The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Complementary Deoxyribonucleic Acid Cloning of a Messenger Ribonucleic Acid Encoding Transforming Growth Factor β 4 from Chicken Embryo Chondrocytes
Open accessAbstract
Using a human transforming growth factor beta 1 (TGF beta) cDNA probe, we have detected an RNA species migrating at about 1.7 kilobases in cultured primary chicken embryo chondrocytes that is distinct from chicken TGF beta 1. The cloning and sequencing of cDNAs corresponding to this chondrocyte RNA demonstrate that it represents a new member of the TGF beta family, which we have named TGF beta 4. Unlike previously described TGF beta which are 390 to 414 amino acids long, the predicted precursor protein of TGF beta 4 is only 304 amino acids and does not appear to contain a signal peptide. Also unique to this new TGF beta is an insertion of two amino acids near the N-terminus of the processed peptide which would result in a 114 amino acid mature protein after cleavage from the precursor at a tetrabasic arg-arg-arg-arg site. The nine cysteine residues characteristic of all TGF beta are conserved. TGF beta 4 shows 82%, 64%, and 71% identity with the amino acid sequences of processed TGF beta 1, 2, and 3, respectively.
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Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cited by
Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation.
Laiho, M., DeCaprio, J. A., Ludlow, J. W., Livingston, D. M., & Massague, J. (1990) · Cell · doi:10.1016/0092-8674(90)90251-9 · Cited by 797
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1990) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-49295-2_8 · Cited by 746
Self-citationIdentification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
Smith, J. C., Price, B. M. J., Nimmen, K. V., & Huylebroeck, D. (1990) · Nature · doi:10.1038/345729a0 · Cited by 657
Millan, F. A., Denhez, F., Kondaiah, P., & Akhurst, R. J. (1991) · Development · doi:10.1242/dev.111.1.131 · Cited by 498
Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily
Daopin, S., Piez, K. A., Ogawa, Y., & Davies, D. R. (1992) · Science · doi:10.1126/science.1631557 · Cited by 440
Metadata
- Authors
- Jakowlew, S. B., Dillard, P. J., Sporn, M. B., & Roberts, A. B.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1988-12
- Volume
- 2
- Issue
- 12
- Pages
- 1186-1195
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2102982923
- Cited by
- 221
- References
- 1
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jakowlew, S. B., Dillard, P. J., Sporn, M. B., & Roberts, A. B. (1988). Complementary Deoxyribonucleic Acid Cloning of a Messenger Ribonucleic Acid Encoding Transforming Growth Factor β 4 from Chicken Embryo Chondrocytes. Molecular Endocrinology. https://doi.org/10.1210/mend-2-12-1186
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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