor is a candidate stromal-to- epithelial-cell andromedin. Molecular Endocrinology. https://doi.org/10.1210/me.6.12.2123
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
