The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Embryonic gene expression patterns of TGF β 1, β 2 and β 3 suggest different developmental functions in vivo
Abstract
We have compared the expression of the genes encoding transforming growth factors β1, β2 and β3 during mouse embryogenesis from 9.5 to 16.5 days p.c. using in situ hybridisation to cellular RNAs. Each gene has a different expression pattern, which gives some indication of possible biological function in vivo. All three genes appear to be involved in chondro ossification, though each is expressed in a different cell type. Transcripts of each gene are also present in embryonic epithelia. Epithelial expression of TGF β1, β2 and β3 RNA is associated with regions of active morphogenesis involving epithelial-mesenchymal inter actions. In addition, widespread epithelial expression of TGF β2 RNA can be correlated with epithelial differentiation per se. The localisation of TGF β2 RNA in neuronal tissue might also be correlated with differentiation. Finally both TGF β1 and β2 transcripts are seen in regions actively undergoing cardiac septation and valve formation, suggesting some interaction of these growth factors in this developmental process.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
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Cited by
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Making sense of latent TGFβ activation
Annes, J. P., Munger, J. S., & Rifkin, D. B. (2003) · Journal of Cell Science · doi:10.1242/jcs.00229 · Cited by 1,628
Targeting the TGFβ signalling pathway in disease
Akhurst, R. J., & Hata, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3810 · Cited by 1,466
Self-citationSanford, L. P., Ormsby, I., Groot, A. C. G.-D., Sariola, H., Friedman, R., Boivin, G. P., Cardell, E. L., & Doetschman, T. (1997) · Development · doi:10.1242/dev.124.13.2659 · Cited by 1,447
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401
Metadata
- Authors
- Millan, F. A., Denhez, F., Kondaiah, P., & Akhurst, R. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1991-01-01
- Volume
- 111
- Issue
- 1
- Pages
- 131-143
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2114154263
- Cited by
- 498
- References
- 43
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Embryonic gene expression patterns of TGF β 1, β 2 and β 3 suggest different developmental functions in vivo. https://app.cochat.ai/papers/10.1242/dev.111.1.131
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- Millan, F. A., Denhez, F., Kondaiah, P., & Akhurst, R. J. (1991). Embryonic gene expression patterns of TGF β 1, β 2 and β 3 suggest different developmental functions in vivo. Development. https://doi.org/10.1242/dev.111.1.131
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
